Potentiometric Studies of Binary and Ternary Complexes Involving Cadmium(II) and Nitrilo‐Tris(Methyl Phosphonic Acid) with Amino Acids, peptides and DNA Constituents

Shoukry, Azza A.; Shoukry, Mohamed M.

doi:10.1002/adic.200790057

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…Cd(II) has been found to induce various pathological conditions, some of which may be fatal. Other conditions include cardiovascular diseases, hypertension and cancer [1]. The toxicology of cadmium (II) was noted to be governed by its interaction with an abundance of certain potential ligands in biological systems [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, biological activity and equilibrium studies of cadmium(II) with 2,6-diaminopyridine and various bio-relevant ligands

Shoukry

Al-Mhayawi

2013

Eur. J. Chem.

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KEYWORDSThe complexing properties of 2,6-diaminopyridine (DAP) with cadmium(II) were investigated via measuring pH (i.e., pH-metrically). Binary and ternary complexes of Cd(II) involving DAP and various biologically relevant ligands are investigated. The ligands used (L) were amino acids, dicarboxylic acids, amides and DNA unit constituents. The ternary complexes are formed by simultaneous reactions. The results showed the formation of Cd(DAP)(L) complexes with amino acids and dicarboxylic acids. Amides form both Cd(DAP)(L) complex and the corresponding deprotonated amide species Cd(DAP)(LH-1). The concentration distributions of the various complex species formed in solution were also evaluated as a function of pH. The effect of dioxane as a solvent on the protonation constant of DAP and the formation constants of Cd(II)-DAP complexes were discussed. The solid complexes [Cd(DAP)L)] where L = methionine and glycine, were isolated and characterized. The isolated solid complexes have also been screened for their antimicrobial activities against some selected bacteria and fungi. The activity data show that the complexes are found to have antibacterial and antifungal activity. Speciation Effect of solvent Bioactive ligands Stability constant 2,6-Diaminopyridine Antimicrobial activity

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, biological activity and equilibrium studies of cadmium(II) with 2,6-diaminopyridine and various bio-relevant ligands

Shoukry

Al-Mhayawi

2013

Eur. J. Chem.

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Complex Formation Reactions of Promethazine Copper(II) and Various Biologically Relevant Ligands. Synthesis, Equilibrium Constants, Spectroscopic Characterization and Biological Activity

Shoukry

2011

J Solution Chem

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Coordination properties of N,O-carboxymethyl chitosan (NOCC). Synthesis and equilibrium studies of some metal ion complexes. Ternary complexes involving Cu(II) with (NOCC) and some biorelevant ligand

Shoukry¹,

Hosny²

2011

Open Chemistry

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In the present study, the acid-base equilibria of N,O-carboxymethy chitosan abbreviated as (NOCC), is investigated. The complex formation equilibria with the metal ions Cu(II), Ni(II), Co(II), Mn(II), and Zn(II) are investigated potentiometrically. The stability constant values of the binary and ternary complexes formed in solution were determined and the binding centers of the ligands were assigned. The relationships between the properties of the studied central metal ions as ionic radius, electronegativity, atomic number, and ionization potential, and the stability constants of the formed complexes were investigated in an effort to give information about the nature of chemical bonding in complexes and make possible the calculation of unknown stability constants. Cu(II), Ni(II), and U(VI) complexes with NOCC are isolated as solid complexes and characterized by conventional chemical and physical methods. The structures of the isolated solid complexes are proposed on the basis of the spectral and magnetic studies. The ternary copper(II) complexes involving NOCC and various biologically relevant ligands containing different functional groups, as amino acids and DNA constituents are investigated. The stability constants of the complexes are determined and the concentration distribution diagrams of the complexes are evaluated.

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Potentiometric Studies of Binary and Ternary Complexes Involving Cadmium(II) and Nitrilo‐Tris(Methyl Phosphonic Acid) with Amino Acids, peptides and DNA Constituents

Cited by 3 publications

References 32 publications

Synthesis, characterization, biological activity and equilibrium studies of cadmium(II) with 2,6-diaminopyridine and various bio-relevant ligands

Synthesis, characterization, biological activity and equilibrium studies of cadmium(II) with 2,6-diaminopyridine and various bio-relevant ligands

Complex Formation Reactions of Promethazine Copper(II) and Various Biologically Relevant Ligands. Synthesis, Equilibrium Constants, Spectroscopic Characterization and Biological Activity

Coordination properties of N,O-carboxymethyl chitosan (NOCC). Synthesis and equilibrium studies of some metal ion complexes. Ternary complexes involving Cu(II) with (NOCC) and some biorelevant ligand

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