Potential Toxicity of Mitomycin C

Corneal Decompensation Following Bleb Revision With Absolute Alcohol: Clinical Pathological Correlation

“…This finding is consistent with numerous reports of corneal toxicity in humans following exposure to a number of agents, including preservatives, medications, irrigating solutions, and sterilizing agents. 3,4 The severity of the reaction is similar to that of mitomycin C. 5 It is also consistent with reports of corneal decompensation following inadvertent exposure of the corneal endothelium to alcohol in monkeys during perfusion experiments (oral communication, Paul Kaufman, September 2003). Experiments with corneal epithelium have shown that toxicity occurs in cadaver eyes with exposures of 20% ethanol for 45 seconds 6 and in immortalized epithelial cell lines with exposure of 20% ethanol for more than 30 seconds or with 20-second exposures of ethanol concentrations above 25%.…”

Corneal Decompensation Following Bleb Revision With Absolute Alcohol: Clinical Pathological Correlation

“…This finding is consistent with numerous reports of corneal toxicity in humans following exposure to a number of agents, including preservatives, medications, irrigating solutions, and sterilizing agents. 3,4 The severity of the reaction is similar to that of mitomycin C. 5 It is also consistent with reports of corneal decompensation following inadvertent exposure of the corneal endothelium to alcohol in monkeys during perfusion experiments (oral communication, Paul Kaufman, September 2003). Experiments with corneal epithelium have shown that toxicity occurs in cadaver eyes with exposures of 20% ethanol for 45 seconds 6 and in immortalized epithelial cell lines with exposure of 20% ethanol for more than 30 seconds or with 20-second exposures of ethanol concentrations above 25%.…”

Ologen implant versus mitomycin C in combined trabeculectomy and phacoemulsification

“…MMC has been shown to cause have toxic intraocular effects. [ 36 ] The risk is higher in combined phacoemulsification with trabeculectomy. As phacoemulsification itself brings down IOP by ~ 2 mm Hg, Ologen as an adjunctive would suffice to further decrease the IOP to the desired levels, as would be possible with MMC which is significantly more toxic.…”

Neovascularization of angle following trabeculectomy augmented with mitomycin-C

“…[ 31 ] Such effect has not been studied and reported in the eye with the commonly used concentration, duration, and rinsing after MMC application. [ 32 ]…”

Corneal Decompensation Following Bleb Revision With Absolute Alcohol: Clinical Pathological Correlation

“…This finding is consistent with numerous reports of corneal toxicity in humans following exposure to a number of agents, including preservatives, medications, irrigating solutions, and sterilizing agents. 3,4 The severity of the reaction is similar to that of mitomycin C. 5 It is also consistent with reports of corneal decompensation following inadvertent exposure of the corneal endothelium to alcohol in monkeys during perfusion experiments (oral communication, Paul Kaufman, September 2003). Experiments with corneal epithelium have shown that toxicity occurs in cadaver eyes with exposures of 20% ethanol for 45 seconds 6 and in immortalized epithelial cell lines with exposure of 20% ethanol for more than 30 seconds or with 20-second exposures of ethanol concentrations above 25%.…”

Ologen implant versus mitomycin C in combined trabeculectomy and phacoemulsification

“…MMC has been shown to cause have toxic intraocular effects. [ 36 ] The risk is higher in combined phacoemulsification with trabeculectomy. As phacoemulsification itself brings down IOP by ~ 2 mm Hg, Ologen as an adjunctive would suffice to further decrease the IOP to the desired levels, as would be possible with MMC which is significantly more toxic.…”

Neovascularization of angle following trabeculectomy augmented with mitomycin-C

“…[ 31 ] Such effect has not been studied and reported in the eye with the commonly used concentration, duration, and rinsing after MMC application. [ 32 ]…”

Corneal Decompensation Following Bleb Revision With Absolute Alcohol: Clinical Pathological Correlation

“…This finding is consistent with numerous reports of corneal toxicity in humans following exposure to a number of agents, including preservatives, medications, irrigating solutions, and sterilizing agents. 3,4 The severity of the reaction is similar to that of mitomycin C. 5 It is also consistent with reports of corneal decompensation following inadvertent exposure of the corneal endothelium to alcohol in monkeys during perfusion experiments (oral communication, Paul Kaufman, September 2003). Experiments with corneal epithelium have shown that toxicity occurs in cadaver eyes with exposures of 20% ethanol for 45 seconds 6 and in immortalized epithelial cell lines with exposure of 20% ethanol for more than 30 seconds or with 20-second exposures of ethanol concentrations above 25%.…”

Ologen implant versus mitomycin C in combined trabeculectomy and phacoemulsification

“…MMC has been shown to cause have toxic intraocular effects. [ 36 ] The risk is higher in combined phacoemulsification with trabeculectomy. As phacoemulsification itself brings down IOP by ~ 2 mm Hg, Ologen as an adjunctive would suffice to further decrease the IOP to the desired levels, as would be possible with MMC which is significantly more toxic.…”

Neovascularization of angle following trabeculectomy augmented with mitomycin-C

“…[ 31 ] Such effect has not been studied and reported in the eye with the commonly used concentration, duration, and rinsing after MMC application. [ 32 ]…”