Posttransplant diabetes mellitus in renal transplant patients with hepatitis C virus

Sens, Yvoty Alves dos Santos; Silva, V.D.S.T; Malafronte, Patrícia; Souza, José Ferraz de; Miorin, Luiz Antonio; Jabur, Pedro

doi:10.1016/j.transproceed.2004.03.092

Cited by 15 publications

(15 citation statements)

References 12 publications

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“…Most Cϩ patients died as a result of cardiovascular disease, the leading cause of death in renal transplant recipients. The incidence of diabetes is increased in Cϩ patients (18), and this may have contributed to increased cardiovascular morbidity, but we could not examine this. Overall, a long-term survival free from liver failure was seen in approximately 50% of our virally infected patients.…”

Section: Resultsmentioning

confidence: 99%

Natural History of Hepatitis B and C in Renal Allograft Recipients

et al. 2005

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Section: Resultsmentioning

confidence: 99%

Natural History of Hepatitis B and C in Renal Allograft Recipients

et al. 2005

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“…In this study, a significant interaction (P = 0.0001) was found between presence of HCV and use of tacrolimus, since in the HCV-positive group, T2D occurred more often in tacrolimus-treated than cyclosporine A-treated patients (57.8% vs 7.7%; P < 0.0001) [55] . Most subsequent studies confir med this robust association [56][57][58][59][60][61][62][63] , with some exceptions [21,[64][65][66] . Thus, in a recent meta-analysis of 10 studies, the pooled relative risk for post-KT T2D was 2.73 (95% CI: 1.94-3.83) [67] .…”

Section: Association Between Hcv and T2dmentioning

confidence: 95%

Hepatitis C virus and type 2 diabetes

Negro¹,

Alaei²

2009

WJG

143

118

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This review focuses on the relationship between h e p a t i t i s C v i r u s ( H C V ) i n fe c t i o n a n d g l u c o s e metabolism derangements. Cross-sectional and longitudinal studies have shown that the chronic HCV infection is associated with an increased risk of developing insulin resistance (IR) and type 2 diabetes (T2D). The direct effect of HCV on the insulin signaling has been analyzed in experimental models. Although currently available data should be considered as preliminary, HCV seems to affect glucose metabolism via mechanisms that involve cellular pathways that have been implicated in the host innate immune response. IR and T2D not only accelerate the histological and clinical progression of chronic hepatitis C, but also reduce the early and sustained virological response to interferonalpha-based therapy. Thus, a detailed knowledge of the mechanisms underlying the HCV-associated glucose metabolism derangements is warranted, in order to improve the clinical management of chronic hepatitis C patients.

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“…23 The relatively high incidence of PTDM in HCV-positive patients may be explained by a direct or immune-mediated effect on the B cells of pancreatic islets. 24 However, no association was found between HCV infection and the development of PTDM in a cohort of 25 HCV- 25 . These differing fi ndings may be attributed to different immunosuppressant protocols and different patient groups.…”

Section: Discussionmentioning

confidence: 97%

Hepatic dysfunction in kidney transplant recipients: prevalence and impact on graft and patient survival

et al. 2007

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Viral infections-especially HCV and CMV-were more prevalent in the group of patients with persistent hepatic dysfunction, with duration of dialysis as an important risk factor for HCV infection. Dose-dependent cyclosporine-induced hepatic dysfunction was observed early post-transplant. Neither tacrolimus- nor sirolimus-associated hepatic dysfunction was dose-dependent. Hepatic dysfunction had no significant impact on either patient or graft survival; however, this finding may be due to the relatively short duration of follow up.

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Posttransplant diabetes mellitus in renal transplant patients with hepatitis C virus

Cited by 15 publications

References 12 publications

Natural History of Hepatitis B and C in Renal Allograft Recipients

Natural History of Hepatitis B and C in Renal Allograft Recipients

Hepatitis C virus and type 2 diabetes

Hepatic dysfunction in kidney transplant recipients: prevalence and impact on graft and patient survival

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