Potential benefits of using chitosan and silk fibroin topical hydrogel for managing wound healing and coagulation

Narayana, Soumya; Nasrine, Arfa; Ahmed, Mohammed Gulzar; Sultana, Rokeya; Gowda, B.H. Jaswanth; Surya, Suprith; Almuqbil, Mansour; Asdaq, Syed Mohammed Basheeruddin; Alshehri, Sultan; Hussain, Salman

doi:10.1016/j.jsps.2023.01.013

Cited by 19 publications

(5 citation statements)

References 38 publications

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“…Hence, the sterility test was passed by the N-HG and N-SFB-HG formulations. Similar results were reported from a study conducted by Narayana et al, 2023 . Both N-HG and N-SFB-HGs and gel base formulations exhibited no erythema, edema, or allergies upon application on rats ( Fig.…”

Section: Discussionsupporting

confidence: 91%

“…Outstanding biocompatibility, excellent ability to get disintegrated, incredible mechanical strength, and minimal immunogenic capabilities are all characteristics of silk fibroin (SFB). As a result, it has been extensively employed in applications for tissue engineering and regenerative medicine ( Narayana et al, 2023 , Sixma and Van Den Berg, 1984 , McDonald et al, 2007 ). Its application in skin regeneration processes, hemostatic qualities, low inflammatory potential, permeability to oxygen, and water vapor have all been well explored ( Minoura et al, 1990 , Santin et al, 1999 , Lu et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neem (Azadirachta Indica) and silk fibroin associated hydrogel: Boon for wound healing treatment regimen

Nasrine,

Narayana,

Gulzar Ahmed

et al. 2023

Saudi Pharmaceutical Journal

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Neem (Azadirachta Indica) and silk fibroin associated hydrogel: Boon for wound healing treatment regimen

Nasrine,

Narayana,

Gulzar Ahmed

et al. 2023

Saudi Pharmaceutical Journal

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“…The increase in shear rate from 30 to 150 rpm had shown a slight decrease in the viscosity from 140 to 123 cP for the 7% PVA hydrogel forming solution (Supplementary Fig. 5 ), which confirmed the non-Newtonian flow with slight shear-thinning property suitable for polymeric cross-linking application 62 .…”

Section: Methodssupporting

confidence: 57%

Polymer based dual drug delivery system for targeted treatment of fluoroquinolone resistant Staphylococcus aureus mediated infections

Thamilselvan

David

Sajeevan

et al. 2023

Sci Rep

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The present study attempts to treat S. aureus-induced soft skin infections using a combinatorial therapy with an antibiotic, Ciprofloxacin (CIP), and an efflux pump inhibitor 5-Nitro-2-(3-phenylpropoxy) pyridine (5-NPPP) through a smart hydrogel delivery system. The study aims to reduce the increasing rates of infections and antimicrobial resistance; therefore, an efflux pump inhibitor molecule is synthesized and delivered along with an antibiotic to re-sensitize the pathogen towards antibiotics and treat the infections. CIP-loaded polyvinyl alcohol (PVA) hydrogels at varying concentrations were fabricated and optimized by a chemical cross-linking process, which exhibited sustained drug release for 5 days. The compound 5-NPPP loaded hydrogels provided linear drug release for 2 days, necessitating the need for the development of polymeric nanoparticles to alter the release drug pattern. 5-NPPP loaded Eudragit RSPO nanoparticles were prepared by modified nanoprecipitation—solvent evaporation method, which showed optimum average particle size of 230–280 nm with > 90% drug entrapment efficiency. The 5-NPPP polymeric nanoparticles loaded PVA hydrogels were fabricated to provide a predetermined sustained release of the compound to provide a synergistic effect. The selected 7% PVA hydrogels loaded with the dual drugs were evaluated using Balb/c mice models induced with S. aureus soft skin infections. The results of in vivo studies were evidence that the dual drugs loaded hydrogels were non-toxic and reduced the bacterial load causing re-sensitization towards antibiotics, which could initiate re-epithelization. The research concluded that the PVA hydrogels loaded with CIP and 5-NPPP nanoparticles could be an ideal and promising drug delivery system for treating S. aureus-induced skin infections.

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“…In order to evaluate the potential role played by SF in controlling the mechanical properties of previously established Alg-Gel hydrogels for cardiovascular applications [3], we first generated hybrid hydrogels containing 1% and 2% SF. We decided to test these specific SF concentrations based on previous studies [5,8,18,29,33,34].…”

Section: Hydrogel Pore Size Decreases With Increased Sf Concentration...mentioning

confidence: 99%

“…In its regenerated form, SF molecules interact through non-covalent bonds such as hydrogen bonding, between the αhelices and β-sheets (as reported in supplementary figure 1) [1,16]. Alternatively, SF can be added to other formulations to have better control over their mechanical properties and degradation rates [17,18], which can create new hydrogen bonding and electrostatic interactions. For instance, sodium Alg and SF blend through intermolecular hydrogen bonds, which occur between the carboxyl group (COO-) of Alg and the amide group of SF (-NH 2 ), the amide group (both the C=O and -NH 2 ) of SF and -OH molecules in Alg polymer.…”

Section: Introductionmentioning

confidence: 99%

Silk fibroin increases the elasticity of alginate-gelatin hydrogels and regulates cardiac cell contractile function in cardiac bioinks

Vettori,

Tran,

Mahmodi

et al. 2024

Biofabrication

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Silk fibroin (SF) is a natural protein extracted from Bombyx mori silkworm thread. From its common use in the textile industry, it emerged as a biomaterial with promising biochemical and mechanical properties for applications in the field of tissue engineering and regenerative medicine. In this study, we evaluate for the first time the effects of SF on cardiac bioink formulations containing cardiac spheroids. First, we evaluate if the SF addition plays a role in the structural and elastic properties of hydrogels containing alginate (Alg) and gelatin (Gel). Then, we test the printability and durability of bioprinted SF-containing hydrogels. Finally, we evaluate whether the addition of SF controls cell viability and function of cardiac spheroids in Alg-Gel hydrogels. Our findings show that the addition of 1% (w/v) SF to Alg-Gel hydrogels makes them more elastic without affecting cell viability. However, fractional shortening (FS%) of cardiac spheroids in SF-Alg-Gel hydrogels increases without affecting their contraction frequency, suggesting an improvement in contractile function in the 3D cultures. Altogether, our findings support a promising pathway to bioengineer bioinks containing SF for cardiac applications, with the ability to control mechanical and cellular features in cardiac bioinks.

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Potential benefits of using chitosan and silk fibroin topical hydrogel for managing wound healing and coagulation

Cited by 19 publications

References 38 publications

Neem (Azadirachta Indica) and silk fibroin associated hydrogel: Boon for wound healing treatment regimen

Neem (Azadirachta Indica) and silk fibroin associated hydrogel: Boon for wound healing treatment regimen

Polymer based dual drug delivery system for targeted treatment of fluoroquinolone resistant Staphylococcus aureus mediated infections

Silk fibroin increases the elasticity of alginate-gelatin hydrogels and regulates cardiac cell contractile function in cardiac bioinks

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