Posttraumatic stress disorder in vietnam veterans clinical and EEG findings; possible therapeutic effects of carbamazepine

Wolf, Marion E.; Alavi, Afshin; Mosnaim, Aron D.

doi:10.1016/0006-3223(88)90011-x

Cited by 89 publications

(31 citation statements)

References 4 publications

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“…The oscillations were lumped into different frequency bands, and each band was characterized by the type of behavior that coincided with the brain rhythms in that band (Pfurtscheller and Aranibar 1977). Eventually looking at the power in each band became common practice for classifying segments of steady-state brain activity such as depth of anesthesia, sleep stages, and stress levels (Lewis et al 2012;Weiss et al 2011;Wolf et al 1988).…”

mentioning

confidence: 99%

Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

Sanders

2016

Journal of Neurophysiology

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Sanders TH. Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses. J Neurophysiol 115: 1587-1595, 2016. First published January 20, 2016 doi:10.1152/jn.00801.2015-Interactions between neural oscillations in the brain have been observed in many structures including the hippocampus, amygdala, motor cortex, and basal ganglia. In this study, one popular approach for quantifying oscillation interactions was considered: phase-amplitude coupling. The goals of the study were to use simulations to examine potential causes of elevated phase-amplitude coupling in parkinsonism, to compare simulated parkinsonian signals with recorded local field potentials from animal models of parkinsonism, to investigate possible relationships between increased bursting in parkinsonian single cells and elevated phase-amplitude coupling, and to uncover potential noise and artifact effects. First, a cell model that integrates incremental input currents and fires at realistic voltage thresholds was modified to allow control of stochastic parameters related to firing and burst rates. Next, the input currents and distribution of integration times were set to reproduce firing patterns consistent with those from parkinsonian subthalamic nucleus cells. Then, local field potentials were synthesized from the output of multiple simulated cells with varying degrees of synchronization and compared with subthalamic nucleus recordings from animal models of parkinsonism. The results showed that phase-amplitude coupling can provide important information about underlying neural activity. In particular, signals synthesized from synchronized bursting neurons showed increased oscillatory interactions similar to those observed in parkinsonian animals. Additionally, changes in bursting parameters such as the intraburst rate, the mean interburst period, and the amount of synchronization between neurons influenced the phase-amplitude coupling in predictable ways. Finally, simulation results revealed that small periodic signals can have a surprisingly large masking effect on phase-amplitude coupling.

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confidence: 99%

Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

Sanders

2016

Journal of Neurophysiology

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“…8,44 Some ED patients may also have a history of posttraumatic stress disorder (PTSD) or head injuries, both of which have been linked to violent behavior. 45,46 In addition to targeting and treating depression and alcohol use, other cognitive and neurologic states and conditions could be targeted for clinical intervention. For example, treatment with antiepileptics has been used effectively to reduce impulsivity and to prevent violent behavior in males with PTSD and temper outbursts [46][47][48] or organic brain syndromes.…”

Section: Discussionmentioning

confidence: 99%

“…45,46 In addition to targeting and treating depression and alcohol use, other cognitive and neurologic states and conditions could be targeted for clinical intervention. For example, treatment with antiepileptics has been used effectively to reduce impulsivity and to prevent violent behavior in males with PTSD and temper outbursts [46][47][48] or organic brain syndromes. [49][50][51] We recognize that behavior patterns such as alcoholic and aggressive tendencies can lead to cognitive states, for example, depression.…”

Section: Discussionmentioning

confidence: 99%

The Relationship among Depressive and Alcoholic Symptoms and Aggressive Behavior in Adult Male Emergency Department Patients

Bacaner

Kinney

Biros

et al. 2002

Academic Emergency Medicine

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“…Wolf, Alavi, and Mosnaim (1988) examined the EEG activity in sleep and waking states of PTSD patients to find that all EEG parameters (in sleep and awake) were within normal limits. Begic, Hotujac, and Jokic-Begic (2001) using conventional spectral methods found that PTSD patients had increased theta activity over central regions and increased beta activity over frontal, central and left occipital regions.…”

Section: Eeg In Ptsdmentioning

confidence: 99%

Integrating Cognitive Neuroscience Research and Cognitive Behavioral Treatment with Neurofeedback Therapy in Drug Addiction Comorbid with Posttraumatic Stress Disorder: A Conceptual Review

Sokhadze¹,

Stewart²,

Hollifield³

2007

Journal of Neurotherapy

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Posttraumatic stress disorder in vietnam veterans clinical and EEG findings; possible therapeutic effects of carbamazepine

Cited by 89 publications

References 4 publications

Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

The Relationship among Depressive and Alcoholic Symptoms and Aggressive Behavior in Adult Male Emergency Department Patients

Integrating Cognitive Neuroscience Research and Cognitive Behavioral Treatment with Neurofeedback Therapy in Drug Addiction Comorbid with Posttraumatic Stress Disorder: A Conceptual Review

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