Potent Therapeutic Effect of Carbamazepine-10,11-Epoxide in Trigeminal Neuralgia

Evaluation of a novel mouse model of intracisternal strychnine-induced trigeminal allodynia

“…5 These findings are consistent with clinical findings which show that carbamazepine is an effective first-line treatment 9 and that morphine is ineffective. The best justification for an animal model of human disease is a demonstration of the ability of the model to predict which drugs could be effective in humans.…”

“…9 Systemic administration of carbamazepine is widely documented and would be expected to achieve similar brainstem therapeutic target levels; however, systemic administration could complicate behavioural observations as there are several active metabolites of carbamazepine with differing potencies and side effects. While the efficacy of CBZe is higher in our model than that of carbamazepine in human trigeminal neuralgia, the ability to manifest and localize the effect was considered to be of greater importance than establishing analogous dosing potencies.…”

Evaluation of a novel mouse model of intracisternal strychnine-induced trigeminal allodynia

“…5 These findings are consistent with clinical findings which show that carbamazepine is an effective first-line treatment 9 and that morphine is ineffective. The best justification for an animal model of human disease is a demonstration of the ability of the model to predict which drugs could be effective in humans.…”

“…9 Systemic administration of carbamazepine is widely documented and would be expected to achieve similar brainstem therapeutic target levels; however, systemic administration could complicate behavioural observations as there are several active metabolites of carbamazepine with differing potencies and side effects. While the efficacy of CBZe is higher in our model than that of carbamazepine in human trigeminal neuralgia, the ability to manifest and localize the effect was considered to be of greater importance than establishing analogous dosing potencies.…”

Free and Total Serum Concentrations of Carbamazepine and Carbamazepine‐10, 11‐Epoxide in Infancy and Childhood

“…Finally, the results reported here might be of practical importance if CBZ-E contributes to the pharmacological effect of CBZ in epilepsy, as it does in trigeminal neuralgia (Tomson and Bertilsson, 1984). In this case, the simultaneous monitoring of CBZ and CBZ-E could provide a better indication of pharmacological activity, especially among younger children.…”

Transformation of the Recalcitrant Pharmaceutical Compound Carbamazepine by Pleurotus ostreatus : Role of Cytochrome P450 Monooxygenase and Manganese Peroxidase

“…Under these conditions, P. ostreatus exhibited the highest removal ability of this recalcitrant compound as compared to other tested fungi 10À13 and was transformed to 10,11EPCBZ, which was stable and accumulated in the media. It is important to note that 10,11EPCBZ has pharmacological activity similar to that of its parent compound, 29 and was also detected in wastewater effluents. 30 To evaluate the potential use of P. ostreatus to remediate contaminated water, we studied CBZ removal from its environmental relevance concentration (∼1 μg L À1 , 4.6 nM) (ref 5 and references therein).…”

“…Under these conditions, P. ostreatus exhibited the highest removal ability of this recalcitrant compound as compared to other tested fungi − and was transformed to 10,11EPCBZ, which was stable and accumulated in the media. It is important to note that 10,11EPCBZ has pharmacological activity similar to that of its parent compound, and was also detected in wastewater effluents …”

Evaluation of a novel mouse model of intracisternal strychnine-induced trigeminal allodynia

“…5 These findings are consistent with clinical findings which show that carbamazepine is an effective first-line treatment 9 and that morphine is ineffective. The best justification for an animal model of human disease is a demonstration of the ability of the model to predict which drugs could be effective in humans.…”

“…9 Systemic administration of carbamazepine is widely documented and would be expected to achieve similar brainstem therapeutic target levels; however, systemic administration could complicate behavioural observations as there are several active metabolites of carbamazepine with differing potencies and side effects. While the efficacy of CBZe is higher in our model than that of carbamazepine in human trigeminal neuralgia, the ability to manifest and localize the effect was considered to be of greater importance than establishing analogous dosing potencies.…”

Free and Total Serum Concentrations of Carbamazepine and Carbamazepine‐10, 11‐Epoxide in Infancy and Childhood

“…Finally, the results reported here might be of practical importance if CBZ-E contributes to the pharmacological effect of CBZ in epilepsy, as it does in trigeminal neuralgia (Tomson and Bertilsson, 1984). In this case, the simultaneous monitoring of CBZ and CBZ-E could provide a better indication of pharmacological activity, especially among younger children.…”

Transformation of the Recalcitrant Pharmaceutical Compound Carbamazepine by Pleurotus ostreatus : Role of Cytochrome P450 Monooxygenase and Manganese Peroxidase

“…Under these conditions, P. ostreatus exhibited the highest removal ability of this recalcitrant compound as compared to other tested fungi 10À13 and was transformed to 10,11EPCBZ, which was stable and accumulated in the media. It is important to note that 10,11EPCBZ has pharmacological activity similar to that of its parent compound, 29 and was also detected in wastewater effluents. 30 To evaluate the potential use of P. ostreatus to remediate contaminated water, we studied CBZ removal from its environmental relevance concentration (∼1 μg L À1 , 4.6 nM) (ref 5 and references therein).…”

“…Under these conditions, P. ostreatus exhibited the highest removal ability of this recalcitrant compound as compared to other tested fungi − and was transformed to 10,11EPCBZ, which was stable and accumulated in the media. It is important to note that 10,11EPCBZ has pharmacological activity similar to that of its parent compound, and was also detected in wastewater effluents …”

Evaluation of a novel mouse model of intracisternal strychnine-induced trigeminal allodynia

“…5 These findings are consistent with clinical findings which show that carbamazepine is an effective first-line treatment 9 and that morphine is ineffective. The best justification for an animal model of human disease is a demonstration of the ability of the model to predict which drugs could be effective in humans.…”

“…9 Systemic administration of carbamazepine is widely documented and would be expected to achieve similar brainstem therapeutic target levels; however, systemic administration could complicate behavioural observations as there are several active metabolites of carbamazepine with differing potencies and side effects. While the efficacy of CBZe is higher in our model than that of carbamazepine in human trigeminal neuralgia, the ability to manifest and localize the effect was considered to be of greater importance than establishing analogous dosing potencies.…”

Free and Total Serum Concentrations of Carbamazepine and Carbamazepine‐10, 11‐Epoxide in Infancy and Childhood

“…Finally, the results reported here might be of practical importance if CBZ-E contributes to the pharmacological effect of CBZ in epilepsy, as it does in trigeminal neuralgia (Tomson and Bertilsson, 1984). In this case, the simultaneous monitoring of CBZ and CBZ-E could provide a better indication of pharmacological activity, especially among younger children.…”

Transformation of the Recalcitrant Pharmaceutical Compound Carbamazepine by Pleurotus ostreatus : Role of Cytochrome P450 Monooxygenase and Manganese Peroxidase

“…Under these conditions, P. ostreatus exhibited the highest removal ability of this recalcitrant compound as compared to other tested fungi 10À13 and was transformed to 10,11EPCBZ, which was stable and accumulated in the media. It is important to note that 10,11EPCBZ has pharmacological activity similar to that of its parent compound, 29 and was also detected in wastewater effluents. 30 To evaluate the potential use of P. ostreatus to remediate contaminated water, we studied CBZ removal from its environmental relevance concentration (∼1 μg L À1 , 4.6 nM) (ref 5 and references therein).…”

“…Under these conditions, P. ostreatus exhibited the highest removal ability of this recalcitrant compound as compared to other tested fungi − and was transformed to 10,11EPCBZ, which was stable and accumulated in the media. It is important to note that 10,11EPCBZ has pharmacological activity similar to that of its parent compound, and was also detected in wastewater effluents …”