Preauricular skin defects. A consequence of a persistent ectodermal groove

Drolet, Beth A.

doi:10.1001/archderm.133.12.1551

Archives of Dermatology

1997

DOI: 10.1001/archderm.133.12.1551

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Preauricular skin defects. A consequence of a persistent ectodermal groove

Beth A. Drolet

¹

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Cited by 34 publications

(39 citation statements)

References 12 publications

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38

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“…Our patient’s skin lesions differ to previously described skin lesions of FFDD in both location and the presence of the hair collar. Other authors have noted the same differences in their patients 13,16,17 . We propose these patients may constitute a distinct entity and are best considered as aplasia cutis congenita, not necessarily part of the FFDD.…”

Section: Discussionsupporting

confidence: 53%

“…While one investigator found elastic fibres to be absent in a preauricular lesion with a hair collar 13 our patient showed an increase in elastic tissue. Biopsies of two of 10 patients with preauricular lesions, many with a hair collar, showed flattened atrophic epidermis with replacement of dermis by loose connective tissue and notably absent adnexal structures 16 . Despite some differences in the dermal changes the epidermal and adnexal alterations are very similar.…”

Section: Discussionmentioning

confidence: 91%

“…The line of fusion of the maxillary and mandibular prominences corresponds to the areas of distribution of the facial defects of our patient. Several other patients have been reported with a similar distribution of facial lesions 13,16,17 . One author 16 suggests the rim of hair may be a marker for failure of ectodermal fusion embryologically.…”

Section: Discussionmentioning

confidence: 95%

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CASE REPORT Focal facial dermal dysplasia or aplasia cutis congenita: A case with a hair collar

Wells

¹

,

Weedon

²

2001

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Our patient’s skin lesions differ to previously described skin lesions of FFDD in both location and the presence of the hair collar. Other authors have noted the same differences in their patients 13,16,17 . We propose these patients may constitute a distinct entity and are best considered as aplasia cutis congenita, not necessarily part of the FFDD.…”

Section: Discussionsupporting

confidence: 53%

“…While one investigator found elastic fibres to be absent in a preauricular lesion with a hair collar 13 our patient showed an increase in elastic tissue. Biopsies of two of 10 patients with preauricular lesions, many with a hair collar, showed flattened atrophic epidermis with replacement of dermis by loose connective tissue and notably absent adnexal structures 16 . Despite some differences in the dermal changes the epidermal and adnexal alterations are very similar.…”

Section: Discussionmentioning

confidence: 91%

“…The line of fusion of the maxillary and mandibular prominences corresponds to the areas of distribution of the facial defects of our patient. Several other patients have been reported with a similar distribution of facial lesions 13,16,17 . One author 16 suggests the rim of hair may be a marker for failure of ectodermal fusion embryologically.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

CASE REPORT Focal facial dermal dysplasia or aplasia cutis congenita: A case with a hair collar

Wells

¹

,

Weedon

²

2001

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…It is postulated that defects in FFDD arise from incomplete ectoderm closure at facial embryonic fusion lines . Histologic examination of FFDD lesions shows similar features to membranous ACC, supporting the hypothesis that FFDD and ACC share an analogous pathogenesis …”

Section: Discussionmentioning

confidence: 72%

A case of focal facial dermal dysplasia type 4

Mehrtens

¹

,

Shankar

²

2018

Pediatric Dermatology

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…In five families, two members were affected, whereas three members belonging to three generations were affected in one family ( Fig. 2) The mode of inheritance is consistent with an autosomal dominant disorder in four families (1,3,4,6). In the other two families (2,5), the mode of inheritance is hard to ascertain.…”

Section: Case Reportsmentioning

confidence: 77%

Familial Nonmembranous Aplasia Cutis of the Scalp

Baselga

¹

,

Torrelo

²

,

Drolet

³

et al. 2005

Pediatric Dermatology

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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