Potentiation of anti-Alzheimer activity of curcumin by probiotic Lactobacillus rhamnosus UBLR-58 against scopolamine-induced memory impairment in mice

Patel, Chirag; Pande, Sonal; Acharya, Sanjeev

doi:10.1007/s00210-020-01904-3

Cited by 28 publications

(15 citation statements)

References 41 publications

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“…It regulates neurogenesis in the hippocampus and protects dopaminergic neurons by activating nuclear factor erythroid 2-related factor (Nrf2), the master regulator of the antioxidant response [ 24 , 26 , 34 , 103 ] It also upregulates β-tubulin, neuroD1, doublecortin (DCX), neurogenin, neuroligin, and neuregulin and downregulates the signal transducer and activator of transcription 3 (Stat3) [ 104 ]. These processes lead to improved memory retention [ 84 , 89 , 105 , 106 , 107 ] as was achieved with the application of 50 mg/kg of curcumin for 3 months or 200 mg/kg of curcumin for 45 days to transgenic mice [ 106 , 108 ]. Yin et al [ 109 ] demonstrated that curcumin improved cognitive function via the promotion of axonal regeneration.…”

Section: Curcuminmentioning

confidence: 99%

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Ege

2021

Materials

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AD is a chronic neurodegenerative disease. Many different signaling pathways, such as Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer’s disease and crosstalk between themselves. A promising treatment involves the uses of flavonoids, and one of the most promising is curcumin; however, because it has difficulty permeating the blood–brain barrier (BBB), it must be encapsulated by a drug carrier. Some of the most frequently studied are lipid nanocarriers, liposomes, micelles and PLGA. These carriers are further conjugated with brain-targeting agents such as lactoferrin and transferrin. In this review paper, curcumin and its therapeutic effects, which have been examined in vivo, are analyzed and then the delivery systems to the brain are addressed. Overall, the analysis of the literature revealed great potential for curcumin in treating AD and indicated the challenges that require further research.

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Section: Curcuminmentioning

confidence: 99%

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Ege

2021

Materials

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“…Similarly, Patel and co-workers (2020) witness that Lactobacillus rhamnosus UBLR-58 could increase SOD, GPx, and CAT in brain tissue, thereby acting as an antioxidant agent [ 88 ]. A study conducted by Cogliati and co-workers (2020) on the efficacy of Bacillus subtilis NCIB3610 and Escherichia soli OP50 on AD model of Caenorhabditis elegans shows favourable results as well.…”

Section: Discussionmentioning

confidence: 99%

Probiotics for Alzheimer’s Disease: A Systematic Review

et al. 2021

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Alzheimer’s disease (AD) is the most common form of neurodegenerative disorders affecting mostly the elderly. It is characterized by the presence of Aβ and neurofibrillary tangles (NFT), resulting in cognitive and memory impairment. Research shows that alteration in gut microbial diversity and defects in gut brain axis are linked to AD. Probiotics are known to be one of the best preventative measures against cognitive decline in AD. Numerous in vivo trials and recent clinical trials have proven the effectiveness of selected bacterial strains in slowing down the progression of AD. It is proven that probiotics modulate the inflammatory process, counteract with oxidative stress, and modify gut microbiota. Thus, this review summarizes the current evidence, diversity of bacterial strains, defects of gut brain axis in AD, harmful bacterial for AD, and the mechanism of action of probiotics in preventing AD. A literature search on selected databases such as PubMed, Semantic Scholar, Nature, and Springer link have identified potentially relevant articles to this topic. However, upon consideration of inclusion criteria and the limitation of publication year, only 22 articles have been selected to be further reviewed. The search query includes few sets of keywords as follows. (1) Probiotics OR gut microbiome OR microbes AND (2) Alzheimer OR cognitive OR aging OR dementia AND (3) clinical trial OR in vivo OR animal study. The results evidenced in this study help to clearly illustrate the relationship between probiotic supplementation and AD. Thus, this systematic review will help identify novel therapeutic strategies in the future as probiotics are free from triggering any adverse effects in human body.

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“…Both the probiotic and the placebo will be administered after breakfast for ten weeks under identical conditions. The probiotic strains selected have shown to be effective in similar populations or in cognitive function (Agahi et al, 2018; Czajeczny et al, 2021; Kelly et al, 2017; Mehrabadi & Sadr, 2020; Oh et al, 2020; Patel et al, 2020; Sanborn et al, 2020; Yang et al, 2020), and the time duration has been predicted based on previous studies exploring the influence of probiotics on cognitive and emotional functions (Ruiz‐Gonzalez et al, 2021). Assessments will be conducted in three stages: at the start of the trial, following the intervention (10 weeks), and at study end (20 weeks).…”

Section: Methodsmentioning

confidence: 99%

Effects of probiotics on cognitive and emotional functions in healthy older adults: Protocol for a double‐blind randomized placebo‐controlled crossover trial

Ruiz‐González

Cardona

Rodriguez‐Arrastia

et al. 2022

Research in Nursing & Health

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Ageing is a process that includes changes in cognitive and emotional functions, as well as changes in the diversity and integrity of gut microbiota. Probiotic treatments have recently been studied as a potential new therapeutic approach to alleviate a wide range of problems in other populations; however, clinical studies in older adults remain insufficient and limited. Thus, the aim of this project is to evaluate the efficacy of a multispecies probiotic formulation as a therapeutic strategy for attenuating the emotional and cognitive decline associated with ageing in adults over the age of 55. This is a doubleblind randomised placebo-controlled crossover trial involving at least 32 older adults and comparing two conditions: (a) probiotic, providing a multi-species probiotic for 10 weeks (Lactobacillus rhamnosus and Bifidobacterium lactis); and (b) placebo, receiving a harmless substance (potato starch). Despite the increasing use of probiotics for the treatment of cognitive and emotional problems, no study has yet focused on this group, to the best of our knowledge. Therapeutic strategies of the kind outlined in this protocol will help to shed light on the current state of knowledge about this topic, as well as promote health programs tailored to this population, which would encourage active ageing and healthy lifestyles. Not only do we expect improvements in the emotional dimension in terms of anxiety, stress, depression, and sleep quality, we also expect improvements in the cognitive dimension in terms of attention, memory, and decreased impulsivity.

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Potentiation of anti-Alzheimer activity of curcumin by probiotic Lactobacillus rhamnosus UBLR-58 against scopolamine-induced memory impairment in mice

Cited by 28 publications

References 41 publications

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Probiotics for Alzheimer’s Disease: A Systematic Review

Effects of probiotics on cognitive and emotional functions in healthy older adults: Protocol for a double‐blind randomized placebo‐controlled crossover trial

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