volume 55, issue 6, P1613-1629 1990
DOI: 10.1135/cccc19901613
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Abstract: The title compounds VI-XXIII were prepared by heating ethyl (2-oxo-1-pyrrolidinyl)acetate (II) with a series of N-monosubstituted piperazines. The propionamides XXVI and XXX were obtained by reactions of the acid chlorides IV and XXXIII with 3-(1-piperazinyl)propionamide. Compounds VI (V⁄FB-13 763) and VIII (V⁄FB-14 745) proved more active than piracetam (I) by their antiamnesic effects in rats, by antagonizing the brain-damaging effects of cycloheximide in infantile rats, and by their potentiation of the effe…

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