Integrated industrial hubs (IIHs) are the major cause of water pollution in India. This chapter reveals the issues of industrialization and its causes and consequences to the environment in total and water in particular. Environmental pollution is a worldwide problem, now receiving worldwide attention. The majority of the solid wastes and wastewaters are released into the soil and water bodies. Fundamental contributors of the surface and groundwater contamination are the results of different manufacturing units, for example, textile, metal, dying chemicals, pesticides, cement, petrochemical, fertilizers, energy, sugar processing, construction, leather, steel, engineering, food processing, mining and others. Water and human health are correlated wherein one affects the other, and the magnitude of the problem is such that its solution invites an integrated approach. Thus, proper treatment and disposal of IIH wastewater should be done to mitigate its environmental impacts. Therefore, this book chapter deals with the characteristics and potential effects of integrated industrial hubs (IIHs) on surface and groundwater quality in India. The information provided suggests implementing effective measures to mitigate their wastewater disposal impacts.