volume 55, issue 4, P1067-1076 1990
DOI: 10.1135/cccc19901067
View full text
|
|
Share

Abstract: Reaction of 2-(ethoxycarbonylamino)ethanol with 2-propylpentanoyl chloride gave the ester III. N-(4-Piperidinyl)-2-propylpentanamide (V) was prepared via the 1-benzyl-4-piperidinyl derivative IV and was acylated with ethanesulfonyl chloride and 2-propylpentanoyl chloride to give the amides VI and VII. Malonic ester syntheses afforded diethyl 2-ethyl- and 2-propyl-2-(2-(methylthio)ethyl)malonate VIII and XIII which were hydrolyzed and decarboxylated to the acids X and XV which, in turn, were transformed to the …

expand abstract