Preclinical evaluation of 99m Tc-labeled LHRH as GnRH receptor imaging
Lucía Alfaya,
Ximena Camacho,
Mirel Cabrera
et al.
Abstract:Breast cancer stands as the principal cause of cancer-related mortality among women in the developed world. Notably, receptors of Luteinizing Hormone-Releasing Hormone (LHRH or GnRH) exhibit overexpression in this malignancy. This study aimed to develop a new molecular prove [99mTc] Tc-HYNIC-GSG-LHRH(D-Lys6)/Tricine/Nicotinic Acid (NA) as a novel molecular imaging agent for breast cancer. HYNIC-GSG-LHRH(D-Lys6) was acquired and radiolabeled with [99mTc] Tc. The radiochemical purity and stability in different c… Show more
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