JAMA
 2006
DOI: 10.1001/jama.296.20.2480
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Potential for Genetics to Promote Public Health

Chris Carlsten
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Wylie Burke2
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Cited by 52 publications

(24 citation statements)
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“…Yet, her weighing of risks versus benefits reflects debates on the public health impact of personalized risk factors for addiction (Carlsten and Burke 2006; Merikangas and Risch 2003). For smoking, the best public health advice, regardless of individual predispositions, is to not smoke.…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Yet, her weighing of risks versus benefits reflects debates on the public health impact of personalized risk factors for addiction (Carlsten and Burke 2006; Merikangas and Risch 2003). For smoking, the best public health advice, regardless of individual predispositions, is to not smoke.…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Further, there is a need for genetic information to be rigorously evaluated, with demonstrated and cost effective health benefits, before it is used in a clinical setting (Burke & Psaty, 2007). From a cost-benefit standpoint, many scholars have questioned whether preventative screening or personalized genetic information for addiction will ever be more effective than more traditional approaches (Carlsten & Burke, 2006; W. D. Hall et al, 2008; Merikangas & Risch, 2003), like taking a simple family history (Gartner, Barendregt, & Hall, 2009).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Researchers have raised many concerns about the psychological effects of genetic testing related to smoking [24]. Three of these concerns were brought up by respondents in this study: (1) the fear of fatalistic thinking about smoking initiation or cessation, (2) the idea that a negative test could provide permission to experiment with smoking, and (3) the fear of genetic discrimination.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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