Potentiometric PVC membrane sensor for the determination of phenylephrine hydrochloride in some pharmaceutical products

Giahi, Masoud; Mirzaei, Maryam; Lahijani, G. Veghar

doi:10.1007/bf03246018

Cited by 9 publications

(3 citation statements)

References 14 publications

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“…In Table 4, analytical performance of the proposed CGE was compared with the corresponding values previously reported for usual polymeric membrane PE-selective electrodes [15,37]. As seen, the proposed CGE showed superior, in most cases, response characteristics and selectivity behavior to the previous polymeric membrane PE-selective electrodes.…”

Section: Potentiometric Selectivity Coefficientsmentioning

confidence: 67%

Development of a New Coated Graphite Phenylephrine Potentiometric Sensor and Its Applications to Pharmaceutical and Biological Analysis

Soleymanpour

Abdifar

Bani³

2011

Electroanalysis

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The construction and performance characteristics of a coated graphite phenylephrine-selective electrode based on incorporation of the ion-association complex of phenylephrine-tetraphenylborate in plasticized PVC matrix was studied. The electrode exhibited a Nernstian slope of 59.0 mV/decade to phenylephrine over a wide concentration range from 3.0 10 À6 to 5.6 10 À2 M with a low detection limit of 1.5 10 À6 M. The proposed electrode manifested advantages of fast response, long life time and, most important, good selectivities for phenylephrine relative to a wide variety of common foreign inorganic cations, anions and also organic species. The electrode was successfully applied to determine phenylephrine in adult cold tablets, phenylephrine eye-drops and also blood serum samples. The inclusion complex formation between a-and b-cyclodextrine and phenylephrine was studied potentiometrically by the proposed electrode.

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Section: Potentiometric Selectivity Coefficientsmentioning

confidence: 67%

Development of a New Coated Graphite Phenylephrine Potentiometric Sensor and Its Applications to Pharmaceutical and Biological Analysis

Soleymanpour

Abdifar

Bani³

2011

Electroanalysis

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“…Br À (Singh et al, 2006); SCN À (Chai et al, 2005); F À (Gorski et al, 2010), cation i.e. Fe(III) (Ekmekci et al, 2007); Cd(II) (Wardak, 2012;Khan and Alam, 2003); Cr(III) (Sharma and Goel, 2005); Pb(II) (Jeong et al, 2005;Lee et al, 2004); Cu(II) (Gholivand et al, 2007); Cs(I) (Peper et al, 2005) and drug molecules such as Prenalterol (Khalil and El-Reis, 2003); Hydralazine (Badawy et al, 1988); Biperiden (Khaled et al, 2011); Pethidine (Liu et al, 2002); Phenylephrine hydrochloride (Giahi et al, 2010); Bambuterol hydrochloride (Mostafa et al, 2011); Desipramine (Ensafi and Allafchian, 2011); and Atenolol (Nassory et al, 2007) yet there is still a need to carry out research to improve the ion-selective electrode's parameters such as detection limit, concentration range, pH range and life span to increase the usefulness of the electrode. Extensive efforts have been made to develop good sensitive ISEs for the determination of heavy metal ions.…”

Section: Introductionmentioning

confidence: 99%

Zirconium(IV) phosphosulphosalicylate-based ion selective membrane electrode for potentiometric determination of Pb(II) ions

Rashid

Khan

Lutfullah

et al. 2019

Arabian Journal of Chemistry

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Zirconium(IV) phosphosulphosalicylate, a cation exchanger was synthesized by mixing zirconium oxychloride to a mixture of 5-sulphosalicylic acid and phosphoric acid. The material showed good efficiency for the preparation of an ion-selective membrane electrode. The membrane was characterized affinity for Pb(II) ions. Due to its Pb(II) selective nature, the ion-exchanger was used as an electroactive by XRD and SEM analysis. The electrode responds to Pb(II) ions in a linear range from 1 · 10 À5 to 1 · 10 À1 M with a slope of 43.8 mV per decade change in concentration with detection limit of 4.78 · 10 À6 M. The life span of electrode was found to be 90 days. The proposed electrode showed satisfactory performance over a pH range of 4.0-6.5, with a fast response time of 15 s. The sensor has been applied to the determination of Pb(II) ions in water samples of different origins. It has also been used as indicator electrode in potentiometric titration of Pb(II) ion with EDTA. ª 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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“…Ever since Baum et al . [ 3 , 4 , 5 ] introduced the organic sensitive sensors in the seventies, apart from many studies about their significant role in analytical, environmental, industrial and biological fields, also a great amount of research has been done about the application of ISEs in the field of pharmaceutical sciences [ 6 , 7 , 8 , 9 ]. For example Coşofreţ et al .…”

Section: Introductionmentioning

confidence: 99%

Using Ion-Selective Electrodes to Study the Drug Release from Porous Cellulose Matrices

et al. 2012

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Polyvinyl chloride (PVC)-based solid-contact ion-selective electrodes (SC-ISEs), responding to propranolol hydrochloride (Pr+) and lidocaine hydrochloride (Ld+) cations as the model drugs with potassium tetrakis(4-chlorophenyl) borate (KTpClPB) as the ion exchanger, were studied. Different drug-polymer solutions were prepared with the model drugs, using different blend ratios of ethylcellulose (EC) and hydroxypropyl cellulose (HPC). Two different solid dosage forms were used. Polymer films were produced by solvent casting method and drug containing porous cellulose samples were prepared by depositing the drug-polymer solutions onto filter paper substrates. The quality of the electrodes and the release profile of Pr+ and Ld+ were investigated with the potentiometric method. The results were compared to UV spectrophotometry. The electrodes were found to be sensitive, precise and functional with a Nernstian behavior over the range of 1.0 × 10−3–3.1 × 10−6 M (9.2 × 10−4–3.0 × 10−1 mg/mL) and 1 × 10−3–2 × 10−6 M (5.4 × 10−4–2.7 × 10−1 mg/mL) at 25 °C for Pr+ and Ld+ sensitive electrodes, respectively. The dynamic response time for the electrodes was less than 10 s. The Pr+ release from porous filter paper was always higher than its equivalent film formulation. Also, lidocaine had higher and faster release from the samples with higher drug concentration. The comparison of the two analytical methods showed near identical results. The ISEs provided a powerful and flexible alternative to UV method in determination of drug release from porous cellulose substrates in a small scale dissolution testing.

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Potentiometric PVC membrane sensor for the determination of phenylephrine hydrochloride in some pharmaceutical products

Cited by 9 publications

References 14 publications

Development of a New Coated Graphite Phenylephrine Potentiometric Sensor and Its Applications to Pharmaceutical and Biological Analysis

Development of a New Coated Graphite Phenylephrine Potentiometric Sensor and Its Applications to Pharmaceutical and Biological Analysis

Zirconium(IV) phosphosulphosalicylate-based ion selective membrane electrode for potentiometric determination of Pb(II) ions

Using Ion-Selective Electrodes to Study the Drug Release from Porous Cellulose Matrices

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