Povidone panniculitis. Polyvinylpyrrolidone panniculitis

Abstract

Multiple subcutaneous nodules and recurrent flu-like episodes developed in a 60-year-old woman after she had received local intramuscular injections of procaine povidone for a seven-year period. A skin biopsy specimen showed distinctive gray-blue material in the histiocytes in sections stained with hematoxylin-eosin. Povidone is an inert substance that may accumulate in multiple organs, including the skin. Its presence can be verified by its affinity for special stains or by spectrophotometric analysis. In our patient, ultrastructural study showed amorphous inrahistiocytic deposits in the tissues. -revious reports have indicated that this substance may eventually accumulate in noninjected skin sites and may lead to pulmonary and arthritic symptoms in some patients, but no other patients, to our knowledge, have had complications associated with fever.

Localized cutaneous polyvinylpyrrolidone storage disease mimicking cheilitis granulomatosa

“…Cutaneous PVP storage disease was first reported by Dupont and Lachapelle in 1964, which was caused by local injection of PVP containing posterior pituitary extracts for treating diabetes insipidus 6 . Similar cases of localized cutaneous PVP storage disease were reported to be caused by local injection of other PVP‐containing medications, mostly in the European literature 7–11 . Localized PVP storage disease in non‐injected skin sites caused by intravenous administration of PVP has been reported as well 12–14 .…”

Polyvinylpyrrolidone (Povidone) Storage in RX-Damaged Skin following Procaine-Povidone Intramuscular Injections

“…The histological findings revealed a massive accumulation in the subcutaneous tissue of a basophilic globular material, whose staining affinities were consistent with polyvinylpyrroli done. Kossard et al [12] described a very interesting similar observation; multiple subcutaneous nodules developed in the arms and in the buttocks in a 60-year-old woman after she had received local intramuscular injec tions of procaine-povidone for a 7-year period. In this particular case, the authors coined the term 'povidone panniculitis' because there were inter mittent episodes of swelling, redness and pain at previous sites of procainepovidone injections, malaise and temperature of unexplained origin.…”