Potential Alzheimer's disease therapeutic nano-platform: Discovery of amyloid-beta plaque disaggregating agent and brain-targeted delivery system using porous silicon nanoparticles

In Situ Activatable Nitrobenzene–Cysteine–Copper(II) Nano-complexes for Programmed Photodynamic Cancer Therapy

“…This could be attributed to the over-enhanced ROS levels. It has been reported that ROS generation by PDT could stimulate the immune system. − In comparison to the PBS-treated group, the CyP -treated group exhibited increased levels of Endostatin/collagen XVIII, MMP-3, Coagulation Factor III, IL-1a, PEDF, IL-1b, and CD26 proteins, indicating a potential promotion of angiogenesis. However, upon irradiation with light, the protein levels of these angiogenic factors decreased.…”

“…Our research group has primarily focused on developing bioactive materials based on organic–inorganic hybrids to enhance their biocompatibility, disease targeting, and therapeutic efficiency. − Recently, we have focused on nitrobenzene derivatives that can be activated by stimuli such as biomolecules and photoirradiation, − and we designed a way to utilize biomolecule-/photo-reactive nitrobenzene-based metal-coordinated nano-complexes for cancer therapy in this work. Among the metal ions, copper­(II) is particularly noteworthy due to its anti-cancer effect, achieved by depleting GSH .…”

Mannose-Integrated Nanoparticle Hitchhike Glucose Transporter 1 Recycling to Overcome Various Barriers of Oral Delivery for Alzheimer’s Disease Therapy

“…17−19 Previous studies have harnessed the hydrophilic and negatively charged properties of PEG to facilitate PEGylated nanoparticles crossing the mucus barrier and prolong systemic long circulation. 20,21 However, these characteristics are in conflict with the requirement for lipophilicity and positive electronegativity necessary to traverse the cellular barrier, and coupled with the lack of active targeting, there is still ample opportunity for enhancing the capacity of PEGylated nanoparticles to traverse the barrier. Meanwhile, the predominant focus of current nanodelivery system designs lies in targeting a singular barrier type when traversing cellular barriers.…”

“…The scarcity of studies in oral brain-targeting drug delivery can mainly be ascribed to the multitude of biochemical and physiological obstacles encountered by drugs upon oral administration, encompassing both the intestinal epithelial barrier (IEB) and the blood-brain barrier (BBB). , The five steps are briefly outlined as “BMIBB”: (1) Crossing of the b iochemical barrier: Nanoparticles must maintain stability in the presence of abundant enzymes and withstand extreme pH fluctuations. , (2) Crossing the m ucus barrier: Nanoparticles must rapidly navigate a continuously replenished hydrogel network with robust viscoelastic properties. , (3) Crossing the I EB: Nanoparticles need to effectively penetrate the physical transport barrier located between the intestinal tract and bloodstream . (4) Crossing the b lood barrier: Nanoparticles must evade protein adsorption and phagocytosis by the mononuclear phagocyte system (MPS) in the bloodstream. , (5) Crossing the B BB: Nanoparticles must first undergo BBB recognition and subsequently overcome this formidable obstacle. − Previous studies have harnessed the hydrophilic and negatively charged properties of PEG to facilitate PEGylated nanoparticles crossing the mucus barrier and prolong systemic long circulation. , However, these characteristics are in conflict with the requirement for lipophilicity and positive electronegativity necessary to traverse the cellular barrier, and coupled with the lack of active targeting, there is still ample opportunity for enhancing the capacity of PEGylated nanoparticles to traverse the barrier. Meanwhile, the predominant focus of current nanodelivery system designs lies in targeting a singular barrier type when traversing cellular barriers .…”

Controllable Fabrication of Silicon Nanopore Arrays by Two-Step Inductively Coupled Plasma Etching Using Self-Assembled Anodic Aluminum Oxide Mask

“…Micro-nano porous silicon materials have been widely studied and applied owing to their excellent properties compared with those of bulk materials. [1][2][3][4][5][6][7][8][9] For instance, in terms of crystal growth, gallium nitride epitaxy on silicon substrates with porous arrays can significantly reduce its threading dislocation density and enhance its output power. 6 Considering biosensors, porous silicon particles are used in drug-delivery systems based on their biodegradation characteristics.…”