2020
DOI: 10.21203/rs.2.23838/v1
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Abstract: BackgroundDiabetes mellitus in elderly represents an exceptional subset in the population vulnerable to cardiovascular events. As aging, diabetes mellitus and hypertension share common pathways, an ideal treatment should possess the ability to counter more than, if not all, the underlying mechanisms. Stem cells emerged as a potential approach for complicated medical problems. We tested here the possible role of trans-differentiated endothelial cells (ECs) in the treatment of diabetes mellitus in old rats.

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Cited by 5 publications
(7 citation statements)
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“…During the aging process, tissues release cytokines such as IL-1β, IL-6, and TNF-α, proteins such CRP, and proinflammatory transcription factors such as the nuclear factor kappa B (NFκB). The circulating inflammatory mediators have been implicated in the pathogenesis and progression of tissue alteration and failure in the elderly [24]. Pro-inflammatory cytokines might induce the formation of reactive oxygen species (ROS) which could trigger an inflammatory response through the activation of transcription factor NFκB [44].…”
Section: Discussionmentioning
confidence: 99%
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“…During the aging process, tissues release cytokines such as IL-1β, IL-6, and TNF-α, proteins such CRP, and proinflammatory transcription factors such as the nuclear factor kappa B (NFκB). The circulating inflammatory mediators have been implicated in the pathogenesis and progression of tissue alteration and failure in the elderly [24]. Pro-inflammatory cytokines might induce the formation of reactive oxygen species (ROS) which could trigger an inflammatory response through the activation of transcription factor NFκB [44].…”
Section: Discussionmentioning
confidence: 99%
“…The administration of resveratrol significantly restored the redox balance. Age-dependent oxidative stress occurs when the production of ROS exceeds the antioxidant defence capacity [24]. ROS promotes lipid peroxidation, oxidation of proteins and nucleic acids, and structural alteration of the membranes resulting in cellular damage [47].…”
Section: Discussionmentioning
confidence: 99%
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“…The trans-differentiated ECs (tdECs) were injected by the tail vein 6 weeks after diabetes verification. The tdECs derived from hW-MSCs could counter the dysfunction of endothelium, inflammation and oxygen-induced stress [87].…”
Section: Other Mesenchymal Stem Cellsmentioning
confidence: 99%
“…RT-PCR assays were performed in duplicate for all target and housekeeping genes using Applied Biosystems 7500 FAST 96-well PCR machine (USA). To evaluate the effects of GSH on CFX-induced AKI, the mRNA expression levels of glutathione peroxidise (GPx), glutathione reductase (GSR) and cytochrome P450-family 4-subfamily F1 (CYP4F1) genes were evaluated by RT-PCR assay as described previously [20][21][22]. Brie y, total RNA was extracted following homogenizing frozen or fresh kidney specimens using TRI reagent (Sigma-Aldrich, UK).…”
Section: Quantitative Rt-pcr (Qrt-pcr)mentioning
confidence: 99%