Potential impact of Helicobacter pylori and metabolic syndrome-related non-alcoholic fatty liver disease on cardio-cerebrovascular disease

Kountouras, Jannis; Papaefthymiou, Apostolis; Polyzos, Stergios A.; Liatsos, Christos; Tzitiridou‐Chatzopoulou, Maria; Chatzopoulos, Dimitrios; Vardaka, Elisabeth; Gialambrinou, Dimitra; Kotronis, Georgios; Doulberis, Michael

doi:10.1016/j.metabol.2022.155276

Cited by 8 publications

(10 citation statements)

References 12 publications

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“…26 Furthermore, patients with H. pylori infection and NAFLD may have an increased risk of cardio-cerebrovascular disease. 31 H. pylori infection has also been associated with higher serum fetuin A levels. 2,32 Fetuin A is a glycoprotein, which transports free fatty acids and may lead to increased fat deposition in hepatocytes.…”

Section: H Pylori Infection As a Risk Factor For Nafldmentioning

confidence: 99%

Impact of Helicobacter pylori Infection on the Pathogenesis and Management of Nonalcoholic Fatty Liver Disease

Mavilia-Scranton¹,

Wu²,

Dharan³

2023

J Clin Transl Hepatol

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Section: H Pylori Infection As a Risk Factor For Nafldmentioning

confidence: 99%

Impact of Helicobacter pylori Infection on the Pathogenesis and Management of Nonalcoholic Fatty Liver Disease

Mavilia-Scranton¹,

Wu²,

Dharan³

2023

J Clin Transl Hepatol

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“…In this regard, Helicobacter pylori ( H. pylori ) infection consists one of the most common chronic infections since it affects more than 50% of the world population [ 22 ]. Emerging evidence supports its involvement in the pathophysiology of many neurodegenerative disorders [ 21 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, H. pylori is also related to metabolic syndrome (MetS)-systemic pathologies such as cardio-cerebrovascular and neurodegenerative diseases, the end outcomes of MetS [ 22 , 62 ].…”

Section: Introductionmentioning

confidence: 99%

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Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration

et al. 2023

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Helicobacter pylori infection consists a high global burden affecting more than 50% of the world’s population. It is implicated, beyond substantiated local gastric pathologies, i.e., peptic ulcers and gastric cancer, in the pathophysiology of several neurodegenerative disorders, mainly by inducing hyperhomocysteinemia-related brain cortical thinning (BCT). BCT has been advocated as a possible biomarker associated with neurodegenerative central nervous system disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and/or glaucoma, termed as “ocular Alzheimer’s disease”. According to the infection hypothesis in relation to neurodegeneration, Helicobacter pylori as non-commensal gut microbiome has been advocated as trigger and/or mediator of neurodegenerative diseases, such as the development of Alzheimer’s disease. Among others, Helicobacter pylori-related inflammatory mediators, defensins, autophagy, vitamin D, dietary factors, role of probiotics, and some pathogenetic considerations including relevant involved genes are discussed within this opinion article. In conclusion, by controlling the impact of Helicobacter pylori-related hyperhomocysteinemia on neurodegenerative disorders might offer benefits, and additional research is warranted to clarify this crucial topic currently representing a major worldwide burden.

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“…Nonalcoholic fatty liver disease (NAFLD), recently renamed as metabolic (dysfunction)-associated fatty liver disease (MAFLD) [ 1 ], has become one of the most significant liver diseases. The prevalence of MAFLD/NAFLD is increasing worldwide, together with the pandemic of obesity and other metabolic syndrome (MetS) parameters, affecting at least 25% of the adult population globally [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Innate immunity and nonalcoholic fatty liver disease

Kountouras

Kazakos

Kyrailidi

et al. 2023

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Potential impact of Helicobacter pylori and metabolic syndrome-related non-alcoholic fatty liver disease on cardio-cerebrovascular disease

Cited by 8 publications

References 12 publications

Impact of Helicobacter pylori Infection on the Pathogenesis and Management of Nonalcoholic Fatty Liver Disease

Impact of Helicobacter pylori Infection on the Pathogenesis and Management of Nonalcoholic Fatty Liver Disease

Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration

Innate immunity and nonalcoholic fatty liver disease

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