Potential applications of three-dimensional structure of silk fibroin/poly(ester-urethane) urea nanofibrous scaffold in heart valve tissue engineering

Du, Juan; Zhu, Tonghe; Yu, Haiyue; Zhu, Jingjing; Sun, Changbing; Wang, Jincheng; Chen, Sihao; Wang, Jihu; Guo, Xuran

doi:10.1016/j.apsusc.2018.03.077

Cited by 47 publications

(48 citation statements)

References 46 publications

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“…They reported that the scaffolds were at least 20 times stronger than the native valves and had nearly three times more stiffness than native valves. Similar results were obtained in the study of Du et al [ 150 ], who used a 3D structure scaffold composed of silk fibroin and nanofibrous poly(ester urethane) urea for heart valve tissue engineering. The authors reported that their composite scaffolds significantly supported seeded human umbilical vein endothelial cell growth, suggesting promising potential of the biopolymeric scaffolds for future development and the regeneration of heart valves.…”

Section: Biopolymers-based Aerogels In Tissue Engineering For Therapeutic Applicationssupporting

confidence: 88%

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

et al. 2021

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The global transplantation market size was valued at USD 8.4 billion in 2020 and is expected to grow at a compound annual growth rate of 11.5% over the forecast period. The increasing demand for tissue transplantation has inspired researchers to find alternative approaches for making artificial tissues and organs function. The unique physicochemical and biological properties of biopolymers and the attractive structural characteristics of aerogels such as extremely high porosity, ultra low-density, and high surface area make combining these materials of great interest in tissue scaffolding and regenerative medicine applications. Numerous biopolymer aerogel scaffolds have been used to regenerate skin, cartilage, bone, and even heart valves and blood vessels by growing desired cells together with the growth factor in tissue engineering scaffolds. This review focuses on the principle of tissue engineering and regenerative medicine and the role of biopolymer aerogel scaffolds in this field, going through the properties and the desirable characteristics of biopolymers and biopolymer tissue scaffolds in tissue engineering applications. The recent advances of using biopolymer aerogel scaffolds in the regeneration of skin, cartilage, bone, and heart valves are also discussed in the present review. Finally, we highlight the main challenges of biopolymer-based scaffolds and the prospects of using these materials in regenerative medicine.

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Section: Biopolymers-based Aerogels In Tissue Engineering For Therapeutic Applicationssupporting

confidence: 88%

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

et al. 2021

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“…Silk fibroin obtained from the Bombyx mori silkworm is one of the most commonly used biomaterials due to its availability and low cost [ 29 , 79 ]. It has been shown to exhibit excellent biocompatibility, bioactivity, biodegradability, tunability, mechanical stability, and low immunogenicity, allowing silk-based fibers to be used to create tissue engineering scaffolds that allow for bone [ 82 , 83 , 84 , 85 ], cartilage [ 86 ], heart valve [ 87 ], and nerve [ 88 ] regeneration. The oxygen and water vapor permeability of silk also encourages its use in wound healing [ 25 , 89 ].…”

Section: Protein Materialsmentioning

confidence: 99%

“…Due to its mechanical strength, silk is an ideal protein for tissue regeneration. Recently, Du et al [ 87 ] also used silk fibroin to produce nanofibrous scaffolds for heart valve tissue engineering, but combined the natural polymer with poly(ester-urethane) (PEUU) to improve the fracture resistance of the scaffold. These scaffolds were created by combining the two polymers in hexafluoroisopropanol and following the electrospinning technique previously highlighted.…”

Section: Applications Of Protein-based Nanofibers In Tissue Regenementioning

confidence: 99%

Protein-Based Fiber Materials in Medicine: A Review

et al. 2018

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Fibrous materials have garnered much interest in the field of biomedical engineering due to their high surface-area-to-volume ratio, porosity, and tunability. Specifically, in the field of tissue engineering, fiber meshes have been used to create biomimetic nanostructures that allow for cell attachment, migration, and proliferation, to promote tissue regeneration and wound healing, as well as controllable drug delivery. In addition to the properties of conventional, synthetic polymer fibers, fibers made from natural polymers, such as proteins, can exhibit enhanced biocompatibility, bioactivity, and biodegradability. Of these proteins, keratin, collagen, silk, elastin, zein, and soy are some the most common used in fiber fabrication. The specific capabilities of these materials have been shown to vary based on their physical properties, as well as their fabrication method. To date, such fabrication methods include electrospinning, wet/dry jet spinning, dry spinning, centrifugal spinning, solution blowing, self-assembly, phase separation, and drawing. This review serves to provide a basic knowledge of these commonly utilized proteins and methods, as well as the fabricated fibers’ applications in biomedical research.

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“…Then they prepared silk fibroin/PEUU composite scaffold by electrospinning. Although PEUU might slightly reduce the hydrophilicity of silk fibroin scaffolds, it could enhance the mechanical properties and cell proliferation of the scaffold 76 …”

Section: Synthetic Polymer‐based Composite Scaffoldmentioning

confidence: 99%

Biodegradable synthetic polymeric composite scaffold‐based tissue engineered heart valve with minimally invasive transcatheter implantation

Long

et al. 2020

Polymers for Advanced Techs

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Prosthetic heart valve replacement is the main treatment for valvular heart disease, but the existing artificial valves (mechanical or biological valve) have inherent disadvantages. Patients with mechanical valves require lifelong anticoagulation because of the high risk of thromboembolism, while the durability of biological valve is poor, which easily leads to calcification or lobular degeneration. Besides, they all lack the abilities of self‐repair and growth which are very important for adolescent patients with valvular heart disease. To overcome these shortcomings, the researchers developed tissue engineered heart valves (TEHV) with self‐repairing and remodeling capabilities, low immunogenicity, and great durability. The preparation of three‐dimensional porous scaffolds is the key step in the success of TEHV. Because of their easy processing, active chemical properties, great mechanical properties and controllable degradation rate, synthetic biodegradable polymers are widely used in the preparation of TEHV scaffolds. This review summarizes the types, properties and process techniques of biodegradable synthetic polymers, such as polycaprolactone, polyglycolic acid, polylactic acid, and polyhydroxyalkanoates currently used to prepare the TEHV scaffolds. This review also focuses on the composite methods and performance of synthetic polymer‐based composite scaffolds. The prospects and challenges of the clinical application for minimally invasive implantation of TEHV are also discussed.

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Potential applications of three-dimensional structure of silk fibroin/poly(ester-urethane) urea nanofibrous scaffold in heart valve tissue engineering

Cited by 47 publications

References 46 publications

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

Protein-Based Fiber Materials in Medicine: A Review

Biodegradable synthetic polymeric composite scaffold‐based tissue engineered heart valve with minimally invasive transcatheter implantation

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