Pre-Transplant Therapy in Experimental Heart Transplantation

Stojanović, Tomislav; Wagner, Andreas H.; Schöndube, Friedrich A.; Hecker, Markus

doi:10.5772/28531

Cited by 3 publications

(2 citation statements)

References 68 publications

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“…At least for the RNA decoys, this problem can be overcome by the intracellular expression of these molecules upon delivery of the respective genes. In addition, the DNA decoys are usually less efficient than the natural promoter DNA in binding a transcription factor, since, in the latter case, factor binding is stabilized by chromatin structure and interaction with the other proteins involved in transcription [87].…”

Section: Decoysmentioning

confidence: 99%

The Possibility of Nucleic Acids to Act as Anti-Viral Therapeutic Agents—A Review

Reza¹,

Mim²,

Quader³

et al. 2021

OJMM

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For just about 30 years, researchers have considered the likelihood to utilize nucleic acids as antiviral therapeutics. In principle, small single-stranded nucleotide sequence (oligonucleotide) could hybridize to a particular gene or messenger RNA and diminish transcription or translation, respectively, in this manner decreasing the amount of protein that is synthesized. Until now, an incredible number of antisense oligonucleotides, double-stranded oligonucleotides, aptamers, ribozymes, deoxyribozymes, interfering RNAs, chimeric RNA-DNA molecules, antibody genes has been created artificially and applied effectively for comprehension and manipulating biological processes and in clinical preliminaries to treat a variety of diseases. Their versatility and potency make them similarly fit candidates for fighting viral infections. However, troubles with their efficiency, off-target effects, toxicity, delivery, and stability halted the development of nucleic acid-based therapeutics that can be utilized in the clinic. The potential for nucleic acid therapeutic agents is significant and is quite recently beginning to be realized. In this review, we have summarized some of the recent advancements made in the area of nucleic acid based therapeutics and focused on the methods of their delivery and associated challenges.

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Section: Decoysmentioning

confidence: 99%

The Possibility of Nucleic Acids to Act as Anti-Viral Therapeutic Agents—A Review

Reza¹,

Mim²,

Quader³

et al. 2021

OJMM

View full text Add to dashboard Cite

show abstract

“…7). 122,123 Different chemical modications and/or delivery systems have been investigated in order to harness the therapeutic potential of the decoy ONs, which is usually hampered by their poor bioavailability and short half-life. 124 Phosphorothioate (PS) modied double-stranded ONs were reported to specically bind to transcription nuclear factor kappa beta (NF-kB).…”

Section: Decoy Oligonucleotidesmentioning

confidence: 99%