Potentiation of Otoprotective Effect of Hydrocortisone Immobilized on Povidone Nanoparticles under Conditions of Intravenous Injection

Panevin, A. A.; Zhuravskii, S. G.

doi:10.1007/s10517-018-3990-4

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…Panevin Zhuravskii ( 49 ) used hydrocortisone suspension, in which particles from synthetic organic polymer, polyvinylpyrrolidone (povidone), served as the dispersed transporting system. DPOAE measurements revealed the prepared NPs' ability to protect the cochlea against the acute pathology induced by a single acoustic stimulation of 5 kHz frequency and 110–112 dB intensity in Wister rats.…”

Section: Previous Studiesmentioning

confidence: 99%

The Use of Nanoparticles in Otoprotection

Barbara

Covelli²,

Filippi³

et al. 2022

Front. Neurol.

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The inner ear can be insulted by various noxious stimuli, including drugs (cisplatin and aminoglycosides) and over-acoustic stimulation. These stimuli damage the hair cells giving rise to progressive hearing loss. Systemic drugs have attempted protection from ototoxicity. Most of these drugs poorly reach the inner ear with consequent ineffective action on hearing. The reason for these failures resides in the poor inner ear blood supply, the presence of the blood-labyrinthine barrier, and the low permeability of the round window membrane (RWM). This article presents a review of the use of nanoparticles (NPs) in otoprotection. NPs were recently used in many fields of medicine because of their ability to deliver drugs to the target organs or cells. The studies included in the review regarded the biocompatibility of the used NPs by in vitro and in vivo experiments. In most studies, NPs proved safe without a significant decrease in cell viability or signs of ototoxicity. Many nano-techniques were used to improve the drugs' kinetics and efficiency. These techniques included encapsulation, polymerization, surface functionalization, and enhanced drug release. In such a way, it improved drug transmission through the RWM with increased and prolonged intra-cochlear drug concentrations. In all studies, the fabricated drug-NPs effectively preserved the hair cells and the functioning hearing from exposure to different ototoxic stimuli, simulating the actual clinical circumstances. Most of these studies regarded cisplatin ototoxicity due to the wide use of this drug in clinical oncology. Dexamethasone (DEX) and antioxidants represent the most used drugs in most studies. These drugs effectively prevented apoptosis and reactive oxygen species (ROS) production caused by ototoxic stimuli. These various successful experiments confirmed the biocompatibility of different NPs and made it successfully to human clinical trials.

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Section: Previous Studiesmentioning

confidence: 99%

The Use of Nanoparticles in Otoprotection

Barbara

Covelli²,

Filippi³

et al. 2022

Front. Neurol.

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“…In this case, hydrocortisone entrapped povidone (polyvinylpyrrolidone) NPs were injected intravenously subsequent acoustic stimulation at 110 dB noise for 2 hr at 5 kHz frequency and the amplitude of otoacoustic emission was recorded on 1 and 24 hr and 7 days after the noise trauma at 4-6.4 kHz frequency resulted in relatively better otoprotective effect of single injection hydrocortisone-povidone NPs within 1 day than those of free drug. 163 120 disorder in both adult and young population. Therefore, conservation of leftover hair cells and restoration of damaged hair cell from ototoxicity and noise trauma are one of the crucial tasks for pharmacotherapy.…”

Section: Noise-induced Hearing Loss (Nihl)mentioning

confidence: 99%

An Overview of Nanoparticle Drug Delivery for Ototoxin and Noise Mediated Hearing Loss Treatment

Sreeharsha¹,

Nataraj²,

Jang³

et al. 2022

Ind. J. Pharm. Edu. Res

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Efficient delivery of therapeutic material to target site of the inner ear is considered as the most challenging process due to their poor blood flow and inaccessibility sensitivity towards chemical stimuli, inability of drug to be delivered as well. Novel nanoparticlebased drug transport approaches have emerged for overcoming the restriction associated with inner ear therapeutic material delivery. The main focus of this article is to highlight the potential benefits, pre-clinical level otoprotective effect of different types of NPs based payload delivery strategies in mitigating sensorineural hearing impairment resulting from medication (cisplatin and antibiotic treatment) and noise exposure. This review converses about advantage of nanocarrier assisted targeted cell specific inner ear drug delivery approach and demonstrates that targeted NPs delivery systems have the capability to be utilized as vehicle to transport therapeutic materials into the OHCs within the cochlea in controlled and sustained way and maximize following therapeutic effects. Efficacy of systemic and minimally invasive intratympanic and RWM approach for delivering steroids/ genetic material to the inner ear has also been compared in this article. Understanding the importance (design, formulation, cochlear biocompatibility and cell specific binding efficiency of NPs, mechanistic pathways, route of delivery, positive therapeutic outcomes) and hitches (adverse effects after treatment, negative therapeutic outcome) of currently available NPs based drug delivery systems offer new opportunity to develop best treatment methods for sensorineural hearing dysfunction.

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