Pre-clinical anti-inflammatory aspects of a cuisine and medicinal millennial herb: Malva sylvestris L.

Abstract

Malva sylvestris has been used since ancient times for its emollient, laxative and anti-inflammatory properties, being extensively used as salads, soups and teas. The preset study evaluated the topical anti-inflammatory action of M. sylvestris hydroalcoholic extract (HE) and its compounds in mice ear inflammation caused by 12-O-tetradecanoylphorbol-acetate in mice. The LC-MS analysis of the HE confirmed the presence of scopoletin, quercetin and malvidin 3-glucoside compounds in the HE of M. sylvestris. Topical application of the HE reduced ear oedema, polymorphonuclear cells influx (myeloperoxydase activity and histological analysis) and interleukin-1β levels in the tissue. The topical application of the compound present in the HE, malvidin 3-glucoside was also able to inhibit ear oedema and leukocytes migration. The other tested compounds, scopoletin, quercetin and malvidin 3,5-glucoside were able to prevent the formation of oedema and cell infiltration, but with less effectiveness when compared to HE and malvidin 3-glucoside. Therefore, these results consistently support the notion that M. sylvestris leaves possesses topical anti-inflammatory activity, the compound malvidin 3-glucoside seems to be major responsible for this effect, with the participation of other anti-inflammatory compounds in the extract. Thus, as recommended by population, M. sylvestris can be used as a future treatment to skin disorders.

Malva species: Insights on its chemical composition towards pharmacological applications

“…The role of the aqueous extract from M. sylvestris aerial parts was assessed in rat models with induced inflammation (Sleiman & Daher, 2009). Later, it was confirmed that malvidin 3-glucoside appears to be the main responsible bioactive compound for the antiinflammatory effect (Prudente et al, 2013 (Ameri et al, 2016). Also, at the same time, a pronounced improvement in quality of life in HNC patients with radiation-induced xerostomia was observed (Heydarirad et al, 2017).…”

“…The role of the aqueous extract from M. sylvestris aerial parts was assessed in rat models with induced inflammation (Sleiman & Daher, ). Later, it was confirmed that malvidin 3‐glucoside appears to be the main responsible bioactive compound for the antiinflammatory effect (Prudente et al, ). Also, Martins et al suggested that M. sylvestris extracts antiinflammatory effects seem to be related to special antiinflammatory mediators induction—prostaglandins PGE 2 and PGD 2 (Martins et al, ).…”

Myogenic progenitors and imaging single-cell flow analysis: a model to study commitment of adult muscle stem cells

“…Further cells have been challenged with the known reference bioactive follistatin, a well-documented protein antagonist of myostatin and that stimulates myogenesis, used here as a positive control (Li et al 2007;Zhao and Hoffman 2008), and with a nutraceutical form of crude Malva sylvestris leaf extracts, our unknown in this study, that has been shown to exert anti-inflammatory and wound healing properties previously (Pirbalouti et al 2010;Prudente et al 2013).…”

Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity

“…Recently, it has also been reported that the extract of Malva sylvestris has wound-healing potential in alloxan-induced diabetic rats (Pirbalouti et al, 2010(Pirbalouti et al, , 2012. The extract of Malva sylvestris also has antiinflammatory and antiulcerogenic properties (Conforti et al, 2008;Sleiman and Daher, 2009;Pirbalouti et al, 2010;Gasparetto et al, 2012;Prudente et al, 2013).…”