Potential of butyrate to influence food intake in mice and men

Fluitman, Kristina S.; Wijdeveld, Madelief; Nieuwdorp, Max; IJzerman, Richard G.

doi:10.1136/gutjnl-2017-315543

Cited by 29 publications

(21 citation statements)

References 10 publications

(11 reference statements)

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“…Propionate and butyrate could also stimulate the generation of peptide YY (PYY) and glucagon‐like peptide‐1 (GLP‐1) in the colon, which could further influence the of neuropeptide Y (NPY) expression in hypothalamus, the appetite‐regulating hormone . Butyrate was reported to enhance the secretion of appetite suppressing hormones such as leptin from adipose tissues . Moreover, SCFAs were also found to be involved in regulating energy metabolism by enhancing lipolysis in the adipose tissue .…”

Section: Introductionmentioning

confidence: 99%

“…[31] Butyrate was reported to enhance the secretion of appetite suppressing hormones such as leptin from adipose tissues. [35] Moreover, SCFAs were also found to be involved in regulating energy metabolism by enhancing lipolysis in the adipose tissue. [36] Therefore, the SCFAs might play pivotal mediating roles leading to the beneficial effects of MOS.…”

Section: Introductionmentioning

confidence: 99%

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Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western‐Diet‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production

Yan

Shi

et al. 2019

Molecular Nutrition Food Res

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Scope Obesity is associated with gut microbiome dysbiosis. Mannose oligosaccharide (MOS) has been reported to be a potential prebiotic. The present study is aimed to determine the effects of MOS on western‐diet‐induced obesity and to uncover the mediating roles of the gut microbiota and microbial metabolites. Methods and results Three‐month‐old male ICR mice are fed with a high‐fat and high‐fructose diet for 8 weeks. The diet‐induced obese mice are then orally administrated with MOS (100 and 200 mg kg–1 d–1) for 4 weeks. MOS significantly reduces bodyweight gain, insulin resistance, fatty liver, and inflammatory responses in obese mice. MOS also stimulates lipolysis and inhibits lipogenesis in the adipose tissues. Moreover, MOS restructures the gut microbiome by enhancing the abundance of Bifidobacterium and Lactobacillus in obese mice. The microbial metabolite SCFAs are also increased in the feces and serum. Correlation analysis indicates that the appetite suppression and lipid‐lowering effects of MOS are highly correlated with the butyrate levels. Conclusion MOS suppresses the appetite, which results in less lipid deposition. The lower appetite is likely due to an altered gut microbiome and elevated SCFAs production. MOS may be a potential nutraceutical used in body weight management and gut health improvement.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western‐Diet‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production

Yan

Shi

et al. 2019

Molecular Nutrition Food Res

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“…, HF-A4. glucagon-like peptide-1 or peptide YY, thus inhibiting the initiation of a next meal (31,32) . Satiety can also be linked to a period of elimination of metabolic waste resulting from hepatic oxidation and N metabolism (33) .…”

Section: Discussionmentioning

confidence: 99%

Feeding behaviour and pre-prandial status affect post-prandial plasma energy metabolites and insulin kinetics in growing pigs fed diets differing in fibre concentration

et al. 2019

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Variations in feeding behaviour between animals result from individual variations in their metabolism as affected by diet composition. The study aimed to link the within-day dynamics of voluntary feed intake and those of blood metabolites and insulin in growing pigs havingad libitumaccess to feed and receiving diets differing in dietary fibre levels and aleurone supplementation. A total of forty pigs (body weight: 35 kg) had access to diets providedad libitum, which differed by fibre content (13 or 18 % neutral-detergent fibre) and aleurone supplementation (0, 2 or 4 g/kg). Feeding behaviour was individually recorded for 1 week. The kinetic of plasma metabolites and insulin was followed for 1 h after a voluntary test meal. Dietary fibre level did not affect the daily feed intake but increased meal size and meal duration. Aleurone supplementation (4 g/kg) decreased the daily feed intake and number of meals. Dietary fibre level only decreased insulin concentration measured 15 min after meal beginning. Aleurone supplementation (4 g/kg) decreased glycaemia in the first hour after the meal and insulinaemia 15 min after the meal. Free access to feed led to high variability in pre-prandial metabolites and insulin concentrations, resulting in different test meal size irrespective of diet composition. Animals were then spread over different profiles combining feeding behaviour and fasted status to explain different profiles of regulation of feed intake. Plasma metabolites and insulin kinetics were affected by diet composition but also by animal characteristics. Individual variability should be considered when diet composition is used to modulate feeding behaviour.

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“…Indeed, vagal afferent chemoreceptors potentially sense SCFAs or gut hormones such as GLP-1 to presumably dominate the acervulus cerebri and eventually decrease appetite. 106 Acute oral administration of butyrate restricts the activity of neuropeptide Yexpressing orexigenic neurons and eventually drives satiety and diminished appetite. 107 Elevated levels of acetate elicit anorectic effects in the hypothalamus, possibly via inhibiting 5-AMPactivated kinase.…”

Section: Scfa-mediated Modulation Of Host Metabolismmentioning

confidence: 99%

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Zhang

Tang

Chen

et al. 2019

Sig Transduct Target Ther

184

151

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The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology. Remarkable progress in large-scale sequencing and mass spectrometry has increased our understanding of the influence of the microbiome and/or its metabolites on the onset and progression of extraintestinal cancers and the efficacy of cancer immunotherapy. Given the plasticity in microbial composition and function, microbial-based therapeutic interventions, including dietary modulation, prebiotics, and probiotics, as well as fecal microbial transplantation, potentially permit the development of novel strategies for cancer therapy to improve clinical outcomes. Herein, we summarize the latest evidence on the involvement of the gut microbiome in host immunity and metabolism, the effects of the microbiome on extraintestinal cancers and the immune response, and strategies to modulate the gut microbiome, and we discuss ongoing studies and future areas of research that deserve focused research efforts.

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Potential of butyrate to influence food intake in mice and men

Cited by 29 publications

References 10 publications

Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western‐Diet‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production

Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western‐Diet‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production

Feeding behaviour and pre-prandial status affect post-prandial plasma energy metabolites and insulin kinetics in growing pigs fed diets differing in fibre concentration

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

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