Postural tachycardia syndrome (POTS) and antiphospholipid syndrome (APS): What do we know so far?

Noureldine, Hussein A; Hasbani, Georges El; Eldine, Mariam Nour; Nour‐Eldine, Wared; Taher, Alì; Uthman, Imad

doi:10.1016/j.neurol.2021.10.006

Cited by 4 publications

(2 citation statements)

References 111 publications

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“… 88 Moreover, one published study documented the in-hospital discharge trends for patients with acute heart failure and highlighted the need for enlisting complete education as part of the discharge process, in addition to abidance to the guidelines in prescribing medication 89 while another study summarized common etiologies for post-orthostatic tachycardia syndrome such as infections, especially viral, pregnancy, and stress. 90 …”

Section: Resultsmentioning

confidence: 99%

Identifying health research in the era of COVID-19: A scoping review

Samah

2023

SAGE Open Medicine

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Background: Health improvements are considered one of the most important fields of research. Since the coronavirus disease 2019 was declared a pandemic, it might have impacted clinical and public health research in various forms. Objectives: The goal of this study is to explore health research approaches in the era of coronavirus disease 2019. Methods: In this scoping review, we reviewed published medical full-text studies and identified potential areas of interest of health research in the era the coronavirus disease 2019 pandemic during the last 3 years within a higher educational setting. A bibliometric analysis was used to compare among published works. Results: Among the 93 studies that met the inclusion criteria, most focused on mental health ( n = 23; 24.7%). Twenty-one publications targeted coronavirus disease 2019 and its consequences on general health. Other studies have described hemato-oncological, cardiovascular, respiratory, and endocrinological diseases. 42 studies were cross-sectional or cohort studies and most of them published in Q1 journals. Almost half of them belonged to the Faculty of Medicine (49.5%) followed by the School of Arts, Sciences, and Psychology (26.9%). Conclusions: Health research has been demonstrated to be important, at all times, especially during crises. Therefore, researchers need to invest more efforts into seeking new medical updates in various health-related fields, regardless of their correlation with coronavirus disease 2019.

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Section: Resultsmentioning

confidence: 99%

Identifying health research in the era of COVID-19: A scoping review

Samah

2023

SAGE Open Medicine

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“…In addition to dysautonomia, APS is associated with a host of cardiac and neurologic manifestations. Both POTS and APS involve inflammatory cytokines (191) and can be triggered by viral infections, stress, and pregnancy. In Long COVID patients, autonomic dysfunction and some neurologic symptoms could be due to "sticky blood" and microclots resistant to fibrinolysis.…”

Section: Orthostatic Tachycardia-autonomic Nervous System Dysfunctionmentioning

confidence: 99%

A review of cytokine-based pathophysiology of Long COVID symptoms

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Akrami

2023

Front. Med.

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The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is prolonged, or new symptoms are developed over months. Here, we propose a description of the pathophysiology of the Long COVID presentation based on inflammatory cytokine cascades and the p38 MAP kinase signaling pathways that regulate cytokine production. In this model, the SARS-CoV-2 viral infection is hypothesized to trigger a dysregulated peripheral immune system activation with subsequent cytokine release. Chronic low-grade inflammation leads to dysregulated brain microglia with an exaggerated release of central cytokines, producing neuroinflammation. Immunothrombosis linked to chronic inflammation with microclot formation leads to decreased tissue perfusion and ischemia. Intermittent fatigue, Post Exertional Malaise (PEM), CNS symptoms with “brain fog,” arthralgias, paresthesias, dysautonomia, and GI and ophthalmic problems can consequently arise as result of the elevated peripheral and central cytokines. There are abundant similarities between symptoms in Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). DNA polymorphisms and viral-induced epigenetic changes to cytokine gene expression may lead to chronic inflammation in Long COVID patients, predisposing some to develop autoimmunity, which may be the gateway to ME/CFS.

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