Potential Biomedical Applications of Chitosan – and Chitosan‐Based Nanomaterials

Singh, Gulshan; Manohar, Murli; Arya, Suresh Kumar; Siddiqui, Waseem Ahmad; Stenström, Thor Axel

doi:10.1002/9781119364849.ch14

Cited by 5 publications

(1 citation statement)

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“…Numerous studies have shown that chitosan and chitin can be used in a variety of applications in tissue engineering (Yilgor et al., 2009 ; Liu et al., 2016 ; Pangon et al., 2016 ; Islam et al., 2017 ; Ahsan et al., 2018 ). They can be designed into a variety of structures such as gels, membranes nanofibers, nanoparticle and sponges (Singh et al., 2017 ; Smirnova et al., 2019 ; Zubillaga et al., 2020 ). In combination with properties such as its good biocompatibility, biodegradability, nontoxic, anti-inflammatory, adhesion, antibacterial and nerve protection, chitosan can be made into a suitable candidate for growth factors delivery (Rajam et al., 2011 ).…”

Section: Applications Of Natural Polysaccharides In Tissue Engineerinmentioning

confidence: 99%

Engineered biomaterial strategies for controlling growth factors in tissue engineering

et al. 2020

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Growth factors are multi-functional signaling molecules that coordinate multi-stage process of wound healing. During wound healing, growth factors are transmitted to wound environment in a positive and physiologically related way, therefore, there is a broad prospect for studying the mediated healing process through growth factors. However, growth factors (GFs) themselves have disadvantages of instability, short life, rapid inactivation of physiological conditions, low safety and easy degradation, which hinder the clinical use of GFs. Rapid development of delivery strategies for GFs has been trying to solve the instability and insecurity of GFs. Particularly, in recent years, GFs delivered by scaffolds based on biomaterials have become a hotspot in this filed. This review introduces various delivery strategies for growth factors based on new biodegradable materials, especially polysaccharides, which could provide guidance for the development of the delivery strategies for growth factors in clinic.

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