Precise ablation of skin with reduced collateral damage using the femtosecond-pulsed, terawatt titanium-sapphire laser

Imaging of nonlinear microscopy of burned skin treated by ultra-high intensity laser pulses

“…When comparing different images of SHG, we can observe a reduction of amount and distribution of collagen (red areas) in images. These results indicate a collagen degradation due to increase of temperature in burned site [7,14,18]. Over the monitoring days, red areas in SHG images increase appreciably.…”

“…After 14 days, for both treatments, collagen fibers have not yet reached the same organization of fiber in healthy skin. This could be explained because the maturation and remodeling of the scar begins during the fibroblastic phase and is characterized by reorganization of previously synthesized collagen and it continues for many (6)(7)(8)(9)(10)(11)(12) months post injury, gradually resulting in a mature scar [3]. Debridement is not a well-controlled method of tissue removal, while the volume and depth of tissue removal is predicted using femtosecond laser, allowing several scans, with no mechanical contact, virtually not depending on medical doctor skills and without infection risk.…”

Imaging of nonlinear microscopy of burned skin treated by ultra-high intensity laser pulses

“…When comparing different images of SHG, we can observe a reduction of amount and distribution of collagen (red areas) in images. These results indicate a collagen degradation due to increase of temperature in burned site [7,14,18]. Over the monitoring days, red areas in SHG images increase appreciably.…”

“…After 14 days, for both treatments, collagen fibers have not yet reached the same organization of fiber in healthy skin. This could be explained because the maturation and remodeling of the scar begins during the fibroblastic phase and is characterized by reorganization of previously synthesized collagen and it continues for many (6)(7)(8)(9)(10)(11)(12) months post injury, gradually resulting in a mature scar [3]. Debridement is not a well-controlled method of tissue removal, while the volume and depth of tissue removal is predicted using femtosecond laser, allowing several scans, with no mechanical contact, virtually not depending on medical doctor skills and without infection risk.…”

Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies

“…The locus of the optic fiber tip (5) is mapped in Zemax to simulate the path of the rays from the focal plane back through the objective. A PMMA insert (6) holds the fiber within the inner cavity of a cylindrical piezo-electric actuator (7). The actuator is centered within an outer 304SS casing (8) using an accurately turned epoxy plug (9).…”

Surgical applications of femtosecond lasers

“…Targets on the teeth are accessible because they are superficial, but the transparency of the eye permits access to its internal targets. While preliminary research is carried out in fields such as dermatology (both skin [46] and fingernail [47]) and otology (inner and middle ear [48]), this research has not yet generated a critical mass of interest, perhaps because other simpler laser systems or treatment methods exist.…”

Imaging of nonlinear microscopy of burned skin treated by ultra-high intensity laser pulses

“…When comparing different images of SHG, we can observe a reduction of amount and distribution of collagen (red areas) in images. These results indicate a collagen degradation due to increase of temperature in burned site [7,14,18]. Over the monitoring days, red areas in SHG images increase appreciably.…”

“…After 14 days, for both treatments, collagen fibers have not yet reached the same organization of fiber in healthy skin. This could be explained because the maturation and remodeling of the scar begins during the fibroblastic phase and is characterized by reorganization of previously synthesized collagen and it continues for many (6)(7)(8)(9)(10)(11)(12) months post injury, gradually resulting in a mature scar [3]. Debridement is not a well-controlled method of tissue removal, while the volume and depth of tissue removal is predicted using femtosecond laser, allowing several scans, with no mechanical contact, virtually not depending on medical doctor skills and without infection risk.…”

Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies

“…The locus of the optic fiber tip (5) is mapped in Zemax to simulate the path of the rays from the focal plane back through the objective. A PMMA insert (6) holds the fiber within the inner cavity of a cylindrical piezo-electric actuator (7). The actuator is centered within an outer 304SS casing (8) using an accurately turned epoxy plug (9).…”

Surgical applications of femtosecond lasers

“…Targets on the teeth are accessible because they are superficial, but the transparency of the eye permits access to its internal targets. While preliminary research is carried out in fields such as dermatology (both skin [46] and fingernail [47]) and otology (inner and middle ear [48]), this research has not yet generated a critical mass of interest, perhaps because other simpler laser systems or treatment methods exist.…”

Imaging of nonlinear microscopy of burned skin treated by ultra-high intensity laser pulses

“…When comparing different images of SHG, we can observe a reduction of amount and distribution of collagen (red areas) in images. These results indicate a collagen degradation due to increase of temperature in burned site [7,14,18]. Over the monitoring days, red areas in SHG images increase appreciably.…”

“…After 14 days, for both treatments, collagen fibers have not yet reached the same organization of fiber in healthy skin. This could be explained because the maturation and remodeling of the scar begins during the fibroblastic phase and is characterized by reorganization of previously synthesized collagen and it continues for many (6)(7)(8)(9)(10)(11)(12) months post injury, gradually resulting in a mature scar [3]. Debridement is not a well-controlled method of tissue removal, while the volume and depth of tissue removal is predicted using femtosecond laser, allowing several scans, with no mechanical contact, virtually not depending on medical doctor skills and without infection risk.…”

Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies

“…The locus of the optic fiber tip (5) is mapped in Zemax to simulate the path of the rays from the focal plane back through the objective. A PMMA insert (6) holds the fiber within the inner cavity of a cylindrical piezo-electric actuator (7). The actuator is centered within an outer 304SS casing (8) using an accurately turned epoxy plug (9).…”

Surgical applications of femtosecond lasers

“…Targets on the teeth are accessible because they are superficial, but the transparency of the eye permits access to its internal targets. While preliminary research is carried out in fields such as dermatology (both skin [46] and fingernail [47]) and otology (inner and middle ear [48]), this research has not yet generated a critical mass of interest, perhaps because other simpler laser systems or treatment methods exist.…”