Potentials of lncRNA–miRNA–mRNA networks as biomarkers for laryngeal squamous cell carcinoma

Lv, Yan; Wang, Yanhua; Zhang, Zhikai

doi:10.1007/s13577-022-00799-x

Cited by 9 publications

(5 citation statements)

References 134 publications

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“…Conversely, miRNAs can also target and regulate the expression of lncRNAs. Furthermore, miRNAs can exert their effects on downstream messenger RNAs (mRNAs) through transcriptional or post-transcriptional mechanisms, thereby influencing various physiopathological processes in LSCC [ 83 ]. The intricate interplay between lncRNAs, miRNAs, and mRNAs forms complex cross-regulatory networks that play a significant role in the tumorigenesis and progression of LSCC.…”

Section: Discussionmentioning

confidence: 99%

Updates on Larynx Cancer: Risk Factors and Oncogenesis

Liberale,

Soloperto,

Marchioni

et al. 2023

IJMS

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Laryngeal cancer is a very common tumor in the upper aero-digestive tract. Understanding its biological mechanisms has garnered significant interest in recent years. The development of laryngeal squamous cell carcinoma (LSCC) follows a multistep process starting from precursor lesions in the epithelium. Various risk factors have been associated with laryngeal tumors, including smoking, alcohol consumption, opium use, as well as infections with HPV and EBV viruses, among others. Cancer development involves multiple steps, and genetic alterations play a crucial role. Tumor suppressor genes can be inactivated, and proto-oncogenes may become activated through mechanisms like deletions, point mutations, promoter methylation, and gene amplification. Epigenetic modifications, driven by miRNAs, have been proven to contribute to LSCC development. Despite advances in molecular medicine, there are still aspects of laryngeal cancer that remain poorly understood, and the underlying biological mechanisms have not been fully elucidated. In this narrative review, we examined the literature to analyze and summarize the main steps of carcinogenesis and the risk factors associated with laryngeal cancer.

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Section: Discussionmentioning

confidence: 99%

Updates on Larynx Cancer: Risk Factors and Oncogenesis

Liberale,

Soloperto,

Marchioni

et al. 2023

IJMS

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“…According to pathological classifications, squamous cell carcinoma accounts for 85%-96% of laryngeal cancer cases, making it one of the most common malignant tumors of the head and neck ( 123 ). Given its involvement in LSCC proliferation and invasion, circRNA has emerged as a viable target for LSCC treatment and detection ( 124 ).…”

Section: Roles and Mechanisms Of Circrna In Respiratory Cancersmentioning

confidence: 99%

Roles and mechanisms of circular RNA in respiratory system cancers

Yang,

Jiao,

Zhang

et al. 2024

Front. Oncol.

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Circular RNAs (circRNAs) constitute a class of endogenous non-coding RNAs (ncRNAs) that lack a 5’-ended cap and 3’-ended poly (A) tail and form a closed ring structure with covalent bonds. Due to its special structure, circRNA is resistant to Exonuclease R (RNaseR), making its distribution in the cytoplasm quite rich. Advanced high-throughput sequencing and bioinformatics methods have revealed that circRNA is highly conserved, stable, and disease- and tissue-specific. Furthermore, increasing research has confirmed that circRNA, as a driver or suppressor, regulates cancer onset and progression by modulating a series of pathophysiological mechanisms. As a result, circRNA has emerged as a clinical biomarker and therapeutic intervention target. This article reviews the biological functions and regulatory mechanisms of circRNA in the context of respiratory cancer onset and progression.

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“…10 New research findings have revealed that the dysregulation of lncRNA expression contributes to the developing HCC and the subsequent formation of metastasis. [11][12][13][14][15][16] It is noted that competing endogenous RNAs (ceRNAs) has been identified to mediate lncRNA activity. In this model, lncRNA or mRNA harboring the same miRNA response element can modulate each other's expression levels by competitively binding to shared miRNAs that block target mRNAs.…”

Section: Introductionmentioning

confidence: 99%

“…Increasing evidence suggests that lncRNAs are not only involved in gene expression regulations but also implicated in several biological and pathological processes, such as tumor development and its progression 10 . New research findings have revealed that the dysregulation of lncRNA expression contributes to the developing HCC and the subsequent formation of metastasis 11–16 . It is noted that competing endogenous RNAs (ceRNAs) has been identified to mediate lncRNA activity.…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNAFOXD1‐AS1 modulated CTCs epithelial‐mesenchymal transition and immune escape in hepatocellular carcinoma in vitro by sponging miR‐615‐3p

Guo,

Zheng,

Jiang

et al. 2024

Cancer Reports

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BackgroundHepatocellular carcinoma (HCC) is widely recognized as a globally prevalent malignancy. Immunotherapy is a promising therapy for HCC patients. Increasing evidence suggests that lncRNAs are involved in HCC progression and immunotherapy.AimThe study reveals the mechanistic role of long non‐coding RNA (lncRNA) FOXD1‐AS1 in regulating migration, invasion, circulating tumor cells (CTCs), epithelial‐mesenchymal transition (EMT), and immune escape in HCC in vitro.MethodsThis study employed real‐time PCR (RT‐qPCR) to measure FOXD1‐AS1, miR‐615‐3p, and programmed death‐ligand 1 (PD‐L1). The interactions of FOXD1‐AS1, miR‐615‐3p, and PD‐L1 were validated via dual‐luciferase reporter gene and ribonucleoprotein immunoprecipitation (RIP) assay. In vivo experimentation involves BALB/c mice and BALB/c nude mice to investigate the impact of HCC metastasis.ResultsThe upregulation of lncRNA FOXD1‐AS1 in malignant tissues significantly correlates with poor prognosis. The investigation was implemented on the impact of lncRNA FOXD1‐AS1 on the migratory, invasive, and EMT of HCC cells. It has been observed that the lncRNA FOXD1‐AS1 significantly influences the generation and metastasis of MCTC in vivo analysis. In mechanistic analysis, lncRNA FOXD1‐AS1 enhanced immune escape in HCC via upregulation of PD‐L1, which acted as a ceRNA by sequestering miR‐615‐3p. Additionally, lncRNA FOXD1‐AS1 was found to modulate the EMT of CTCs through the activation of the PI3K/AKT pathway.ConclusionThis study presents compelling evidence supporting the role of lncRNA FOXD1‐AS1 as a miRNA sponge that sequesters miR‐655‐3p and protects PD‐L1 from suppression.

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Potentials of lncRNA–miRNA–mRNA networks as biomarkers for laryngeal squamous cell carcinoma

Cited by 9 publications

References 134 publications

Updates on Larynx Cancer: Risk Factors and Oncogenesis

Updates on Larynx Cancer: Risk Factors and Oncogenesis

Roles and mechanisms of circular RNA in respiratory system cancers

Long non‐coding RNAFOXD1‐AS1 modulated CTCs epithelial‐mesenchymal transition and immune escape in hepatocellular carcinoma in vitro by sponging miR‐615‐3p

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