Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment

Wong, Chun Y; Al‐Salami, Hani; Dass, Crispin R.

doi:10.1016/j.jconrel.2017.09.003

Cited by 197 publications

(139 citation statements)

References 210 publications

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“…Their ionic properties and hydrophilicity have made them targets for use in organic electronics, catalysis, battery electrolytes, surfactants, drug‐delivery, and antifouling coatings, among other applications . ZI‐incorporated polymers (polyZIs) have also been investigated as novel materials for chromatography, drug‐delivery, self‐assembled microstructures, and battery electrolytes …”

Section: Introductionmentioning

confidence: 99%

Ion transport mechanisms in salt‐doped polymerized zwitterionic electrolytes

Keith

Ganesan

2020

Journal of Polymer Science

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Polyzwitterions (polyZIs), macromolecules with repeating ampholytic monomers, are a novel class of materials with attractive properties for battery electrolytes. In this study, we probe the ion transport characteristics and underlying mechanisms in two salt‐doped (Li+‐TFSI−) polyZIs of similar composition with contrasting zwitterion (ZI) ionic organization: pendant monomers organized via backbone‐anion‐cation (B‐ZI−‐ZI+, Motif B) and backbone‐cation‐anion (B‐ZI+‐ZI−, Motif C). Within both Motifs B and C, the counterion of the pendant‐end ZI moiety shows higher mobility. Similarly, when comparing Li+ or TFSI− across motifs, it is seen that the respective pendant‐end counterion possesses higher mobility than its backbone‐adjacent counterpart. Furthermore, when comparing counterions to same‐position ZI moieties, TFSI− is seen to possess higher mobility than Li+ in each case, a result rationalized by invoking the lower interaction strength between the TFSI− and ZI+. Analysis of ion‐transport mechanisms demonstrate that the mobility of countercharges to the pendant‐end ZI moiety correlates with the ion‐association relaxation timescale, similar to ideas noted in polymerized ionic liquids in past studies. However, the mobility of countercharges to the backbone‐adjacent ZI moiety is shown to be correlated with a cage relaxation time, which incorporates the combined effects of frustrated motion due to the presence of the polymer backbone and pendant‐end ZI moiety and the higher mobility in a population of lightly ZI‐coordinated ions. © 2020 Wiley Periodicals, Inc. J. Polym. Sci. 2020, 58, 578–588

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Section: Introductionmentioning

confidence: 99%

Ion transport mechanisms in salt‐doped polymerized zwitterionic electrolytes

Keith

Ganesan

2020

Journal of Polymer Science

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“…[38][39][40][41] The side amino and hydroxyl groups of CS could be modified with diverse array of ligands, functional groups and moieties. However, CS is not soluble in aqueous solution at neutral pH, which is a big obstacle for its application in protein delivery.…”

Section: Strategies For Intracellular Protein Deliverymentioning

confidence: 99%

“…To enhance its solubility in aqueous solution, various CS derivatives have been designed by chemical modifications including alkylation, thiolation, carboxylation, quaternization, PEGylation and acylation. [38][39][40][41] The side amino and hydroxyl groups of CS could be modified with diverse array of ligands, functional groups and moieties. On the one hand, this kind of modification could enhance its aqueous solubility in different pH solution; on the other hand, it could also improve stability, mucoadhesivity, and TJs abilities by coupling with the targeted moieties.…”

Section: Strategies For Intracellular Protein Deliverymentioning

confidence: 99%

Rational Design of Nanocarriers for Intracellular Protein Delivery

et al. 2019

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Protein/antibody therapeutics have exhibited the advantages of high specificity and activity even at an extremely low concentration compared to small molecule drugs. However, they are accompanied by unfavorable physicochemical properties such as fragile tertiary structure, large molecular size, and poor penetration of the membrane, and thus the clinical use of protein drugs is hindered by inefficient delivery of proteins into the host cells. To overcome the challenges associated with protein therapeutics and enhance their biopharmaceutical applications, various protein‐loaded nanocarriers with desired functions, such as lipid nanocapsules, polymeric nanoparticles, inorganic nanoparticles, and peptides, are developed. In this review, the different strategies for intracellular delivery of proteins are comprehensively summarized. Their designed routes, mechanisms of action, and potential therapeutics in live cells or in vivo are discussed in detail. Furthermore, the perspective on the new generation of delivery systems toward the emerging area of protein‐based therapeutics is presented as well.

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“…The filtrate was collected and again filtered through another membrane of 0.05µ pore size (polycarbonate membrane filter) and the residue on the membrane was washed thrice with distilled water and was retrieved from the filter unit. The nanoparticulate suspension was then transferred to glass vials and was prefreezed to -80 ºC, the prefreezed samples were then freeze dried using (Subzero lab instruments, Chennai) at -80 ºC for 24 h. The freeze dried nanoparticles were collected and was stored in the refrigerator 28,29,30 .…”

Section: Preparation Of Imatinib Mesylate Loaded Solidmentioning

confidence: 99%

Untitled

2018

IJPSR

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For a formulation scientist, the delivery of therapeutic agents to the diseased organ has been a challenging problem. It is expected to improve the therapeutic index and reduce side effects of a drug by good delivery strategy to diseased organ. The objective of this investigation is to evaluate the targeting potential of solid lipid nanoparticle (SLN) formulation of imatinib mesylate to the lymphatic system using response surface methodology of design of experiment. Box-Behnken DOE was constructed using imatinib mesylate, compritol 888 ATO (X1) and pluronic F68 (X2) as independent factors and particle size (Y1) and entrapment efficiency (Y2) as dependant factors. The SLN formulation was prepared by hot homogenization followed by ultrasonication. Prepared SLN were analyzed by FTIR, DSC, DLS, PXRD and SEM. The optimized particle size and entrapment efficiency of the imatinib mesylate loaded solid lipid nanoparticle was found to be 190 nm and 62.5% respectively, which are sufficient to reach lymphatic system. FTIR revealed no interaction between imatinib mesylate and compritol 888 ATO. Compritol 888 ATO retained its crystalline nature in the imatinib mesylate loaded SLN formulation revealed by DSC study. The results showed that pharmacokinetic parameters such as area under the whole blood concentration-time curve, Cmax, Tmax were significantly different (P<0.05) compared with standard imatinib mesylate oral suspension and the targeting efficiency of both imatinib mesylate loaded SLN and the standard suspension at the mesenteric lymph node significantly increased (P<0.05).

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Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment

Cited by 197 publications

References 210 publications

Ion transport mechanisms in salt‐doped polymerized zwitterionic electrolytes

Ion transport mechanisms in salt‐doped polymerized zwitterionic electrolytes

Rational Design of Nanocarriers for Intracellular Protein Delivery

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