Pre‐ and perinatal stress and irritable bowel syndrome in young adults – A nationwide register‐based cohort study

Olén, Ola; Stephansson, Olof; Bäckman, Anders; Törnblom, Hans; Simrén, Magnus; Altman, Maria

doi:10.1111/nmo.13436

Cited by 11 publications

(14 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The amount of premature births is increasing, and for the babies that survive, there is an increased risk of disability and neuropsychological disorders [ 9 ]. On the other hand, a Swedish nationwide register-based cohort study found preterm birth to be associated with a decreased risk for IBS among young adults [ 10 ]. However, since the maturation of a fetus’ different organ systems occur at unique paces (time periods), a difference of one gestational week could lead to significantly different future health problems [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

A possible association between early life factors and burden of functional bowel symptoms in adulthood

Wennerberg

Sharma

Nilsson

et al. 2021

Scandinavian Journal of Primary Health Care

View full text Add to dashboard Cite

Objective The studies of early life factors and development of functional bowel diseases show inconsistent results. We therefore examined associations between certain early life factors and functional bowel symptoms in adulthood. Design Population-based cross-sectional study. Setting Weight and height were measured and questionnaires were completed at the time point of enrollment in MOS. Subjects 1013 participants in the Malmö Offspring Study (MOS) without organic bowel disease with data available from the Swedish Medical Birth Registry. Main outcome measures Associations were calculated between gestational age, birth weight, small-for-gestational-age and Apgar score from the Birth Registry, and symptoms according to the visual analog scale for irritable bowel syndrome (VAS-IBS) (abdominal pain, diarrhea, constipation, bloating and flatulence, vomiting and nausea, and symptoms’ influence on daily life) or self-reported IBS using logistic regression. Results In all, 253 (25.0%) participants reported bowel symptoms during the past 2 weeks and 179 (17.7%) self-reported IBS; conditions which were strongly associated ( p < 0.001). Female sex and chronic stress were two independent factors more common among participants with bowel symptoms compared with asymptomatic participants ( p < 0.001). Early life factors were not associated with presence of overall bowel symptoms ( p = 0.080), any specific bowel symptoms or self-reported IBS. Lower birth weight ( p = 0.038) and being born small for gestational age ( p = 0.043) were associated with severe influence of intestinal symptoms on daily life in adulthood. Conclusions Lower birth weight and small for gestational age are not associated with the presence of overall bowel symptoms but with more pronounced influence of such symptoms on daily adult life. Key points Lower gestational age tended to be associated with functional bowel symptoms in adulthood. Lower birth weight and being small for gestational age are associated with increased negative influences of symptoms on daily life in adulthood. Patients born preterm or with low birth weights may be at increased risk to develop functional bowel symptoms later in life.

show abstract

Section: Introductionmentioning

confidence: 99%

A possible association between early life factors and burden of functional bowel symptoms in adulthood

Wennerberg

Sharma

Nilsson

et al. 2021

Scandinavian Journal of Primary Health Care

View full text Add to dashboard Cite

show abstract

“…These results further strengthen the concept that appropriate manipulation of the gut microbiome during adolescence, may reduce the probability of developing severe disorders that could affect the gut and the CNS later. This is all the more interesting in view of the worldwide increasing incidence of functional gastrointestinal disorders affecting the adolescent and young population [64,65].…”

Section: Discussionmentioning

confidence: 99%

Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice

et al. 2019

View full text Add to dashboard Cite

Antibiotic use during adolescence may result in dysbiosis-induced neuronal vulnerability both in the enteric nervous system (ENS) and central nervous system (CNS) contributing to the onset of chronic gastrointestinal disorders, such as irritable bowel syndrome (IBS), showing significant psychiatric comorbidity. Intestinal microbiota alterations during adolescence influence the expression of molecular factors involved in neuronal development in both the ENS and CNS. In this study, we have evaluated the expression of brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin-related kinase B (TrkB) in juvenile mice ENS and CNS, after a 2-week antibiotic (ABX) treatment. In both mucosa and mucosa-deprived whole-wall small intestine segments of ABX-treated animals, BDNF and TrKB mRNA and protein levels significantly increased. In longitudinal muscle-myenteric plexus preparations of ABX-treated mice the percentage of myenteric neurons staining for BDNF and TrkB was significantly higher than in controls. After ABX treatment, a consistent population of BDNF- and TrkB-immunoreactive neurons costained with SP and CGRP, suggesting up-regulation of BDNF signaling in both motor and sensory myenteric neurons. BDNF and TrkB protein levels were downregulated in the hippocampus and remained unchanged in the prefrontal cortex of ABX-treated animals. Immunostaining for BDNF and TrkB decreased in the hippocampus CA3 and dentate gyrus subregions, respectively, and remained unchanged in the prefrontal cortex. These data suggest that dysbiosis differentially influences the expression of BDNF-TrkB in the juvenile mice ENS and CNS. Such changes may potentially contribute later to the development of functional gut disorders, such as IBS, showing psychiatric comorbidity.

show abstract

“…The present study used a much more robust process to determine whether a subject had IBS according to international criteria or a previous medical diagnosis, compared to the previous study, which had simply asked if a subject had “diarrhoea, constipation, and painful abdominal distension,” which were then attributed to IBS. Others have also sought to reproduce the original report of an association between birth weight and IBS, however, despite a study of approximately 2 000 000 Swedish subjects no association was found 23,24 . It therefore seems very unlikely that there is an association between low birth weight and IBS, when the latter is accurately measured.…”

Section: Discussionmentioning

confidence: 99%

“…Age at the time of survey in years (mean, SD) 56.0 (13.9) an association between birth weight and IBS, however, despite a study of approximately 2 000 000 Swedish subjects no association was found. 23,24 It therefore seems very unlikely that there is an association between low birth weight and IBS, when the latter is accurately measured.…”

Section: Demographic Variable N (%)mentioning

confidence: 99%

The association between low birth weight, childhood recollections of parental response to illness, and irritable bowel syndrome: a twin study

Harvey

Theron

Smith

et al. 2020

Neurogastroenterology Motil

View full text Add to dashboard Cite

Irritable bowel syndrome (IBS) is a functional bowel disorder typically characterized by abdominal pain, altered bowel habit, and bloating. The current diagnostic criteria are described in the Rome IV guidelines. 1 Estimates of the prevalence of IBS in the UK vary based on diagnostic criteria; however, a recent large community study found 5.5% met the Rome IV criteria in the UK. 2 IBS is associated with significant healthcare costs estimated to be £90-£316 for each person with IBS in the UK. 3 The wider economy is impacted

show abstract

Pre‐ and perinatal stress and irritable bowel syndrome in young adults – A nationwide register‐based cohort study

Abstract: In this large population-based study, we found that mode of delivery was associated with an increased risk for IBS in young adulthood, while other proxies for pre- and perinatal stress were not. Female gender remains the most important risk factor for IBS.

Cited by 11 publications

References 35 publications

A possible association between early life factors and burden of functional bowel symptoms in adulthood

A possible association between early life factors and burden of functional bowel symptoms in adulthood

Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice

The association between low birth weight, childhood recollections of parental response to illness, and irritable bowel syndrome: a twin study

Contact Info

Product

Resources

About