Potential diabetic cardiomyopathy therapies targeting pyroptosis: A mini review

Abstract

Pyroptosis is primarily considered a pro-inflammatory class of caspase-1- and gasdermin D (GSDMD)-dependent programmed cell death. Inflammasome activation promotes the maturation and release of interleukin (IL)-1β and IL-18, cleavage of GSDMD, and development of pyroptosis. Recent studies have reported that NLRP3 inflammasome activation-mediated pyroptosis aggravates the formation and development of diabetes cardiomyopathy (DCM). These studies provide theoretical mechanisms for exploring a novel approach to treat DCM-associated cardiac dysfunction. Accordingly, this review aims to summarize studies that investigated possible DCM therapies targeting pyroptosis and elucidate the molecular mechanisms underlying NLRP3 inflammasome-mediated pyroptosis, and its potential association with the pathogenesis of DCM. This review may serve as a basis for the development of potential pharmacological agents as novel and effective treatments for managing and treating DCM.

Exogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes

“…Furthermore, formation of pores in the cell membrane, and the release of inflammatory factors cause cell swelling, membrane rupture, and pyroptosis [15,[20][21][22]. Pyroptosis involves in development of various diseases such as diabetic cardiomyopathy, myocardial infarction, and diabetic renal endothelial cell damage [23][24][25]. Furthermore, suppressing pyroptosis by sodium-glucose co-transporter-2 (SGLT-2) inhibitors, proprotein convertase subtilisin/Kexin type 9 (PCSK9) inhibitor, or sodium butyrate is considered to have possibility as therapeutics for those diseases which are associated with pyroptosis [23][24][25].…”

Hydrogen sulfide plays an important role by regulating endoplasmic reticulum stress in myocardial diseases

“…2 Hydrogen sulfide plays an important role by regulating endoplasmic reticulum stress in diabetes cardiomyopathy 2.1 Exogenous hydrogen sulfide improves diabetes cardiomyopathy through reactive oxygen species (ROS)/endoplasmic reticulum stress/autophagy/apoptosis pathway Diabetes cardiomyopathy (DCM) is a pathophysiological condition caused by diabetes, which induces heart failure without hypertension, coronary artery diseases and valvular heart diseases (Dillmann, 2019;Lorenzo-Almorós et al, 2022;Nakamura et al, 2022). Although there have been many studies on DCM in recent years, its pathogenesis still needs to be further clarified (Zhao et al, 2022c;Jia et al, 2022). The evidence indicates that DCM is related to oxidative stress and apoptosis (Thandavarayan et al, 2011;Kumar et al, 2013).…”

“…Diabetes cardiomyopathy (DCM) is a pathophysiological condition caused by diabetes, which induces heart failure without hypertension, coronary artery diseases and valvular heart diseases ( Dillmann, 2019 ; Lorenzo-Almorós et al, 2022 ; Nakamura et al, 2022 ). Although there have been many studies on DCM in recent years, its pathogenesis still needs to be further clarified ( Zhao et al, 2022c ; Jia et al, 2022 ). The evidence indicates that DCM is related to oxidative stress and apoptosis ( Thandavarayan et al, 2011 ; Kumar et al, 2013 ).…”