Postprandial prolactin suppression appears absent in antipsychotic-treated male patients

Coello, Klara; Broberg, Brian Villumsen; Bak, Nikolaj; Madsen, Anders; Mortensen, Henrik B.; Søgaard, Birgitte; Szecsi, Pal B.; Knop, Filip K.; Lublin, Henrik; Ebdrup, Bjørn H

doi:10.1016/j.psyneuen.2015.05.014

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Moreover, we intentionally included a naturalistic trial population (18), which is reflected in the broad medication profiles (Supplementary Table 1). To this end, individual antipsychotic compounds may affect prolactin levels (22, 31, 32), and bone status differentially, but the current data did not allow for separating effects of specific antipsychotics. Finally, patients were not instructed to keep their level of physical activity stable and refrain from taking vitamin D supplements during the trial, and we were therefore unable to control for these potential confounders.…”

Section: Discussionmentioning

confidence: 87%

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Bone Status in Obese, Non-diabetic, Antipsychotic-Treated Patients, and Effects of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide on Bone Turnover Markers and Bone Mineral Density

et al. 2019

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Background: Low bone mineral density (BMD) may constitute an underestimated comorbidity in schizophrenia patients undergoing long-term antipsychotic treatment. Glucagon-like peptide 1 (GLP-1) receptor agonists are antidiabetic drugs, which may also affect bone turnover.Methods: In planned secondary analyses of a 3 months, double-blind, randomized, placebo-controlled trial (n = 45), we explored effects of the GLP-1 receptor agonist exenatide 2 mg once-weekly (n = 23), or placebo (n = 22) on bone turnover markers (BTMs) and BMD in chronic, obese, antipsychotic-treated patients with schizophrenia spectrum disorder. Baseline BTMs were compared to sex- and age-adjusted reference values from a Danish population cohort, and T- and Z-scores were calculated for BMD.Results: In women (n = 24), all baseline BTM measurements of procollagen type I N-terminal propeptide (PINP) and C-terminal cross-linking telopeptide of type I collagen (CTX) were within reference values. In men (n = 21), 5% displayed lower PINP and 14% displayed lower CTX. One patient displayed BMD Z-score < −2, and 23% of patients (17% of women and 29% of men) displayed −2.5 < T-scores < –1 indicating osteopenia, but none had osteoporosis. After treatment, PINP decreased at trend level significance (P = 0.05), and body mass index BMD increased for L2–L4 (P = 0.016). No changes in bone markers were significant after correction for mean prolactin levels.Conclusions: Sex- and age-adjusted measures of bone status in chronic, obese, antipsychotic-treated patients appeared comparable to the reference population. Subtle changes in bone markers during 3 months exenatide treatment may suggest beneficial effects of GLP-1 receptor agonists on bone status in antipsychotic-treated patients, and further studies should consider the potential influence of prolactin.

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Section: Discussionmentioning

confidence: 87%

“…All biochemical analyses were performed at the Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark. Since CTX (8) and prolactin (22) are influenced by diurnal variations, all blood samples were collected in the morning before food intake (fasting >8 h).…”

Section: Methodsmentioning

confidence: 99%

Bone Status in Obese, Non-diabetic, Antipsychotic-Treated Patients, and Effects of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide on Bone Turnover Markers and Bone Mineral Density

et al. 2019

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“…D2R antagonism is associated with extrapyramidal side-effects, hyperprolactinemia (Coello et al, 2015), dyslipidemia (Ebdrup et al, 2014), weight gain (Nielsen et al, 2016), as well as subcortical structural brain changes (Ebdrup et al, 2013). Moreover, D2R antagonism may induce tardive dyskinesia and secondary cognitive impairments, and the extrapyramidal side-effects reduce compliance all of which increase the risk of relapse (Meltzer, 2013).…”

Section: Introductionmentioning

confidence: 99%

Identification of a Serotonin 2A Receptor Subtype of Schizophrenia Spectrum Disorders With Pimavanserin: The Sub-Sero Proof-of-Concept Trial Protocol

et al. 2020

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Background: All current approved antipsychotic drugs against schizophrenia spectrum disorders share affinity for the dopamine receptor (D2R). However, up to one-third of these patients respond insufficiently, and in some cases, side-effects outweigh symptom reduction. Previous data have suggested that a subgroup of antipsychotic-naïve patients will respond to serotonin 2A receptor (2AR) blockade. Aims: This investigator-initiated, translational, proof-of-concept study has overall two aims; 1) To test the clinical effectiveness of monotherapy with the newly approved drug against Parkinson's disease psychosis, pimavanserin, in antipsychotic-free patients with first-episode schizophrenia spectrum disorders; 2) To characterize the neurobiological profile of responders to pimavaserin. Materials and Equipment: Forty patients will be enrolled in this 6-week open label, onearmed trial with the selective serotonin 2AR antagonist (pimavanserin 34 mg/day). At baseline, patients will undergo: positron emission tomography (PET) imaging of the serotonin 2AR using the radioligand [¹¹C]Cimbi-36; structural magnetic resonance imaging (MRI); MR spectroscopy of cerebral glutamate levels and diffusion tensor imaging; cognitive and psychopathological examinations; electrocardiogram, and blood sampling for genetic-and metabolic analyses. Outcome Measures: The primary clinical endpoint will be reduction in the Positive and Negative Syndrome Scale (PANSS) positive score. Secondary clinical endpoints comprise multiple clinical ratings (positive and negative symptoms, depressive-, obsessivecompulsive symptoms, quality of life, social functioning, sexual functioning, and side

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Prevention and Treatment of Obesity and Metabolic Dysfunction in Children with Major Behavioral Disorders: Second-Generation Antipsychotics

Reeves

Sikich

2017

Contemporary Endocrinology

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Postprandial prolactin suppression appears absent in antipsychotic-treated male patients

Cited by 7 publications

References 15 publications

Bone Status in Obese, Non-diabetic, Antipsychotic-Treated Patients, and Effects of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide on Bone Turnover Markers and Bone Mineral Density

Bone Status in Obese, Non-diabetic, Antipsychotic-Treated Patients, and Effects of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide on Bone Turnover Markers and Bone Mineral Density

Identification of a Serotonin 2A Receptor Subtype of Schizophrenia Spectrum Disorders With Pimavanserin: The Sub-Sero Proof-of-Concept Trial Protocol

Prevention and Treatment of Obesity and Metabolic Dysfunction in Children with Major Behavioral Disorders: Second-Generation Antipsychotics

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