Potential effects of bisphenol A on diabetes mellitus and its chronic complications: A narrative review

Jiang, Wei; Ding, Kaixi; Huang, Wenjie; Feng, Xin; Lei, Ming; Yue, Rensong

doi:10.1016/j.heliyon.2023.e16340

Cited by 10 publications

(4 citation statements)

References 82 publications

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“…Drug prediction revealed two compounds that were most closely targeted towards NEBL gene and biomarkers, bisphenol A (BPA) and Valproic Acid. BPA demonstrates an association with low-grade albuminuria, a manifestation characteristic of the initial phases of DN 34 . Moreover, ndings certi ed that valproic acid mitigated the diabetes-induced upregulation of complement C5a receptors, concurrently diminishing indicators of cellular senescence and the senescence-associated secretory phenotype.…”

Section: Discussionmentioning

confidence: 98%

Machine learning-based identification of biomarkers associated with NEBL in diabetic nephropathy

Tao,

Xu,

2024

Preprint

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Patients with diabetes had a significantly increased risk of cardiovascular disease by reporter, and the nebulette (NEBL) gene were closely related with cardiovascular disease. However, the impact of the NEBL gene on diabetic nephropathy (DN) and the underlying molecular mechanisms, have yet to be conclusively validated. Therefore, this study aims to mine NEBL related biomarkers in DN by bioinformatics analysis. A total of 157 differentially expressed genes (DEGs) associated with DN and NEBL gene were excavated, and they were associated with biological processes of mesonephric development and AGE-RAGE signaling pathway in diabetic complications. Besides, totally 19 candidate genes were screened by correlation and expression analyses, among which, MPP5, TGFBR3, PCMTD2 and C1orf21 related to NEBL were deemed as biomarkers via Support Vector Machine-Recursive Feature Elimination (SVM-RFE), Boruta and least absolute shrinkage and selection operator (LASSO) algorithms, the ability of NEBL and biomarkers to distinguish DN from controls was accurate. Immunoinfiltration certified that the contents of 12 differential immune cells were significantly increased in DN group. Then, the gene set enrichment analysis (GSEA) revealed that NEBL and biomarkers were observably enriched in ribosome, intestinal immune network for immunoglobulin A (IgA) production and so on. Finally, drug-gene network revealed bisphenol A and Valproic Acid might be pivotal drugs regulating the expression of NEBL and biomarkers.In this sutudy, totally four biomarkers (MPP5, TGFBR3, PCMTD2 and C1orf21) related to NEBL were screened by bioinformatic analysis, providing a novel reference for effective clinical diagnosis and treatment of DN.

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Section: Discussionmentioning

confidence: 98%

Machine learning-based identification of biomarkers associated with NEBL in diabetic nephropathy

Tao,

Xu,

2024

Preprint

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“…BPA is ubiquitously present in the environment, air, water, soil, animal feed, wildlife, and humans [ 141 , 142 , 143 ]. While the role of direct BPA exposure in the development of diabetes mellitus and obesity has been explored extensively [ 144 , 145 ], there is a gap in the research on the prenatal effect of BPA on liver pathologies. This study was performed to address causal relationships between prenatal BPA and liver steatosis, as human studies can only point to association and not causality.…”

Section: Discussionmentioning

confidence: 99%

Developmental Programming: Impact of Prenatal Exposure to Bisphenol A on Senescence and Circadian Mediators in the Liver of Sheep

Motta,

Thangaraj,

Padmanabhan

2023

Toxics

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Prenatal exposure to endocrine disruptors such as bisphenol A (BPA) plays a critical role in the developmental programming of liver dysfunction that is characteristic of nonalcoholic fatty liver disease (NAFLD). Circadian and aging processes have been implicated in the pathogenesis of NAFLD. We hypothesized that the prenatal BPA-induced fatty-liver phenotype of female sheep is associated with premature hepatic senescence and disruption in circadian clock genes. The expression of circadian rhythm and aging-associated genes, along with other markers of senescence such as telomere length, mitochondrial DNA copy number, and lipofuscin accumulation, were evaluated in the liver tissue of control and prenatal BPA groups. Prenatal BPA exposure significantly elevated the expression of aging-associated genes GLB1 and CISD2 and induced large magnitude differences in the expression of other aging genes—APOE, HGF, KLOTHO, and the clock genes PER2 and CLOCK—in the liver; the other senescence markers remained unaffected. Prenatal BPA-programmed aging-related transcriptional changes in the liver may contribute to pathological changes in liver function, elucidating the involvement of aging genes in the pathogenesis of liver steatosis.

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“…BPA is considered to be an endocrine disruptor [22,25]. It is also considered by several authors to be the cause of numerous diseases [19,26,27]. In recent years, BPA has been the subject of numerous studies worldwide.…”

Section: Of 17mentioning

confidence: 99%

Transfer of Bisphenol A and Trace Metals from Plastic Packaging to Mineral Water in Ouagadougou, Burkina Faso

Sawadogo,

Konaté,

Konaté

et al. 2023

IJERPH

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The consumption of packaged water is growing rapidly in both urban and rural centres in Burkina Faso. Bisphenol A (BPA) and trace metals are among the compounds used in the manufacture of plastic packaging, and their presence in water can pose a health risk to consumers due to their alleged toxicity. Therefore, this study explores the transfer of these compounds from plastic packaging to mineral water in Sudano-Sahelian climatic conditions. Ten samples of packaged sachet water commercialised in Ouagadougou were studied. An absence of BPA in the borehole water used to produce packaged water has been shown. The transfer of BPA into mineral water increases with storage temperature. The BPA that appears in packaged water degrades over time. BPA concentrations ranged from 0 to 0.38 mg/L after two weeks of storage, 0 to 0.8 mg/L after four weeks of storage and 0 to 0.35 mg/L after 8 weeks of storage. Analysis of the trace metals showed steadily increasing concentrations from the second to the sixth weeks, with concentrations ranging from 0 to 9.7 µg/L for cadmium and from 0 to 0.13 mg/L for iron in the sachet water samples.

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Potential effects of bisphenol A on diabetes mellitus and its chronic complications: A narrative review

Cited by 10 publications

References 82 publications

Machine learning-based identification of biomarkers associated with NEBL in diabetic nephropathy

Machine learning-based identification of biomarkers associated with NEBL in diabetic nephropathy

Developmental Programming: Impact of Prenatal Exposure to Bisphenol A on Senescence and Circadian Mediators in the Liver of Sheep

Transfer of Bisphenol A and Trace Metals from Plastic Packaging to Mineral Water in Ouagadougou, Burkina Faso

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