2018
DOI: 10.1371/journal.pone.0205256
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Abstract: Immune priming in insects involves an initial challenge with a non-pathogenic microbe or exposure to a low dose of pathogenic microorganisms, which provides a certain degree of protection against a subsequent pathogenic infection. The protective effect of insect immune priming has been linked to the activation of humoral or cellular features of the innate immune response during the preliminary challenge, and these effects might last long enough to promote the survival of the infected animal. The fruit fly Dros… Show more

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Cited by 10 publications
(10 citation statements)
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“…To reliably produce infection phenotypes and assess the consequences in behaviour, we used a nano-injector to deliver precise volumes of bacterial solution into the abdomen of flies [42]. As a starting point, we chose three different non-pathogenic bacteria: ECC15, E. coli and M. luteus, which activate the fly's innate immune system without affecting lifespan [43][44][45]. Gram-negative bacteria ECC15 and E. coli induce the Imd pathway, while the gram-positive bacterium M. luteus activates the Toll pathway.…”
Section: Non-pathogenic Infections Do Not Affect Courtship Behaviour Of Wild-type Malesmentioning
confidence: 99%
“…To reliably produce infection phenotypes and assess the consequences in behaviour, we used a nano-injector to deliver precise volumes of bacterial solution into the abdomen of flies [42]. As a starting point, we chose three different non-pathogenic bacteria: ECC15, E. coli and M. luteus, which activate the fly's innate immune system without affecting lifespan [43][44][45]. Gram-negative bacteria ECC15 and E. coli induce the Imd pathway, while the gram-positive bacterium M. luteus activates the Toll pathway.…”
Section: Non-pathogenic Infections Do Not Affect Courtship Behaviour Of Wild-type Malesmentioning
confidence: 99%
“…There is considerable evidence supporting immune priming in invertebrates [reviewed in Contreras-Garduno et al (2016) and Milutinović and Kurtz (2016) ], with one mechanistic basis being haemocyte-mediated defences ( Pham et al, 2007 ; Rodrigues et al, 2010 ). However, a number of studies testing immune priming have not found evidence to support its existence ( Pham et al, 2007 ; Reber and Chapuisat, 2012 ; Longdon et al, 2013 ; Wu et al, 2015 ; Duneau et al, 2016 ; Patrnogic et al, 2018 ; Kutzer et al, 2019 ) [reviewed in Contreras-Garduno et al (2016) and Milutinović and Kurtz (2016) ]. It has been suggested that the inconsistent findings are due to heterogeneity in the way in which this phenomenon has been tested across studies ( Milutinović and Kurtz, 2016 ; Pradeu and Du Pasquier, 2018 ).…”
Section: Introductionmentioning
confidence: 99%
“…Protection sometimes is specific to the pathogen already encountered, but most often protection is conferred against other types of pathogens as well [ 7 , 8 , 9 , 10 , 11 ]. Although this kind of protection—often referred to as immune priming—occurs in multiple insect orders, it does not protect against all types of infection and it does not occur in all insects [ 12 , 13 , 14 , 15 ].…”
Section: Introductionmentioning
confidence: 99%