Pré‐condicionamento com dexmedetomidina protege contra lesão pulmonar em ratos com choque hemorrágico

Zhang, Lei; Wang, Wei; Qiao, Qianqian; Bu, Xue-Shan; Tang, Ling‐Hua; Jia, Yifan; Xia, Zhongyuan; Meng, Qingtao

doi:10.1016/j.bjan.2018.09.011

Cited by 3 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glutathione (GSH) is the main antioxidant in the lung and plays an important defense role in the corresponding oxidant-mediated inflammatory response and lung injury, and smoking can inhibit GSH [ 11 , 12 ]. Sympathetic excitation of the body after hemorrhagic shock promotes the secretion of catecholamines, leukotrienes, angiotensin, and endothelin by the renin-angiotensin system (RAS), while the coagulation-fibrinolytic system is also activated, all of which promote pulmonary vasoconstriction, causing a decrease in pulmonary blood flow and affecting capillary permeability, leading to ischemia-reperfusion injury in the lungs [ 13 , 14 ]. However, this study found that smoking history and pretransfusion shock were not independent risk factors for TRALI, which may be related to the small sample size of this study, which may have a certain impact on the stability of the logistic model, and it is easier to obtain negative results.…”

Section: Discussionmentioning

confidence: 99%

Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in Levels of Treg-Related Cytokines

Sun

Liu

2022

Emergency Medicine International

View full text Add to dashboard Cite

Objective. Analysis of clinical factors and changes in regulatory T cell (Treg)-related cytokine levels in transfusion-associated acute lung injury (TRALI). Methods. 62 patients who underwent blood transfusion and developed TRALI (TRALI group) in our hospital between January 2018 and December 2021 and 58 patients who did not develop TRALI (non-TRALI group) from blood transfusion were selected to collect clinical data from patients and construct a logistic regression model to analyze clinical risk factors for TRALI. Based on the prognosis of TRALI patients, they were divided into survival group (50 cases) and death group (12 cases), and serum CD4 + CD25 + Treg and Treg-related cytokines (interleukin 10 (IL-10), transforming growth factor-β (TGF-β)) levels were compared between the two groups, and the correlation between CD4 + CD25 + Treg and IL-10 and TGF-β was analyzed by Pearson. Results. The differences in smoking history, human leukocyte antigen (HLA) antibody II, pretransfusion shock, and CD4 + CD25 + Treg between the TRALI group and non-TRALI group were statistically significant ( P < 0.05 ). Logistic regression analysis showed that HLA antibody II and increased CD4 + CD25 + Treg were independent risk factors of TRALI ( P < 0.05 ). The levels of CD4 + CD25 + Treg, IL-10, and TGF-β in the death group were significantly higher than those in the survival group ( P < 0.05 ). CD4 + CD25 + Treg was positively correlated with levels of IL-10 and TGF-β ( P < 0.05 ). Conclusion. Elevated HLA antibody II and CD4 + CD25 + Treg are the main clinical risk factors for TRALI, and CD4 + CD25 + Treg may be involved in immunosuppression by increasing the expression levels of IL-10 and TGF-β. Early clinical monitoring of changes in Treg-related cytokine levels can provide some guidance for prognostic assessment of TRALI patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in Levels of Treg-Related Cytokines

Sun

Liu

2022

Emergency Medicine International

View full text Add to dashboard Cite

show abstract

Dexmedetomidine Attenuates Lung Injury in Toxic Shock Rats by Inhibiting Inflammation and Autophagy

Qin

2021

Archives of Medical Research

View full text Add to dashboard Cite

Pachymic Acid Prevents Hemorrhagic Shock-Induced Cardiac Injury by Suppressing M1 Macrophage Polarization and NF-κB Signaling Pathway

Liu,

Zhou,

Liu

et al. 2023

Am. J. Chin. Med.

View full text Add to dashboard Cite

Hemorrhagic shock (HS) is the leading cause of death in trauma patients. Inflammation following HS can lead to cardiac damage. Pachymic acid (PA), a triterpenoid extracted from Poria cocos, has been found to possess various biological activities, including anti-inflammatory and anti-apoptotic properties. Our research aims to investigate the protective effects of PA against HS-induced heart damage and the underlying mechanisms involved. Male Sprague-Dawley rats were intraperitoneally injected with PA (7.5 or 15[Formula: see text]mg/kg) daily for three days. Subsequently, we created a rat model of HS by drawing blood through a catheter inserted into the femoral artery followed by resuscitation. The results revealed that HS led to abnormalities in hemodynamics, serum cardiac enzyme levels, and cardiac structure, as well as induced cardiac apoptosis. However, pretreatment with PA effectively alleviated these effects. PA-pretreatment also suppressed mRNA and protein levels of interleukin (IL)-1[Formula: see text], IL-6, and tumor necrosis factor [Formula: see text] (TNF-[Formula: see text]) in the heart tissues of HS rats. Additionally, PA-pretreatment reduced inflammatory cell infiltration and M1 macrophage polarization while exaggerating M2 polarization in HS rat hearts. The study observed a decreased proportion of the expression of of M1 macrophages (CD86[Formula: see text]) and their marker (iNOS), along with an increased proportion of the expression of M2 macrophages (CD206[Formula: see text]) and their marker (Arg-1). Notably, PA-pretreatment suppressed NF-[Formula: see text]B pathway activation via inhibiting NF-[Formula: see text]B p65 phosphorylation and its nuclear translocation. In conclusion, PA-pretreatment ameliorates HS-induced cardiac injury, potentially through its inhibition of the NF-[Formula: see text]B pathway. Therefore, PA treatment holds promise as a strategy for mitigating cardiac damage in HS.

show abstract

Pré‐condicionamento com dexmedetomidina protege contra lesão pulmonar em ratos com choque hemorrágico

Cited by 3 publications

References 27 publications

Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in Levels of Treg-Related Cytokines

Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in Levels of Treg-Related Cytokines

Dexmedetomidine Attenuates Lung Injury in Toxic Shock Rats by Inhibiting Inflammation and Autophagy

Pachymic Acid Prevents Hemorrhagic Shock-Induced Cardiac Injury by Suppressing M1 Macrophage Polarization and NF-κB Signaling Pathway

Contact Info

Product

Resources

About