Potential role of immune system activation-associated production of neopterin derivatives in humans

Hoffmann, Georg; Wirleitner, Barbara; Fuchs, Dietmar

doi:10.1007/s00011-003-1181-9

Cited by 204 publications

(156 citation statements)

References 92 publications

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“…Bayram et al have also founded that neopterin levels in menopausal women higher than premenopausal women's [16]. It may have resulted from co-morbid diseases such as atherosclerosis, malnutrition or chronic obstructive pulmonary diseases that led to chronic immune activation [12,18]. Melicharova et al has demonstrated that presence of two or more comorbid conditions and older age than 70 years resulting in significantly increased urinary neopterin levels in breast carcinoma patients [19].…”

Section: Discussionmentioning

confidence: 99%

Serum neopterin as a prognostic indicator in patients with breast carcinoma

et al. 2010

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AbstractNeopterin is a useful indicator of the activation state of the cellular immune system, and an elevated level predicts prognosis in different types of tumors. The aim of this study was to evaluate serum neopterin levels if it is viable predictor for prognosis in breast carcinoma patients. Serum neopterin was investigated in 56 breast carcinoma patients, 16 patients with benign breast lesions and 16 healthy women as controls. Neopterin was measured by ELISA (Enzyme-linked immunosorbent assay). The clinicopathological parameters were determined by reviewing both medical charts and pathological records. All patients had been followed-up until September 2009 or death.The mean serum neopterin concentrations were 8.5 ± 5.2 nmol/L in patients with breast carcinoma, 6.5±3.1 nmol/L in patients with benign breast lesion and 8.1 ± 1.9 nmol/L in healthy volunteers (p>0.05). Elevated neopterin levels were significantly correlated with age, elevated serum CRP level, advanced stage and presence of the distant metastases (p<0.05). Overall survival was significantly shorter in patients with a serum neopterin level >10 nmol/L than patients with neopterin <10 nmol/L level (56 months vs. 76 months, p=0.011). Increased preoperative serum neopterin concentrations are associated with a poor prognosis in patients with breast carcinoma.

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Section: Discussionmentioning

confidence: 99%

Serum neopterin as a prognostic indicator in patients with breast carcinoma

et al. 2010

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“…In v//ro-studies provide evidence that neopterin is not only a marker reflecting an activated cellular immune system, but exerts distinct biochemical effects characterizing it as a pro-inflammatory mediator (13). In this context, an increase in serum neopterin concentration at moderate altitude may serve as an indicator for additional Stimulation of the immune system in patients with metabolic Syndrome.…”

Section: Discussionmentioning

confidence: 99%

AMAS (Austrian Moderate Altitude Study)-2000: Effects of Hiking Holidays at Moderate Altitude on Immune System Markers in Persons with Metabolic Syndrome.

Schobersberger¹,

Hoffmann²,

Fries³

et al. 2004

Pteridines

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Recent studies have shown a strong association between indices of inflammation and metabolic Syndrome. Proinflammatory mediators like tumor necrosis factor-a may act as a trigger for insulin insensitivity. Therefore. patients with tnetabolic Syndrome might be at higher risk of insulin resistance when confronted with additional Stimuli of the immune system. These Stimuli are not restricted to thc presence of pathogens but include environmental factors like physical exercise and hypoxemia as well. With respect to these interdependencies, one may assume higher risk for patients with metabolic Syndrome who perform physical exercise in alpine regions. We investigated the effects of a 3-weeks holiday with moderate sporting activities at moderate altitude (1700 m) on the conceiitrations of neopterin, tumor necrosis factor-a, serum soluble 75kD type TNF receptor (sTNF-R75), and interleukin-6 in vacationers with metabolic Syndrome. Only serum neopterin and sTNF-R75 concentrations transiently increased during the stay at moderate altitude compared to pre-altitude levels (P<0.05). Interestingly, after return to 500 m sea-level neopterin concentrations dropped beyond baseline concentrations (p<0.05). However, the variations in neopterin concentrations might not be of clinical relevance since they did not exceed the threshold indicating significant activation of the cellular immune system. We conclude that a 3-week sojourn at moderate altitude including individually adapted physical exercise does not represent accumulated risk factors in subjects with metabolic Syndrome.

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“…The above-mentioned spleen cells were washed with α-MEM once, and cell pellets were suspended in 10 mL of 0.86% NH 4 Cl for 5 min at 4°C for lysis of erythrocytes. The spleen cells were then washed twice with α-MEM and mononuclear cells of the BM were obtained.…”

Section: Isolation Of Lineage-negative Spleen Cells [Lin (-) Spleen Cmentioning

confidence: 99%

“…An increased neopterin production is observed following infection by viruses, bacteria and parasites (3). Because neopterin level in body fluid reflects immune responses in vivo, neopterin is regarded as a sensitive marker of the activation of the cellular immune system in humans as well as a factor for prognosis and its indicator biomarker (3,4). However, there is evidence that neopterin is not only a marker of the activity of the immune system, but it also exerts distinct biological effects (3,4).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Effect of Neopterin on Splenic Mast Cell Development in Senescence Accelerated Mice (SAM)

Harada

Tsuboi

Yuda³

et al. 2007

Pteridines

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Neopterin is produced by monocytes and is a useful biomarker of inflammatory responses. We found that neopterin enhances granulopoiesis, but suppresses B-lymphopoiesis triggered by the positive-and negative regulations of cytokines produced by stromal cells in mice. Furthermore, neopterin suppressed the colony formation of mast cell progenitor (CFU-mast) from bone marrow cells in in vitro culture system. In this study, neopterin was also found to regulate the proliferation and differentiation of splenic CFU-mast in vitro as observed in that from bone marrow, which was confirmed in the mouse model of senescent stromal-cell impairment (SCI). In non-SCI mice (=less senescent stage of SCI mice), neopterin also decreased the number of colonies of interleukin-3 (IL-3)-dependent mast-cell progenitor cells (CFU-mast) from unfractionated spleen cells, but not that from the lineage-negative (fractionated) spleen cell population without stromal cells in a semisolid in vitro culture system. In contrast, in a case of SCI mice, the treatment with neopterin did not decrease the number of colonies of IL-3-dependent mast-cell progenitor cells (CFU-mast) from unfractionated spleen cells. These results suggest that, firstly, neopterin decrease the number of colonies of IL-3-dependent CFU-mast by stimulating splenic stromal cells, and secondly, such neopterin function becomes declined during senescence because of an impaired stromalcell function.

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Potential role of immune system activation-associated production of neopterin derivatives in humans

Cited by 204 publications

References 92 publications

Serum neopterin as a prognostic indicator in patients with breast carcinoma

Serum neopterin as a prognostic indicator in patients with breast carcinoma

AMAS (Austrian Moderate Altitude Study)-2000: Effects of Hiking Holidays at Moderate Altitude on Immune System Markers in Persons with Metabolic Syndrome.

In Vitro Effect of Neopterin on Splenic Mast Cell Development in Senescence Accelerated Mice (SAM)

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