Potential oncogenic role of human cytomegalovirus and histone deacetylase 3 expression in colorectal cancer

Abstract

Aims: This study was conducted to investigate whether there is a link between HDAC3 expression and clinical characteristics in colorectal cancer (CRC) patients and to detect the oncopotenial role of HCMV in colorectal cancer (CRC). Material and methods: 30 samples of formalin fixed-Paraffin embedded archival tissues were collected from patient suffering of CRC , In addition to 10 samples of free cancer tissue for determine of expression of HDAC3 and CMV by using immunohistochemistry. Results: HDAC3 expression by Immunohisto-chemical (IHC) staining was found in 19 samples (63. 3%) of CRC. While There is no expression of CMV in all samples of CRC and control groups. Conclusion: This study proved HDAC3 expression pattern in CRC, and the findings support HDAC3 as a supplementary marker to known histopathological diagnostic components; it could potentially be used in prognosis and targeted therapy. We also found that there is no correlation of the CMV infection and CRC as a pro-tumorigenic factor.