Precise Personalized Medicine in Gynecology Cancer and Infertility

Zhang, Pu-Yao; Yang, Yuanzheng

doi:10.3389/fcell.2019.00382

Cited by 19 publications

(15 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Initially, personalized medicine (PM) was dedicated to oncological patients and focused on knowledge of genes, proteins, and the environment in diagnostics, prophylaxis, prognosis, treatment, and categorization of patients [ 8 ]. This approach gave surprisingly good results in optimizing the therapy in oncology, hence the attempts to use PM in other fields of medicine, including dermatology, endocrinology, cardiology, orthopedics, psychiatry, or in reproductive medicine [ 2 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. The implementation of this idea in reproductive medicine offers considerable opportunities, as individual treatment of a specific person or a couple going beyond traditional clinical practice can significantly improve the effectiveness of the treatment [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Need of Personalized Medicine in Coping with Stress during Infertility Treatment

Nagórska

Obrzut

Ulman³

et al. 2021

JPM

View full text Add to dashboard Cite

The term personalized medicine was created for oncological patients, but due to its positive clinical results it is now used in many other fields of medicine, including reproductive medicine. The aim of the study was to determine the level of stress and strategies of coping with stress in patients treated for infertility. The study—using a questionnaire developed by the authors, the Perceived Stress Scale-10 (PSS-10), and the Coping Orientation to Problems Experienced Inventory (Mini-COPE)—was conducted among 456 people from infertile couples. Conclusions: More than half of the studied patients demonstrated a high level of stress. The choice of coping strategies was related to the respondents’ gender and level of stress as well as their experience with assisted reproductive technology.

show abstract

Section: Introductionmentioning

confidence: 99%

The Need of Personalized Medicine in Coping with Stress during Infertility Treatment

Nagórska

Obrzut

Ulman³

et al. 2021

JPM

View full text Add to dashboard Cite

show abstract

“…This is why there is an increasing need for personalizing diagnostic and therapeutic methods according to the condition of each infertile woman [ 5 ]. The concept of personalized medicine, also called precision medicine or molecular medicine, was applied with success in the management of gynecologic cancer and is currently gaining ground in the field of reproductive medicine, too [ 43 ].…”

Section: Implications In Research and Clinical Issues Related To Huma...mentioning

confidence: 99%

Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and Differences

Tesarik

2022

IJMS

View full text Add to dashboard Cite

Maternal-to-zygotic transition (MZT) of the control of early post-fertilization development is a key-event conditioning the fate of the future embryo, fetus and newborn. Because of the relative paucity of data concerning human embryos, due to ethical concerns and the poor availability of human embryos donated for research, most data have to be derived from animal models, among which those obtained using mouse embryos are most prevalent. However, data obtained by studies performed in non-mammalian specie can also provide useful information. For this reason, this review focuses on similarities and differences of MZT control mechanisms in humans and other species, with particular attention to the mouse. A number of molecular pathways controlling MZT in mice and humans are compared, pointing out those that could be at the origin of further focused experimental studies and the development of new diagnostic tools based on the translational medicine principles. Data concerning possible candidate molecules to be included in these studies are identified.

show abstract

“…Therefore, precision medicine has received more and more attention in recent years, which could significantly compensate for the shortcomings of conventional strategies ( Figure 2 ). Simply, patient’s sample-based multi-omics analysis could comprehensively demonstrate the underlying risk, suitable patients, novel drug targets, and promising combination therapies ( Zhang and Yu, 2020 ). Not only that, precision medicine will also accelerate the process of clinical transformation, the cells and patient-derived xenograft (PDX)-based drug screening could enhance the efficacy of clinical trials ( Wang et al, 2018a ).…”

Section: Nanomaterials Therapeutics Overcome Drug Resistancementioning

confidence: 99%

Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy

Cao¹,

Zhu²,

Wang

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Drug resistance is the most significant causes of cancer chemotherapy failure. Various mechanisms of drug resistance include tumor heterogeneity, tumor microenvironment, changes at cellular levels, genetic factors, and other mechanisms. In recent years, more attention has been paid to tumor resistance mechanisms and countermeasures. Nanomedicine is an emerging treatment platform, focusing on alternative drug delivery and improved therapeutic effectiveness while reducing side effects on normal tissues. Here, we reviewed the principal forms of drug resistance and the new possibilities that nanomaterials offer for overcoming these therapeutic barriers. Novel nanomaterials based on tumor types are an excellent modality to equalize drug resistance that enables gain more rational and flexible drug selectivity for individual patient treatment. With the emergence of advanced designs and alternative drug delivery strategies with different nanomaterials, overcome of multidrug resistance shows promising and opens new horizons for cancer therapy. This review discussed different mechanisms of drug resistance and recent advances in nanotechnology-based therapeutic strategies to improve the sensitivity and effectiveness of chemotherapeutic drugs, aiming to show the advantages of nanomaterials in overcoming of drug resistance for tumor chemotherapy, which could accelerate the development of personalized medicine.

show abstract

Precise Personalized Medicine in Gynecology Cancer and Infertility

Cited by 19 publications

References 82 publications

The Need of Personalized Medicine in Coping with Stress during Infertility Treatment

The Need of Personalized Medicine in Coping with Stress during Infertility Treatment

Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and Differences

Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy

Contact Info

Product

Resources

About