PPAR agonists as direct modulators of the vessel wall in cardiovascular disease

Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders

“…Like other nuclear receptors, PPARs, once activated, bind to consensus DNA sequences to regulate gene expression through transcriptional co-activation [4][5][6]. The PPAR subfamily comprises three isoforms: PPARα, PPARβ/δ and PPARγ, which share a structural homology [1,2,7,8]. PPARs are activated by small, lipophilic molecules and, in the cytoplasm, form heterodimers with the retinoid X receptor-α (RXR) to regulate gene expression [9].…”

Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders

“…Like other nuclear receptors, PPARs, once activated, bind to consensus DNA sequences to regulate gene expression through transcriptional co-activation [4][5][6]. The PPAR subfamily comprises three isoforms: PPARα, PPARβ/δ and PPARγ, which share a structural homology [1,2,7,8]. PPARs are activated by small, lipophilic molecules and, in the cytoplasm, form heterodimers with the retinoid X receptor-α (RXR) to regulate gene expression [9].…”

PPAR: a therapeutic target in Parkinson’s disease

“…1998; Berger and Moller 2002; Castrillo and Tontonoz 2004). The PPAR subfamily is comprised of three isoforms: PPAR‐α, PPAR‐β/δ and PPAR‐γ, and these isoforms share structural homology in various species (Desvergne and Wahli 1999; Bishop‐Bailey 2000; Buchan and Hassall 2000; Straus and Glass 2001). PPAR are activated by small, lipophilic compounds and form heterodimers with the retinoid X receptor‐α (RXR) in the cytoplasm for full activation (van Neerven and Mey 2007).…”

Fenofibrate, a peroxisome proliferator–activated receptor‐α agonist, exerts anticonvulsive properties

“…PPARα is one of three subtypes of the nuclear receptor PPAR family (Fruchart et al., 1999; Bishop‐Bailey, 2000; Buchan & Hassall, 2000; Heneka & Landreth, 2007). PPARα binds and is activated by both natural ligands such as fatty acids and eicosanoid derivates, and synthetic ligands such as hypolipidemic fibrates.…”

Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders

“…Like other nuclear receptors, PPARs, once activated, bind to consensus DNA sequences to regulate gene expression through transcriptional co-activation [4][5][6]. The PPAR subfamily comprises three isoforms: PPARα, PPARβ/δ and PPARγ, which share a structural homology [1,2,7,8]. PPARs are activated by small, lipophilic molecules and, in the cytoplasm, form heterodimers with the retinoid X receptor-α (RXR) to regulate gene expression [9].…”

PPAR: a therapeutic target in Parkinson’s disease

“…1998; Berger and Moller 2002; Castrillo and Tontonoz 2004). The PPAR subfamily is comprised of three isoforms: PPAR‐α, PPAR‐β/δ and PPAR‐γ, and these isoforms share structural homology in various species (Desvergne and Wahli 1999; Bishop‐Bailey 2000; Buchan and Hassall 2000; Straus and Glass 2001). PPAR are activated by small, lipophilic compounds and form heterodimers with the retinoid X receptor‐α (RXR) in the cytoplasm for full activation (van Neerven and Mey 2007).…”

Fenofibrate, a peroxisome proliferator–activated receptor‐α agonist, exerts anticonvulsive properties

“…PPARα is one of three subtypes of the nuclear receptor PPAR family (Fruchart et al., 1999; Bishop‐Bailey, 2000; Buchan & Hassall, 2000; Heneka & Landreth, 2007). PPARα binds and is activated by both natural ligands such as fatty acids and eicosanoid derivates, and synthetic ligands such as hypolipidemic fibrates.…”

Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders

“…Like other nuclear receptors, PPARs, once activated, bind to consensus DNA sequences to regulate gene expression through transcriptional co-activation [4][5][6]. The PPAR subfamily comprises three isoforms: PPARα, PPARβ/δ and PPARγ, which share a structural homology [1,2,7,8]. PPARs are activated by small, lipophilic molecules and, in the cytoplasm, form heterodimers with the retinoid X receptor-α (RXR) to regulate gene expression [9].…”

PPAR: a therapeutic target in Parkinson’s disease

“…1998; Berger and Moller 2002; Castrillo and Tontonoz 2004). The PPAR subfamily is comprised of three isoforms: PPAR‐α, PPAR‐β/δ and PPAR‐γ, and these isoforms share structural homology in various species (Desvergne and Wahli 1999; Bishop‐Bailey 2000; Buchan and Hassall 2000; Straus and Glass 2001). PPAR are activated by small, lipophilic compounds and form heterodimers with the retinoid X receptor‐α (RXR) in the cytoplasm for full activation (van Neerven and Mey 2007).…”

Fenofibrate, a peroxisome proliferator–activated receptor‐α agonist, exerts anticonvulsive properties

“…PPARα is one of three subtypes of the nuclear receptor PPAR family (Fruchart et al., 1999; Bishop‐Bailey, 2000; Buchan & Hassall, 2000; Heneka & Landreth, 2007). PPARα binds and is activated by both natural ligands such as fatty acids and eicosanoid derivates, and synthetic ligands such as hypolipidemic fibrates.…”