2017
DOI: 10.5551/jat.rv16003
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Abstract: Fasting hypertriglyceridemia is positively associated with the morbidity of coronary heart disease (CHD), and postprandial (non-fasting) hypertriglyceridemia is also correlated with the risk status for CHD, which is related to the increase in chylomicron (CM) remnant lipoproteins produced from the intestine. CM remnant particles, as well as oxidized low density lipoprotein (LDL) or very low density lipoprotein (VLDL) remnants, are highly atherogenic and act by enhancing systemic inflammation, platelet activati… Show more

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Cited by 115 publications
(90 citation statements)
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References 132 publications
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“…6 With regard to TRLs, the patients presented very high peaks of postprandial TG and RemL-C levels at baseline, suggesting that they were at high ASCVD risk. 7,13,14 In this population, exposure to TRLs markedly decreased in both the fasting and nonfasting states, and the peaks of postprandial TG, apoB-48, and RemL-C levels shifted earlier after pemafibrate treatment than those at baseline or after placebo administration. The possible mechanisms of these effects include the suppression of intestinal absorption of cholesterol via the inhibition of Niemann-Pick c1-like 1 (NPC1L1) protein and chylomicron production, enhancement of TRL catabolism, and FGF21-mediated improvement of glycemic and lipid metabolism.…”
Section: Discussionmentioning
confidence: 84%
See 1 more Smart Citation
“…6 With regard to TRLs, the patients presented very high peaks of postprandial TG and RemL-C levels at baseline, suggesting that they were at high ASCVD risk. 7,13,14 In this population, exposure to TRLs markedly decreased in both the fasting and nonfasting states, and the peaks of postprandial TG, apoB-48, and RemL-C levels shifted earlier after pemafibrate treatment than those at baseline or after placebo administration. The possible mechanisms of these effects include the suppression of intestinal absorption of cholesterol via the inhibition of Niemann-Pick c1-like 1 (NPC1L1) protein and chylomicron production, enhancement of TRL catabolism, and FGF21-mediated improvement of glycemic and lipid metabolism.…”
Section: Discussionmentioning
confidence: 84%
“…12 Recently, the amelioration of exposure to accumulated TRLs has been highlighted as an important therapeutic target for ASCVD risk reduction. 7,13,14 Peroxisome proliferator-activated receptor a (PPARa) agonists are antidyslipidemic agents that decrease TG level and increase HDL cholesterol (HDL-C) level. They have been suggested to play a role in ASCVD risk reduction.…”
Section: Introductionmentioning
confidence: 99%
“…Both publications suggest that the cholesterol content of triglyceride‐rich lipoproteins poses a residual risk in patients receiving effective statin therapy. A correlation of RLP‐C and sdLDL has also been shown, and Kugiyama et al showed that patients in the highest RLP‐C tertile (>5.1 mg/dL) in a group of 135 CAD patients had a higher incidence of CAD events than those in the lowest tertile (≤3.3 mg/dL), even though their LDL‐C levels were <100 mg/dL In a later study of 190 patients treated with statins after ACS, they found that a high RLP‐C (≥5.4 mg/dL) was a significant risk of secondary events independent of conventional risk factors (HR 2.94, 95% CI 1.40–6.18; P < 0.01) . This study, which compared LDL‐C, sdLDL‐C, RLP‐C, non‐HDL‐C and ApoB in patients with stable CAD, found that only sdLDL‐C was independently associated with CE in patients treated with statins.…”
Section: Discussionmentioning
confidence: 88%
“…In particular, postprandial hypertriglyceridemia is strongly associated with an increased risk of cardiovascular disease. Small chylomicron remnants, generated from chylomicrons in the postprandial state, are recognized as a risk factor for coronary artery disease. In addition, postprandial hypertriglyceridemia has been shown to be independently associated with carotid IMT in patients with type 2 diabetes mellitus.…”
Section: Introductionmentioning
confidence: 99%