Potential Impact of Quercetin and Idebenone against Immuno- inflammatory and Oxidative Renal Damage Induced in Rats by Titanium Dioxide Nanoparticles Toxicity

Al-Rasheed, Nouf M.; Faddah, L. M.; Mohamed, Azza M.; Baky, Nayira A. Abdel; Al-Rasheed, Nawal M.; Mohammad, Raeesa A.

doi:10.5650/jos.62.961

Cited by 38 publications

(40 citation statements)

References 40 publications

(40 reference statements)

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“…Furthermore, quercetin restored the reduced activities of GSH-related enzymatic antioxidants. Quercetin is recognized to have a strong scavenging activity of oxygen radicals and protection against lipid and protein oxidation which has been primarily attributed to its flavonoid fraction [10,13,38,39].…”

Section: Discussionmentioning

confidence: 99%

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Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species

et al. 2015

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Section: Discussionmentioning

confidence: 99%

“…It has been reported to exhibit cell protection owing to its antioxidant, antinociceptive, and anti-inflammatory actions [10,11]. Nevertheless, quercetin is still a subject of various re-assessment studies concerning its hepatic and renal protective effect due to the comparative little information available.…”

Section: Introductionmentioning

confidence: 99%

Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species

et al. 2015

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“…Our recently published study showed its antiapoptotic, antioxidative, and antiaging effects on primary optic nerve head astrocytes in terms of glaucoma treatment [19]. Rather few studies evaluated other tissues, such as kidney, and also showed promising antioxidative effects [51]. AMD is an important oxidative stress-related eye disease whose treatment options are still not exhausted [3].…”

Section: Discussionmentioning

confidence: 99%

Idebenone Prevents Oxidative Stress, Cell Death and Senescence of Retinal Pigment Epithelium Cells by Stabilizing BAX/Bcl-2 Ratio

et al. 2015

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Purpose: Age-related macular degeneration (AMD) is one of the leading causes of blindness. Degeneration of the retinal pigment epithelium (RPE) is pathognomonic for the disease, and oxidative stress plays an important role in the pathogenesis of this disease. This study investigates potential antiapoptotic and cytoprotective effects of idebenone on cultured RPE cells (ARPE-19) under conditions of oxidative stress. Methods: ARPE-19 cells were treated with 1-100 µM idebenone. Cell viability (MTT assay), induction of intracellular reactive oxygen species (ROS) and histone-associated DNA fragments in mono- and oligonucleosomes, expression of proapoptotic BAX and antiapoptotic Bcl-2 as well as senescence-associated β-galactosidase (SA-β-Gal) activity were investigated under exposure to hydrogen peroxide (H₂O₂). Results: Idebenone concentrations from 1 to 20 µM showed no toxic effects on ARPE-19 cells. When cells were treated with H₂O₂, pretreatment with 5, 7.5, 10, and 20 µM idebenone led to a significant increase in the viability of ARPE-19 cells. In addition, idebenone pretreatment significantly attenuated the induction of SA-β-Gal and intracellular ROS as well as the amount of histone-associated DNA fragments after treatment with H₂O₂. The reduction of proapoptotic BAX and the elevation of antiapoptotic Bcl-2 under idebenone show that this process is rather mediated by inhibiting H₂O₂-induced apoptosis, not necrosis. Conclusion: In this study, idebenone increased survival of ARPE-19 cells and reduced cell death, senescence, and oxidative stress by stabilizing the BAX/Bcl-2 ratio.

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“…Quercetin could scavenge free radicals and inhibit xanthine oxidase and lipid peroxidation. It protects against oxidative damage in renal tubular cells and renal tissues [24]. Our study showed that quercetin prevented the unfavorable changes of serum SOD and MDA in the CKD model.…”

Section: Discussionmentioning

confidence: 66%

Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats

Chang

Cui

Wang

et al. 2017

BioMed Research International

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Background This study investigated whether quercetin could alleviate vascular calcification in experimental chronic renal failure rats induced by adenine. Methods 32 adult male Wistar rats were randomly divided into 4 groups fed normal diet, normal diet with quercetin supplementation (25 mg/kg·BW/d), 0.75% adenine diet, or adenine diet with quercetin supplementation. All rats were sacrificed after 6 weeks of intervention. Serum renal functions biomarkers and oxidative stress biomarkers were measured and status of vascular calcification in aorta was assessed. Furthermore, the induced nitric oxide synthase (iNOS)/p38 mitogen activated protein kinase (p38MAPK) pathway was determined to explore the potential mechanism. Results Adenine successfully induced renal failure and vascular calcification in rat model. Quercetin supplementation reversed unfavorable changes of phosphorous, uric acid (UA) and creatinine levels, malonaldehyde (MDA) content, and superoxide dismutase (SOD) activity in serum and the increases of calcium and alkaline phosphatase (ALP) activity in the aorta (P < 0.05) and attenuated calcification and calcium accumulation in the medial layer of vasculature in histopathology. Western blot analysis showed that iNOS/p38MAPK pathway was normalized by the quercetin supplementation. Conclusions Quercetin exerted a protective effect on vascular calcification in adenine-induced chronic renal failure rats, possibly through the modulation of oxidative stress and iNOs/p38MAPK pathway.

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Potential Impact of Quercetin and Idebenone against Immuno- inflammatory and Oxidative Renal Damage Induced in Rats by Titanium Dioxide Nanoparticles Toxicity

Cited by 38 publications

References 40 publications

Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species

Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species

Idebenone Prevents Oxidative Stress, Cell Death and Senescence of Retinal Pigment Epithelium Cells by Stabilizing BAX/Bcl-2 Ratio

Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats

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