2013
DOI: 10.1016/j.febslet.2013.09.046
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: a b s t r a c tThe membrane-bound Vanin-1 pantetheinase regulates tissue adaptation to stress. We investigated Vnn1 expression and its regulation in liver. Vnn1 is expressed by centrolobular hepatocytes. Using novel tools, we identify a soluble form of Vnn1 in mouse and human serum and show the contribution of a cysteine to its catalytic activity. We show that liver contributes to Vanin-1 secretion in serum and that PPARalpha is a limiting factor in serum Vnn1 production. Functional PPRE sites are identified i… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

3
54
0

Year Published

2014
2014
2024
2024

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 56 publications
(57 citation statements)
references
References 39 publications
(60 reference statements)
3
54
0
Order By: Relevance
“…PPAR null (Ppara-null) mice 9) were purchased from Jackson laboratories. All animals were housed in a temperature-controlled (24 ) facility with a 12-hour light/dark cycle (08:00 to 20:00 light) and allowed free access to water and standard hepatocyte cultures were maintained at 37 , 95% humidity and 5% CO2 for 3 hours and gently replaced with InVitroGRO CP with antibiotics. After 24 hours, the hepatocytes were treated with InVitroGRO CP with antibiotics containing 100 nM and 10 M of K-877, 100 M of fenofibric acid or 0.01% DMSO as a control.…”
Section: Animal Experimentsmentioning
confidence: 99%
See 1 more Smart Citation
“…PPAR null (Ppara-null) mice 9) were purchased from Jackson laboratories. All animals were housed in a temperature-controlled (24 ) facility with a 12-hour light/dark cycle (08:00 to 20:00 light) and allowed free access to water and standard hepatocyte cultures were maintained at 37 , 95% humidity and 5% CO2 for 3 hours and gently replaced with InVitroGRO CP with antibiotics. After 24 hours, the hepatocytes were treated with InVitroGRO CP with antibiotics containing 100 nM and 10 M of K-877, 100 M of fenofibric acid or 0.01% DMSO as a control.…”
Section: Animal Experimentsmentioning
confidence: 99%
“…The characteristics of the primary human hepatocytes and their upregulated by K-877 treatment are involved in carbohydrate and lipid metabolism (Table 3), of which Cyp4a31 19) , Pdk4 12) , Cidec 20) , Acot1 21) , Acot2 22) , Acot3 23) , Slc27a1 (FATP1) 13) , Vnn1 24,25) and Aqp3 26) have been reported to be PPARs target genes. On the other hand, K-877 treatment reduced the expression of phase enzymes and xenobiotic transporters, such as the Slco1a4, Sult1a1, Slc22a7 and Cyp2c54 genes 27) ( Table 4).…”
Section: K-877 Regulates Fatty Acid Metabolic Genes In Primary Human mentioning
confidence: 99%
“…However, in these studies, the role of PA on erythrocytes has not been investigated. Indeed, the Vnn1 isoform is secreted in the serum by hepatocytes 17 and accounts for most of the previously described serum PA. 18 The role of this isoform is totally unknown, and it may participate in the homeostasis of blood or endothelial cells. More specifically, it might contribute to erythrocyte survival under steady-state or stressed conditions.…”
mentioning
confidence: 99%
“…For example, VNN1 protects islet b-cells from streptozotocin-induced injury and regulates the development of type 1 diabetes (17). In the liver, the mRNA expression levels of VNN1, as well as its activity, are induced upon fasting (18,19). A clinical study showed that the concentrations of VNN1 in pooled human urine distinguished diabetic patients with macroalbuminuria from those with normal albuminuria (20).…”
mentioning
confidence: 99%