Potent adjuvant effect elicited for tumor immunotherapy by a liposome conjugated pH-sensitive polymer and dendritic cell-targeting Toll-like-receptor ligand

Watanabe, Shun‐ichi; Yuba, Eiji; Akazawa, Takashi; Wijewardana, Viskam; Kakihara, Yuka; Azuma, Ayaka; Hagimori, Kenji; Kanegi, Ryoji; Hatoya, Shingo; Inoue, Norimitsu; Inaba, Toshio; Sugiura, Kikuya

doi:10.1016/j.vaccine.2022.01.048

Cited by 8 publications

(1 citation statement)

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“…Modification of liposomes with a pH-sensitive polymer (ChexPG-PE) and a TLR2 ligand (h11c) can serve as a tool for neoantigen vaccine transport. The modified liposomal vaccine (h11c-Chex) enhanced the target activation of DCs and inhibited tumor growth [126]. The design of liposomal nanoparticle platforms responsive to the acidic tumor microenvironment enables controlled delivery and release of neoantigens.…”

Section: Lipid Nanoparticles (Lnps)mentioning

confidence: 99%

Nanomaterial Delivery Vehicles for the Development of Neoantigen Tumor Vaccines for Personalized Treatment

Huang,

Zhu,

Yang

et al. 2024

Molecules

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Tumor vaccines have been considered a promising therapeutic approach for treating cancer in recent years. With the development of sequencing technologies, tumor vaccines based on neoantigens or genomes specifically expressed in tumor cells, mainly in the form of peptides, nucleic acids, and dendritic cells, are beginning to receive widespread attention. Therefore, in this review, we have introduced different forms of neoantigen vaccines and discussed the development of these vaccines in treating cancer. Furthermore, neoantigen vaccines are influenced by factors such as antigen stability, weak immunogenicity, and biosafety in addition to sequencing technology. Hence, the biological nanomaterials, polymeric nanomaterials, inorganic nanomaterials, etc., used as vaccine carriers are principally summarized here, which may contribute to the design of neoantigen vaccines for improved stability and better efficacy.

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Section: Lipid Nanoparticles (Lnps)mentioning

confidence: 99%