Potential effects of brevetoxins and toxic elements on various health variables in Kemp's ridley (Lepidochelys kempii) and green (Chelonia mydas) sea turtles after a red tide bloom event

Perrault, Justin R.; Stacy, Nicole I.; Lehner, Andreas F.; Mott, Cody R.; Hirsch, Steffen; Gorham, Jonathan C.; Buchweitz, John P.; Bresette, Michael J.; Walsh, Catherine J.

doi:10.1016/j.scitotenv.2017.06.149

Cited by 49 publications

(57 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1), suggesting that any correlations observed with toxic elements are a result of past exposure and not due to changes in food intake or from tissue mobilization during the nesting season. These results add to the existing literature regarding accumulation and the potential effects of toxic elements on marine turtle health (Day et al, 2007;Innis et al, 2008;Komoroske et al, 2011;Register, 2011;Camacho et al, 2013;Villa et al, 2017;Ley-Quiñónez et al, 2017;Perrault et al, 2017).…”

Section: Discussionsupporting

confidence: 58%

“…Furthermore, just four of these studies examined correlations with toxic elements and health parameters (loggerheads: Day et al, 2007;Camacho et al, 2013; green turtles, Chelonia mydas: Komoroske et al, 2011;Kemps' ridley, Lepidochelys kempii: Innis et al, 2008). Since the publication of Finlayson et al (2016), three additional studies examined correlations between hematological and plasma biochemistry analytes and toxic elements in marine turtles (green turtles: Villa et al, 2016;Perrault et al, 2017;loggerheads: Ley-Quiñónez et al, 2017;Kemp's ridleys: Perrault et al, 2017). These seven studies documented correlations between toxic elements and indicators of disease (e.g., fibropapillomatosis), body condition, organ function, immune function, ion regulation, oxidative stress, and overall health; however, these results are often not discussed due to confounding factors (e.g., size, season, sex) or due to lack of understanding of reptilian toxicology ( Innis et al, 2008;Komoroske et al, 2011;Labrada-Martagόn et al, 2011;Camacho et al, 2013;).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Toxic elements and associations with hematology, plasma biochemistry, and protein electrophoresis in nesting loggerhead sea turtles (Caretta caretta) from Casey Key, Florida

Perrault

Stacy

Lehner

et al. 2017

Environmental Pollution

Self Cite

View full text Add to dashboard Cite

Toxic elements (arsenic, cadmium, lead, mercury, selenium, thallium) are a group of contaminants that are known to elicit developmental, reproductive, general health, and immune system effects in reptiles, even at low concentrations. Reptiles, including marine turtles, are susceptible to accumulation of toxic elements due to their long life span, low metabolic rate, and highly efficient conversion of prey into biomass. The objectives of this study were to (1) document concentrations of arsenic, cadmium, lead, mercury, selenium, and thallium in whole blood and keratin from nesting loggerhead sea turtles (Caretta caretta) from Casey Key, Florida and document correlations thereof and (2) correlate whole blood toxic element concentrations to various hematological and plasma biochemistry analytes. Baselines for various hematological and plasma analytes and toxic elements in whole blood and keratin (i.e., scute) in nesting loggerheads are documented. Various correlations between the toxic elements and hematological and plasma biochemistry analytes were identified; however, the most intriguing were negative correlations between arsenic, cadmium, lead, and selenium with and α- and γ-globulins. Although various extrinsic and intrinsic variables such as dietary and feeding changes in nesting loggerheads need to be considered, this finding may suggest a link to altered humoral immunity. This study documents a suite of health variables of nesting loggerheads in correlation to contaminants and identifies the potential of toxic elements to impact the overall health of nesting turtles, thus presenting important implications for the conservation and management of this species.

show abstract

Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Toxic elements and associations with hematology, plasma biochemistry, and protein electrophoresis in nesting loggerhead sea turtles (Caretta caretta) from Casey Key, Florida

Perrault

Stacy

Lehner

et al. 2017

Environmental Pollution

Self Cite

View full text Add to dashboard Cite

show abstract

“…Concentrations for most were higher than seen in Kemp's ridleys found actively swimming and feeding during a K. brevis bloom in Florida (Perrault et al 2014(Perrault et al , 2017; >1.00−33.8 ng ml −1 measured in blood plasma). Brevetoxicosis was determined to be the cause of death for 10 of these turtles due to detection of PbTx in tissues and digesta and the finding of no significant injuries or signs of illness during necropsy.…”

Section: Discussionmentioning

confidence: 66%

Brevetoxin exposure in sea turtles in south Texas (USA) during Karenia brevis red tide

Walker¹,

Shaver²,

Stacy³

et al. 2018

Dis. Aquat. Org.

View full text Add to dashboard Cite

“…In the case of fibropapillomatosis, UV exposure could be directly involved in oncogenic transformation, as is the case for human skin cancers, or alternatively could be acting through indirect mechanisms. For instance, increased UV could contribute to immunosuppression resulting in reduced control of ChHV5 infections 95 , increased frequency of algal bloom events, which have been correlated with fibropapillomatosis occurrence 5,42–44,97 , or UV radiation, which can alter the chemical composition of contaminants in inshore waters into carcinogenic forms 98,99 . Future research is required to determine whether UV exposure is causally linked to fibropapillomatosis tumor development, and if so, via which mechanism.…”

Section: Discussionmentioning

confidence: 99%

Sea turtle fibropapilloma tumors share genomic drivers and therapeutic vulnerabilities with human cancers

et al. 2018

View full text Add to dashboard Cite

Wildlife populations are under intense anthropogenic pressures, with the geographic range of many species shrinking, dramatic reductions in population numbers and undisturbed habitats, and biodiversity loss. It is postulated that we are in the midst of a sixth (Anthropocene) mass extinction event, the first to be induced by human activity. Further, threatening vulnerable species is the increased rate of emerging diseases, another consequence of anthropogenic activities. Innovative approaches are required to help maintain healthy populations until the chronic underlying causes of these issues can be addressed. Fibropapillomatosis in sea turtles is one such wildlife disease. Here, we applied precision-medicine-based approaches to profile fibropapillomatosis tumors to better understand their biology, identify novel therapeutics, and gain insights into viral and environmental triggers for fibropapillomatosis. We show that fibropapillomatosis tumors share genetic vulnerabilities with human cancer types, revealing that they are amenable to treatment with human anti-cancer therapeutics.

show abstract

Potential effects of brevetoxins and toxic elements on various health variables in Kemp's ridley (Lepidochelys kempii) and green (Chelonia mydas) sea turtles after a red tide bloom event

Cited by 49 publications

References 88 publications

Toxic elements and associations with hematology, plasma biochemistry, and protein electrophoresis in nesting loggerhead sea turtles (Caretta caretta) from Casey Key, Florida

Toxic elements and associations with hematology, plasma biochemistry, and protein electrophoresis in nesting loggerhead sea turtles (Caretta caretta) from Casey Key, Florida

Brevetoxin exposure in sea turtles in south Texas (USA) during Karenia brevis red tide

Sea turtle fibropapilloma tumors share genomic drivers and therapeutic vulnerabilities with human cancers

Contact Info

Product

Resources

About