Pre-Surgery Status and in-Hospital Complications of Coronary Bypass Grafting in Prediabetes and Type 2 Diabetes Patients

Сумин, А. Н.; Безденежных, Н. А.; Безденежных, А. В.; Осокина, А. В.; Кузьмина, А. А.; Груздева, О. В.; Барбараш, О. Л.

doi:10.15829/1560-4071-2018-5-40-48

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…Nevertheless, the results of prospective studies can serve as indirect evidence in favor of the adverse effect of prediabetes on the state of both the arterial wall as a whole and the severity of atherosclerotic changes in it [ 31 , 32 , 33 ]. So, in a recent national cohort study in Korea, with a 12-year prospective observation, it was shown that the DM group showed the highest incidence and risk of vascular complications (cardiovascular, renal; and retinal), followed by the IFG group and the lowest risk was in group of normoglycemia [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Cardio-Ankle Vascular Index in the Persons with Pre-Diabetes and Diabetes Mellitus in the Population Sample of the Russian Federation

Sumin

Безденежных

et al. 2021

Diagnostics

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The aim of this study was to evaluate Cardio-Ankle Vascular Index (CAVI) and increased arterial stiffness predictors in patients with carbohydrate metabolism disorders (CMD) in the population sample of Russian Federation. Methods: 1617 patients (age 25–64 years) were enrolled in an observational cross-sectional study Epidemiology of Cardiovascular Diseases and Their Risk Factors in the Regions of the Russian Federation (ESSE-RF). The standard ESSE-RF protocol has been extended to measure the cardio-ankle vascular index (CAVI), a marker of arterial stiffness. Patients were divided into three groups: patients with type 2 diabetes mellitus (n = 272), patients with prediabetes (n = 44), and persons without CMD (n = 1301). Results: Median CAVI was higher in diabetes and prediabetes groups compared with group without CMD (p = 0.009 and p < 0.001, respectively). Elevated CAVI (≥9.0) was detected in 16.8% of diabetes patients, in 15.9% of those with prediabetes, and in 9.0% of those without CMD (p < 0.001). The factors affecting on CAVI did not differ in CVD groups. In logistic regression the visceral obesity, increasing systolic blood pressure (SBP) and decreasing glomerular filtration rate (GFR) were associated with a pathological CAVI in CMD patients, and age, diastolic blood pressure (DBP), and cholesterol in persons without CMD. Conclusions: the CAVI index values in the prediabetes and diabetes patients were higher than in normoglycemic persons in a population sample of the Russian Federation. Since the identified disorders of arterial stiffness in prediabetes are similar to those in diabetes, their identification is important to prevent further cardiovascular complications.

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Section: Discussionmentioning

confidence: 99%

Cardio-Ankle Vascular Index in the Persons with Pre-Diabetes and Diabetes Mellitus in the Population Sample of the Russian Federation

Sumin

Безденежных

et al. 2021

Diagnostics

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“…Учёными доказано, что активный скрининг перед коронарным шунтированием на дисгликемию позволяет дополнительно выявить около 9% пациентов с СД второго типа и 10% -предиабетом. Пациенты с предиабетом и СД второго типа имеют сопоставимый профиль госпитальных осложнений коронарного шунтирования, частота которых значимо превосходила таковую в группе без нарушений углеводного обмена [36]. Значение для развития субклинического атеросклероза имеет продолжительность предиабета [37], поскольку многие из атерогенных ФР уже присутствуют на предиабетической стадии [38].…”

Section: факторы риска и ассоциация с другими заболеваниямиunclassified

Modern Aspects of the Clinic, Diagnosis and Treatment of Prediabetes

Пырикова

Осипова

Полякова

2020

Arhivʺ vnutrennej mediciny

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Prediabetes is a common violation of carbohydrate metabolism, the medical and social relevance of which is due to the negative impact on the incidence of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD). The analyzed literature emphasizes the presence of a close pathogenetic relationship between type 2 DM/prediabetes and CVD. This relationship becomes even more relevant, taking into account, on the one hand, the persistent upward trend in the prevalence of carbohydrate metabolism disorders in the population, and on the other hand, the fact that in patients with dysglycemia it is cardiovascular complications that are the main cause of death. However, while the significance of type 2 DM as a risk factor for CVD is widely known and its presence immediately stratifies most patients to a group of high or very high cardiovascular risk, the contribution of prediabetes to the development of CVD remains underestimated among the therapeutic and cardiological communities. The high prevalence of prediabetes creates prerequisites for a further increase in the incidence of type 2 DM and CVD in the Russian Federation, which requires doctors of various specialties to be wary of early detection of prediabetes, since timely preventive measures can significantly reduce the risk of type 2 DM and its complications in the future. Currently, the effectiveness of both non-drug and drug strategies in preventing the development of type 2 DM in people with prediabetes has been confirmed, more and more data are accumulating about the possibility of effective prevention of CVD in prediabetes. According to modern research, the primary role of measures to actively change lifestyle in the treatment and prevention of prediabetes is emphasized, at the same time, the effectiveness of these measures can be reduced due to insufficient commitment of the patients themselves to their independent long-term implementation. Therefore, the strategy of prescribing metformin for the prevention of type 2 diabetes is absolutely justified if the doctor and patient recognize the inefficiency or inability to follow the recommendations for active lifestyle changes for a long time. The article presents the data on the etiology, epidemiology, diagnosis, and approaches to the management of patients with prediabetes from the standpoint of modern recommendations.

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“…Несмотря на существующие рутинные методы выявления нарушений углеводного обмена, в том числе СД, до сих пор эта патология выявляется на поздних стадиях (при наличии манифестирующих осложнений). Это утверждение иллюстрируют данные российского регистра NATION [15], а также результаты многочисленных исследований среди пациентов, направляемых на коронарные вмешательства, где выявление ранее недиагностированного СД было обычным явлением [16,17].…”

Section: материал обзораunclassified

Management of ischemic risk events in patients with multifocal atherosclerosis and type 2 diabetes mellitus

Барбараш¹,

Кашталап²

2020

Aterotromboz

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The review article presents current positions about prevalence of multifocal atherosclerosis and type 2 diabetes mellitus in patients with coronary artery disease (CAD). Existing approaches to the assessment and management of high risk of ischemic events in such patients are identified. Based on the results of clinical trials, the main positions have been identified on risk prevention of cardiovascular complications in patients with combination of multifocal atherosclerosis and type 2 diabetes mellitus. The results of the COMPASS study on the use of a combination of rivaroxaban 2.5 mg twice a day and a low dose of acetylsalicylic acid in patients with CAD and/or multifocal atherosclerosis are presented, which is accompanied by a significant reduction in the risk of cardiovascular events. This approach demonstrated a increase in the risk of massive bleedings, but mainly in the first year of treatment and without significant subsequent increase. At the same time, in the group of combination therapy rivaroxaban and acetylsalicylic acid there was no increase in the frequency of the most severe bleeding - fatal, intracranial and into the critical organs, compared to the group of monotherapy of acetylsalicylic acid. These two facts show a perfectly acceptable level of hemorrhagic risk for translation into real clinical practice. Hemorrhagic risk management capabilities were considered in a CoMPASS study by prescribing proton pump inhibitors to patients. The data on the COMPASS sub-analysis on evaluation of effectiveness and safety of combined antithrombotic therapy in patients with CAD and/or multifocal atherosclerosis and type 2 diabetes mellitus are presented. They showed the possibility of usage such approach in patient management in routine clinical practice. Patients with very high risk of ischemic events: ischemic heart disease and multifocal atherosclerosis, as well as type 2 diabetes mellitus, particularly need to improve approaches to antithrombotic therapy.

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Pre-Surgery Status and in-Hospital Complications of Coronary Bypass Grafting in Prediabetes and Type 2 Diabetes Patients

Cited by 8 publications

References 12 publications

Cardio-Ankle Vascular Index in the Persons with Pre-Diabetes and Diabetes Mellitus in the Population Sample of the Russian Federation

Cardio-Ankle Vascular Index in the Persons with Pre-Diabetes and Diabetes Mellitus in the Population Sample of the Russian Federation

Modern Aspects of the Clinic, Diagnosis and Treatment of Prediabetes

Management of ischemic risk events in patients with multifocal atherosclerosis and type 2 diabetes mellitus

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