“…[11][12][13] Such analyses have highlighted that changes in risk factors, including diet, can have relatively quick effects on disease trends, contrary to popular belief, and may guide policy makers in the prioritization of risk factors and policies. 10,13 In this issue of Circulation, Ezzati and colleagues 14 perform a novel, population-level analysis across 199 countries for 4 metabolic risk factors (body mass index [BMI], fasting plasma glucose, systolic blood pressure, and serum total cholesterol) in relation to the degree of social (by urbanization and Western diet) and economic (assessed by gross domestic product) development between 1980 and 2008. At the global and cross-country levels, research, including the GBD study 8,9 and prior data from Ezzati and colleagues, has generally demonstrated overall increasing levels of burden of diabetes mellitus, obesity, and hypertension but with significant variations across risk factors and country-level income.…”