Potential of Stem Cells in the Treatment of Nervous System Disorders

Seghatoleslam, Masoumeh; Hosseini, Mahmoud

doi:10.18869/acadpub.shefa.3.1.99

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…118 118 ، 9 ‫مزانشــیمی‬ ‫بنیــادی‬ ‫های‬ ‫ســلول‬ ، 8 ‫جنینــی‬ ‫بنیــادی‬ ‫ســاز‬ ‫پیش‬ ‫های‬ ‫ســلول‬ ، 10 ‫عصبــی‬ ‫بنیــادی‬ ‫های‬ ‫ســلول‬ ‫پرتــوان‬ ‫بنیــادی‬ ‫های‬ ‫ســلول‬ ، 11 ‫بزرگســاالن‬ ‫چندتوانــی‬ ‫های‬ ‫ســلول‬ ‫و‬ 13 ‫اندوتلیــال‬ ‫ســاز‬ ‫پیش‬ ‫های‬ ‫ســلول‬ ، 12 ‫القايــی‬ ‫ارائــه‬ ‫بــه‬ ‫ادامــه‬ ‫در‬ ‫شــوند.لذا،‬ ‫می‬ 14 Spinal cord injury 2 Traumatic brain injury 3 Hyperbaric Oxygen 4 Blood brain barrier 5 Exogenous stem cells 6 Schwann cells 7 Olfactory Ensheathing cells 8 Embryonic stem cells 9 Mesenchymal stem cells 10 Neural Stem Cells 11 Multipotent Adult Progenitor Cells 12 Induced Pluripotent Stem Cells 13 Endothelial progenitor cells 14 Embryonal carcinoma cells 15 Self-renewal 16…”

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Stem Cells and their Applications for the Treatment of Injuries to the Central Nervous System

Hassanpour-Ezatti

Nikookar

2021

Shefaye Khatam

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The most common causes of brain and spinal cord injuries are accidents, falls, sports injuries, and trauma, which can lead to sensory and motor function deficits. Enormous efforts have been made to use stem cells to repair and prevent the development of complications caused by damage to the central nervous system. The main challenge in this field is to select the right stem cells to replace the lost nerve cells and prevent processes that disrupt the function of stem cells. In this review article, current information on various stem cells used in the treatment of damage to the nervous system, the possible mechanisms of their functions have been discussed. Furthermore, advantages and disadvantages of stem cell therapy are described based on the findings of basic and clinical studies. The high cost of stem cell therapy and unwanted side effects are major challenges in using stem cell therapy to repair the nervous system. Thus, more investigations are required to optimize cell therapy approaches in clinical settings. Conclusion: The existence of different types of stem cells with diverse capabilities and solving existing problems can increase the hope of using of stem cell therapy to treat damage to the nervous system.m

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Stem Cells and their Applications for the Treatment of Injuries to the Central Nervous System

Hassanpour-Ezatti

Nikookar

2021

Shefaye Khatam

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Roles of stem cells in the treatment of Parkinson's disease

Ebrahimikia

Darabi

Rajaei

2018

J Qazvin Univ Med Sci

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Stem cells are undifferentiated cells with the ability to divide and differentiate into distinct cell types. The source of these cells is from embryos and adults, that each cell has its own specific characteristics. For nearly decades, experimental studies have been conducted to use these types of cells to treat various diseases. Parkinson's disease is one of the most common neurodegenerative diseases, resulting in a deficiency of dopaminergic neurons. Therefore, we study the role of stem cell therapies in the treatment of Parkinson's disease. Initially, 73 relevant articles selected from valid databases such as ISC, SID, Google Scholar and PubMed and the role of each type of stem cell in the treatment of Parkinson's disease was collected. Stem cells can be used in experimental studies regard to the unique characteristics and using different laboratory agents for any particular type of cells. Stem cells can provide an unlimited source of dopaminergic neurons for transplantation and improve motor behavior and symptoms of Parkinson's disease. Study and comparison of different types of stem cells refer to the more effective role of neural and umbilical stem cells in treating Parkinson's disease.

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