1986
DOI: 10.1001/archderm.122.4.464
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Postproctoscopic periorbital purpura. Primary systemic amyloidosis

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Cited by 11 publications
(6 citation statements)
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“…5 Deposition of amyloid within cutaneous blood vessel walls result in vascular fragility, and minor trauma may precipitate these lesions, referred to by some as "pinch purpura". 6 Cutaneous lesions can also present as waxy papules, morphealike plaques, alopecia, nail dystrophies, macroglossia and pigmentary alteration. 7 In this case, our patient had no other systemic complaints, and periorbital purpura was the only diagnostic clue for underlying multiple myeloma.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…5 Deposition of amyloid within cutaneous blood vessel walls result in vascular fragility, and minor trauma may precipitate these lesions, referred to by some as "pinch purpura". 6 Cutaneous lesions can also present as waxy papules, morphealike plaques, alopecia, nail dystrophies, macroglossia and pigmentary alteration. 7 In this case, our patient had no other systemic complaints, and periorbital purpura was the only diagnostic clue for underlying multiple myeloma.…”
mentioning
confidence: 99%
“…Among cutaneous lesions, petechiae and ecchymoses, especially in the periorbital and facial area, are most common 5 . Deposition of amyloid within cutaneous blood vessel walls result in vascular fragility, and minor trauma may precipitate these lesions, referred to by some as “pinch purpura” 6 . Cutaneous lesions can also present as waxy papules, morphea‐like plaques, alopecia, nail dystrophies, macroglossia and pigmentary alteration 7 .…”
mentioning
confidence: 99%
“…Bleeding events can be exacerbated by acquired coagulopathy due to plasma cell dyscrasia−associated thrombocytopenia, amyloid fibril adsorption of factor X, or hypofibrinogenemia 11,12 . Periorbital purpura following minor trauma or transient venous hypertension is characteristic of AL amyloidosis 6,13 . In this case, positive pressure ventilation and recumbent positioning increased hydrostatic pressure in the head and neck, causing rupture of the infiltrated small vessels around the eyes and in the oral cavity 14 …”
Section: Discussionmentioning
confidence: 99%
“…As this condition is usually associated with B-cell or Plasma cell proliferation so plasma cell dyscrasia must be excluded. [9,11,[12][13][14][15][16]…”
Section: Eyelid Involvementmentioning
confidence: 99%
“…Gelatinous drop-like corneal dystrophy (GDCD),( also known as : Lattice corneal dystrophy type III, Familial subepithelial corneal amyloidosis, primary familial amyloidosis of the cornea) is a rare corneal dystrophy,first described by Nakaizumi in 1914 and mainly affects Asian descent but can occurs in diverse ethnic groups throughout the US, Europe and the Asia. 14,15 Inheritance pattern of this dystrophy is Autosomal Dominant and its gene ( TACSTD2 gene ) located on 1p32. Although More than 25 mutations in TACSTD2 gene encoding Tumor-associated calcium signal transducer 2 have been described,some patients with this corneal dystrophy doesn't have this mutation suggesting genetic heterogenicity and probability involvement of other genes in this autosomal recessive disease.…”
Section: Gelatinous Drop-like Corneal Dystrophymentioning
confidence: 99%