Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid

Teelucksingh, Surujpal; Mackie, Anna; Burt, D.; Edwards, C. R. W.; MclNTYRE, Margaret A.; Brett, L

doi:10.1016/0140-6736(90)92633-s

Cited by 195 publications

(80 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observations that nonselective 11␤HSD inhibitors influence vascular tone (27,46) can be attributed to effects on the 11␤HSD-2 isozyme that catalyses inactivation of glucocorticoids within endothelial cells (15,22). Here, we show that regeneration of glucocorticoids by 11␤HSD-1 in isolated aortae amplifies their angiostatic effect.…”

Section: Discussionmentioning

confidence: 73%

Preventing local regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 enhances angiogenesis

Small

Hadoke

Sharif

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

109

155

View full text Add to dashboard Cite

Angiogenesis restores blood flow to healing tissues, a process that is inhibited by high doses of glucocorticoids. However, the role of endogenous glucocorticoids and the potential for antiglucocorticoid therapy to enhance angiogenesis is unknown. Using in vitro and in vivo models of angiogenesis in mice, we examined effects of (i) endogenous glucocorticoids, (ii) blocking endogenous glucocorticoid action with the glucocorticoid receptor antagonist RU38486, and (iii) abolishing local regeneration of glucocorticoids by the enzyme 11␤-hydroxysteroid dehydrogenase type 1 (11␤HSD1). Glucocorticoids, administered at physiological concentrations, inhibited angiogenesis in an in vitro aortic ring model and in vivo in polyurethane sponges implanted s.c. RU38486-enhanced angiogenesis in s.c. sponges, in healing surgical wounds, and in the myocardium of mice 7 days after myocardial infarction induced by coronary artery ligation. 11␤HSD1 knockout mice showed enhanced angiogenesis in vitro and in vivo within sponges, wounds, and infarcted myocardium. Endogenous glucocorticoids, including those generated locally by 11␤HSD1, exert tonic inhibition of angiogenesis. Inhibition of 11␤HSD1 in liver and adipose has been advocated to reduce cardiovascular risk in the metabolic syndrome: these data suggest that 11␤HSD1 inhibition offers a previously uncharacterized therapeutic approach to improve healing of ischemic or injured tissue. myocardial infarction ͉ wound healing

show abstract

Section: Discussionmentioning

confidence: 73%

Preventing local regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 enhances angiogenesis

Small

Hadoke

Sharif

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

109

155

View full text Add to dashboard Cite

show abstract

“…The influence of 11b-HSDs on vascular function has been addressed using non-selective enzyme inhibitors (80)(81)(82)(83), antisense knockdown (84) and in global 'knockout' mice (68,85) but not yet by cell-specific manipulations of 11b-HSDs. While loss of 11b-HSD2 dehydrogenase inactivation of glucocorticoid in the endothelium was associated with enhanced vasoconstrictor responses, loss of 11b-HSD1 reductase regeneration of glucocorticoid in vascular smooth muscle did not influence vascular tone.…”

Section: Glucocorticoid Signalling In Cardiovascular Organsmentioning

confidence: 99%

Glucocorticoids and Cardiovascular Disease

Walker¹

2007

European Journal of Endocrinology

466

386

View full text Add to dashboard Cite

Chronic excessive activation of glucocorticoid receptors induces obesity, insulin resistance, glucose intolerance, dyslipidaemia and hypertension. Subtle abnormalities of the hypothalamic-pituitaryadrenal axis and/or of tissue sensitivity to glucocorticoids are also associated with these cardiovascular risk factors in patients with the metabolic syndrome. Furthermore, glucocorticoids have direct effects on the heart and blood vessels, mediated by both glucocorticoid and mineralocorticoid receptors and modified by local metabolism of glucocorticoids by the 11b-hydroxysteroid dehydrogenase enzymes. These effects influence vascular function, atherogenesis and vascular remodelling following intravascular injury or ischaemia. This article reviews the systemic and cardiovascular effects of glucocorticoids, and the evidence that glucocorticoids not only promote the incidence and progression of atherogenesis but also modify the recovery from occlusive vascular events and intravascular injury. The conclusion is that manipulation of glucocorticoid action within metabolic and cardiovascular tissues may provide novel therapeutic avenues to combat cardiovascular disease.European Journal of Endocrinology 157 545-559

show abstract

“…Liquorice has been shown to increase plasma concentrations of prednisolone [22,23]. It also potentiated the cutaneous vasoconstrictor response of hydrocortisone [24]. Licorice is a common herb in Chinese and Japanese herbal mixtures.…”

Section: Discussionmentioning

confidence: 99%

Herb–drug interactions: Review and assessment of report reliability

Fugh‐Berman

Ernst

2001

Brit J Clinical Pharma

316

202

View full text Add to dashboard Cite

Aims The aim of this systematic review was to assess the published clinical evidence on interactions between herbal and conventional drugs. Methods Four electronic databases were searched for case reports, case series or clinical trials of such interactions. The data were extracted and validated using a scoring system for interaction probability. Results One hundred and eight cases of suspected interactions were found. 68.5% were classi®ed as`unable to be evaluated', 13% as`well-documented' and 18.5% as possible' interactions. Warfarin was the most common drug (18 cases) and St John's wort the most common herb (54 cases) involved. Conclusion Herb±drug interactions undoubtedly do occur and may put individuals at risk. However our present knowledge is incomplete and more research is urgently needed.

show abstract

Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid

Cited by 195 publications

References 22 publications

Preventing local regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 enhances angiogenesis

Preventing local regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 enhances angiogenesis

Glucocorticoids and Cardiovascular Disease

Herb–drug interactions: Review and assessment of report reliability

Contact Info

Product

Resources

About