Potential dermatological application on Asian plants

Ariffin, Nor Hazwani Mohd; Hasham, Rosnani

doi:10.1007/s12257-015-0750-4

Cited by 15 publications

(17 citation statements)

References 145 publications

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“…MMP-9, a type IV collagenase, may show a major role during cell growth, inflammation, and angiogenesis [15]. VCO contains lauric acid, which has antimicrobial, anti-viral, anti-fungal and antibacterial properties [8]. VCO and HVCO contain bioactive components which play a role in wound healing [15].…”

Section: Discussionmentioning

confidence: 99%

“…Coconut oil is the most saturated oil compose of medium-chain fatty acids, including capric (7%), lauric (49%), myristic (18%), palmitic (9%), stearic (2%), and small percentages of unsaturated fatty acids that including oleic (6%) and linoleic acids (2%) [7]. VCO isolated from mature coconut fruit and processed at low temperature without chemical refining, bleaching or deodorising, and which does not lead to the conversion of the nature of the oil [8]. VCO contains more biological active constituent such as tocopherols, sterols, polyphenols, and squalene [9].…”

Section: Introductionmentioning

confidence: 99%

“…VCO contains more biological active constituent such as tocopherols, sterols, polyphenols, and squalene [9]. VCO contains lauric acid, which has antimicrobial, anti-viral, anti-fungal and antibacterial properties [8]. Partial hydrolysis of VCO (HVCO) using lipase from Rhizomucor miehei which is active on sn-1, 3 positions in triglyceride molecule resulted in free fatty acids and 2-monoglyceride mainly a mixture of lauric acids and more active antibacterial monolaurin [10], [11], [12].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Coconut Oil to Increase Expression of MMP-9, PDGF-BB, and TGF-β1 in NIH-3T3 Cell Line

Meliala

Silalahi

Yuandani

et al. 2019

Open Access Maced J Med Sci

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AIM: The objective of the study was to evaluate protein expression in NIH 3T3 cells that are treated with virgin coconut oil (VCO) and hydrolysed of virgin coconut oil (HVCO) in vitro. METHODS: Coconut oil used in this study was virgin coconut oil (VCO) and VCO hydrolysed by Rhizomucor miehei (HVCO). NIH 3T3 cells (5x105 cells/well) were seeded in nine wells and incubated for overnight, then divided into three groups. Each group consisted of three wells. Group one without treatment, group two added VCO, and group three added HVCO and then incubated for overnight. One well in each group was added MMP-9, PDGF-BB, and TGF-β1 and incubated one hour. Finally, expressions of MMP-9, PDGF-BB, and TGF-β1 were detected using immunocytochemistry method. RESULTS: The results of the study showed that VCO and HVCO increased protein expressions of MMP-9, PDGF-BB, and TGF-β1. Percentage of MMP-9 expressions treated by VCO increased from 2.89 ± 0.07 to 28.16 ± 0.34, PDGF-BB from 28.11 ± 0.13 to 48.53 ± 0.49, and TGF-β1 from 4.19 ± 0.08 to 18.41 ± 0.54. Percentage of MMP-9 expressions treated by HVCO increased from 2.89 ± 0.07 to 55.40 ± 0.94, PDGF-BB from 28.11 ± 0.13 to 61.65 ± 0.42, and TGF-β1 from 4.19 ± 0.08 to 36.35 ± 0.67. CONCLUSION: VCO and HVCO increase the expression of MMP-9, PDGF-BB, dan TGF-β1 in NIH3T3 cells and therefore, coconut oil active in the wound healing process. HVCO is more than active than VCO.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of Coconut Oil to Increase Expression of MMP-9, PDGF-BB, and TGF-β1 in NIH-3T3 Cell Line

Meliala

Silalahi

Yuandani

et al. 2019

Open Access Maced J Med Sci

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“…Healthy skin can shield the body from environmental influences, including physical factors such as mechanical damage, thermal injury and radiation, chemical factors such as allergens, biological factors such as microbes, viruses, and others. 1 Wounds are affected by natural physiological processes and functions. 2 Wounds can occur as a result of physical, chemical or biological trauma.…”

Section: Backgroundsmentioning

confidence: 99%

Differences of Reeda Scale in Wound Incision Abdomen Post Obstetrics / Gynaecology Laparotomy with Topical Virgin Coconut Oil (VCO) and Without Topical Virgin Coconut Oil (VCO)

Wahdini

Ferry

Syukur

2021

AOJ

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Introduction : Wounds are defects of normal anatomical structures and functions. Injuries can occur because of physical, chemical, or biological trauma. Wound healing is a complex process involving many cells, cytokines, growth factors, proteases, and extracellular matrix (ECM) that work together to restore the integrity of the injured tissue. Virgin Coconut Oil is an oil saturated with medium-chain fatty acids (MCFA), one of which is lauric acid. Based on our research, VCO has wound healing properties. Research conducted in vivo on rabbits and rats experienced an increase in collagen, fibroblast proliferation, and neovascularization which influenced accelerating wound healing.Objective : This study aims to determine the difference in the mean REEDA scale in abdominal incision wounds after obstetric / gynecology laparotomy with topical VCO and those without topical VCO.Material and methods : This study is an experimental research design with a randomized clinical trial that was conducted on 36 people divided into 2 groups (treatment and control). Post-obstetric / gynecology laparotomy patients were subjected to topical VCO application on the incision wound and the REEDA scale was calculated at 24, 48, and 72 hours post-surgery. Statistical analysis is using the Mann-Whitney test.Results : Age mean of the respondents in the treatment group was 32.28 ± 10.42 years old, while the untreated group was 30.5 ± 6.54 years old. The mean REEDA scale for abdominal incision wounds applied topical VCO at 24 hours was 3.17 ± 1.04, at 48 hours was 2.11 ± 1.08, and at 72 hours was 1.39 ± 0.85. The mean REEDA scale for abdominal incision wounds that were not treated with topical VCO at 24 hours was 3.83 ± 0.99, at 48 hours was 3.11 ± 1.37 and at 72 hours was 2.72 ± 1.41. The findings of the experimental analyses showed that there was no association with the use of topical VCO in surgical wounds on a 24-hour REEDA scale (p>0.05), there was a relationship between the use of topical VCO in surgical wounds on a 48-hour and 72-hour REEDA scale (p<0.05). In the care group, the mean REEDA scale decreased by 33.4 % from 24 to 48 hours and 34.1 % from 48 to 72 hours.Conclusion : There is a relationship with the use of topical VCO in post-abdominal incision wounds post obstetrics/gynaecology laparotomy with REEDA scale 48 hours and 72 hours post-surgery. The mean REEDA scale decreased by over 24 to 48 hours and 48 to 72 hours in the treatment group (who administered topical VCO in postoperative incision wounds).Keywords: VCO, REEDA scale, Wound healing

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“…The use of herbal drugs to treat a broad spectrum of diseases and/or to modify non-pathological states [ 1 , 2 , 3 , 4 ] has increased worldwide. It is known that the secondary metabolites of plants have therapeutic effects; many have been used in the treatment of different diseases, such as obesity [ 5 ] and brain [ 6 ] and skin diseases [ 7 ] as well as in the treatment of non-pathological states, such as aging [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and Its Topical Applications: A Review

Macedo

Santos

Militão

et al. 2020

Plants

116

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Topical application is an important administration route for drugs requiring local action on the skin, thereby avoiding their systemic absorption and adverse side effects. Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.), popularly known as rosemary, is an aromatic plant with needle-like leaves belonging to the Lamiaceae family. Rosemary has therapeutic properties and has been used in the folk medicine, pharmaceutical, and cosmetics industries, mainly for its antioxidant and anti-inflammatory properties, which are attributed to the presence of carnosol/carnosic and ursolic acids. The therapeutic use of rosemary has been explored for the treatment of inflammatory diseases; however, other uses have been studied, such as wound healing and skin cancer and mycoses treatments, among others. Besides it therapeutic uses, rosemary has potential applications in cosmetic formulations and in the treatment of pathological and non-pathological conditions, such as cellulite, alopecia, ultraviolet damage, and aging. This review aims to critically discuss the topical applications of rosemary found in the literature while also offering relevant information for the development of topical formulations of its bioactive compounds.

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Potential dermatological application on Asian plants

Cited by 15 publications

References 145 publications

The Role of Coconut Oil to Increase Expression of MMP-9, PDGF-BB, and TGF-β1 in NIH-3T3 Cell Line

The Role of Coconut Oil to Increase Expression of MMP-9, PDGF-BB, and TGF-β1 in NIH-3T3 Cell Line

Differences of Reeda Scale in Wound Incision Abdomen Post Obstetrics / Gynaecology Laparotomy with Topical Virgin Coconut Oil (VCO) and Without Topical Virgin Coconut Oil (VCO)

Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and Its Topical Applications: A Review

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