Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Sitarek, Przemysław; Merecz-Sadowska, Anna; Kowalczyk, Tomasz; Wieczfińska, Joanna; Zajdel, Radosław; Śliwiński, Tomasz

doi:10.3390/ijms21145105

Cited by 32 publications

(21 citation statements)

References 197 publications

(144 reference statements)

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“…The fingerprint analysis of samples showed the presence of large amounts of phenolic acids, catechins and related proanthocyanidins, stilbenes, and flavonoids glycosides ( Figure 1 and Figure 2 ), useful as a raw material for the topical cosmetical preparation [ 43 ]. Their potential therapeutic effect in many skin disorders, including infected wounds and UV-irradiation, is probably related to the synergistic action of these bioactive molecules [ 44 ]. These compounds can inhibit ROS-generating enzymes such as xanthine oxidase and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Identifying a Role of Red and White Wine Extracts in Counteracting Skin Aging: Effects of Antioxidants on Fibroblast Behavior

et al. 2021

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Dermal fibroblasts are the main actor in many proteins’ secretion, including collagen, preserving skin function. Free radicals are involved in skin aging and damages involving different cellular components. The imbalance between reactive oxygen species (ROS) amount and natural antioxidant enzymes negatively affects skin homeostasis. Natural compounds have recently emerged as a potential anti-aging tool in tissue regeneration. In the present paper we evaluated the antioxidant activity of white and red wines, considering their probable use, as raw materials, for the formulation of cosmetic products with anti-aging properties. We studied a method that would allow the removal of the alcoholic fraction of wines and determined their composition by LC-MS analysis. We then tested the possible cytotoxic effects of red and white wines on fibroblasts by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay, and their antioxidant activity by the catalase activity test in stressing conditions. Finally, we evaluated their anti-aging potential through the β-galactosidase colorimetric assay. Our results showed that wine extracts exhibit a remarkable antioxidant and anti-aging activity, especially on cells exposed to a marked stressful event. These properties could suggest their possible application as cosmetical products for skin regeneration.

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Section: Discussionmentioning

confidence: 99%

Identifying a Role of Red and White Wine Extracts in Counteracting Skin Aging: Effects of Antioxidants on Fibroblast Behavior

et al. 2021

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“…Several classes of plant secondary metabolites are known, including phenolics, alkaloids, saponins, terpenes, lipids, and carbohydrates. These have a wide range of biological effects in humans, including antioxidant [ 18 ], anti-inflammatory [ 19 ], anticancer [ 20 ], antibacterial [ 21 ], antiviral, antifungal [ 22 ], antiobesity [ 23 ], antidiabetic, antiosteoporotic, and cardioprotective or neuroprotective [ 24 ] properties.…”

Section: Characteristics and Function Of Phenolic Compounds—crucial Plant Secondary Metabolites With Antioxidative Propertiesmentioning

confidence: 99%

Antioxidant Properties of Plant-Derived Phenolic Compounds and Their Effect on Skin Fibroblast Cells

et al. 2021

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Plants are rich sources of a diverse range of chemicals, many of which have significant metabolic activity. One large group of secondary compounds are the phenolics, which act as inter alia potent reactive oxygen scavengers in cells, including fibroblasts. These common dermis residue cells play a crucial role in the production of extracellular matrix components, such as collagen, and maintaining the integrity of connective tissue. Chronic wounds or skin exposure to UV-irradiation disrupt fibroblast function by the generation of reactive oxygen species, which may damage cell components and modify various signaling pathways. The resulting imbalance may be reversed by the antioxidant activity of plant-derived phenolic compounds. This paper reviews the current state of knowledge on the impact of phenolics on fibroblast functionality under oxidative stress conditions. It examines a range of compounds in extracts from various species, as well as single specific plant-derived compounds. Phenolics are a good candidate for eliminating the causes of skin damage including wounds and aging and acting as skin care agents.

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“…The therapeutic agents originated from plants are as follows: aspirin, codeine, papaverine, colchicine, digoxin and digitoxin, cannabidiol, tetrahydrocannabinol, vinblastine and vincristine, artemisinin, galantamine, apomorphine hydrochloride, tiotropium bromide, paclitaxel, camptothecin and allicin [ 24 ]. Plant-based products possess numerous contributing properties, such as antimicrobial [ 25 ], antiobesity [ 26 ], antioxidant [ 27 ], anti-inflammatory [ 28 ] or anticancer [ 29 ] properties. Moreover, the chemical diversity of natural compounds allows creation of new molecules of plant origin, which also offer several bioactivities [ 30 ].…”

Section: Medicinal Plants With Economic Valuementioning

confidence: 99%

Anti-Inflammatory Activity of Extracts and Pure Compounds Derived from Plants via Modulation of Signaling Pathways, Especially PI3K/AKT in Macrophages

Merecz-Sadowska

Sitarek

Śliwiński

et al. 2020

IJMS

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The plant kingdom is a source of important therapeutic agents. Therefore, in this review, we focus on natural compounds that exhibit efficient anti-inflammatory activity via modulation signaling transduction pathways in macrophage cells. Both extracts and pure chemicals from different species and parts of plants such as leaves, roots, flowers, barks, rhizomes, and seeds rich in secondary metabolites from various groups such as terpenes or polyphenols were included. Selected extracts and phytochemicals control macrophages biology via modulation signaling molecules including NF-κB, MAPKs, AP-1, STAT1, STAT6, IRF-4, IRF-5, PPARγ, KLF4 and especially PI3K/AKT. Macrophages are important immune effector cells that take part in antigen presentation, phagocytosis, and immunomodulation. The M1 and M2 phenotypes are related to the production of pro- and anti-inflammatory agents, respectively. The successful resolution of inflammation mediated by M2, or failed resolution mediated by M1, may lead to tissue repair or chronic inflammation. Chronic inflammation is strictly related to several disorders. Thus, compounds of plant origin targeting inflammatory response may constitute promising therapeutic strategies.

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Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Cited by 32 publications

References 197 publications

Identifying a Role of Red and White Wine Extracts in Counteracting Skin Aging: Effects of Antioxidants on Fibroblast Behavior

Identifying a Role of Red and White Wine Extracts in Counteracting Skin Aging: Effects of Antioxidants on Fibroblast Behavior

Antioxidant Properties of Plant-Derived Phenolic Compounds and Their Effect on Skin Fibroblast Cells

Anti-Inflammatory Activity of Extracts and Pure Compounds Derived from Plants via Modulation of Signaling Pathways, Especially PI3K/AKT in Macrophages

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